Chronic LPS exposure produces changes in intrinsic membrane properties and a sustained IL-β-dependent increase in GABAergic inhibition in hippocampal CA1 pyramidal neurons

Hippocampus ◽  
2005 ◽  
Vol 15 (5) ◽  
pp. 656-664 ◽  
Author(s):  
Ian C. Hellstrom ◽  
Marc Danik ◽  
Giamal N. Luheshi ◽  
Sylvain Williams
Keyword(s):  
Pyramidal Neurons ◽  
Membrane Properties ◽  
Gabaergic Inhibition ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Intrinsic Membrane Properties

scholarly journals Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy

1997 ◽  
Vol 94 (22) ◽  
pp. 12151-12156 ◽  
Author(s):  
M. Esclapez ◽  
J. C. Hirsch ◽  
R. Khazipov ◽  
Y. Ben-Ari ◽  
C. Bernard
Keyword(s):  
Pyramidal Neurons ◽  
Experimental Epilepsy ◽  
Gabaergic Inhibition ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1

Inhibitory processes of hippocampal CA1 pyramidal neurons following kindling-induced epilepsy in the rat

1985 ◽  
Vol 63 (7) ◽  
pp. 872-878 ◽  
Author(s):  
M. W. Oliver ◽  
J. J. Miller
Keyword(s):  
Pyramidal Neurons ◽  
Epileptiform Activity ◽  
Pyramidal Cells ◽  
Repetitive Stimulation ◽  
Membrane Properties ◽  
Stratum Radiatum ◽  
Inhibitory Processes ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Stimulation Of

To determine the alterations in cellular function which may contribute to the chronic predisposition of neuronal tissue to epileptiform activity, the membrane properties and inhibitory processes of hippocampal CA1 pyramidal cells were investigated using in vitro slices prepared from commissural-kindled rats. No changes were observed in resting membrane potential, input resistance, spike amplitude, and membrane time constant of "kindled" CA1 pyramidal neurons when compared with controls. There were also no differences between control and kindled preparations in the amplitude of recurrent inhibitory postsynaptic potentials (IPSP) and in the duration of inhibition produced by either alvear (Alv) or stratum radiatum (SR) stimulation. Irrespective of group, repetitive stimulation of the Alv reduced the amplitude of the recurrent IPSP but failed to induce seizurelike activity. On the other hand, repetitive stimulation of SR frequently produced a neuronal burst discharge even though the duration and to some extent the amplitude of orthodromic inhibition was increased. On the basis of these data, it may be suggested that chronic changes in CA1 pyramidal cell membrane properties and transient reductions of inhibitory processes do not underlie the enhanced sensitivity of these neurons to seizure activity associated with kindling.

scholarly journals 3P221 The endocrine disrupter Bisphenol-A acutely induces morphologica changes in rat hippocampal CA1 pyramidal neurons

2004 ◽  
Vol 44 (supplement) ◽  
pp. S245
Author(s):  
N Tanabe ◽  
Y Komatsuzaki ◽  
T Tsurugizawa ◽  
K Mitsuhashi ◽  
Y Ooishi ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Pyramidal Neurons ◽  
Endocrine Disrupter ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1
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