scholarly journals Angiotensin Converting Enzyme‐2 Therapy Improves Liver Fibrosis and Glycemic Control in Diabetic Mice With Fatty Liver

2021 ◽  
Author(s):  
Indu G. Rajapaksha ◽  
Lakmie S. Gunarathne ◽  
Khashayar Asadi ◽  
Ross Laybutt ◽  
Sof Andrikopoulous ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Liver Fibrosis ◽  
Angiotensin Converting Enzyme ◽  
Fatty Liver ◽  
Converting Enzyme ◽  
Diabetic Mice ◽  
Angiotensin Converting Enzyme 2

scholarly journals Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice

Hepatology ◽  
2009 ◽  
Vol 50 (3) ◽  
pp. 929-938 ◽  
Author(s):  
Christoph H. Österreicher ◽  
Kojiro Taura ◽  
Samuele De Minicis ◽  
Ekihiro Seki ◽  
Melitta Penz-Österreicher ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2

scholarly journals MO626EFFECTS OF RAMIPRIL IN LUNG AND KIDNEY ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) EXPRESSION IN A TYPE 2 DIABETIC MURINE MODEL: LESSONS FOR COVID-19 INFECTION

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ander Vergara Arana ◽  
Conxita Jacobs Cachá ◽  
Mireia Molina ◽  
Pamela Dominguez ◽  
Begoña Benito ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzymatic Activity ◽  
Mrna Expression ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Diabetic Mice ◽  
Angiotensin Converting Enzyme 2 ◽  
Ras Blockers ◽  
Activity Decrease

Abstract Background and Aims Angiotensin converting enzyme 2 (ACE2) is one of the components of the renin-angiotensin system (RAS) that mainly degrades angiotensin II to angiotensin-(1-7). ACE2 is predominantly expressed in the kidney and the heart, but it has been evidenced in type 2 alveolar lung cells, where it acts as a receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this context, a controversy arose as to whether the use of RAS blockers could increase ACE2 lung expression and the risk infection by COVID-19. This study aimed to investigate the effect of an ACE inhibitor (Ramipril) on ACE2 expression in experimental diabetes. Method 12 weeks old diabetic db/db mice (n=7) were given ramipril (8 mg/Kg/day) during 8 weeks or the respective vehicle. db/m (n=7) vehicle-treated non-diabetic mice were included as controls. ACE2 mRNA expression and enzymatic activity were studied in kidney, heart and lung samples of these animals to identify if the diabetic condition or treatment with ramipril modulated ACE2 expression. Results In vehicle-treated diabetic db/db animals, ACE2 mRNA expression was significantly increased in the kidney (p<0.001) and ramipril treatment reversed this effect (p=0.026). In the heart, ACE2 expression decreased in db/db when compared to db/m littermates (p=0.035) and ramipril had no effect. We found no differences in ACE2 gene expression in the lung. Besides, ACE2 enzymatic activity was increased in the kidney (29%) and also in the lung (16%) of db/db mice when compared to controls. Ramipril treatment decreased ACE2 activity a 19% in the lung and had no effect in the kidney when compared to untreated db/db (see figure). In the heart, ACE2 activity tended to decrease in db/db mice (29%) when compared to db/m and ramipril increased ACE2 activity (18%) but did not exceed the cardiac ACE2 activity of the db/m. Conclusion ACE2 is increased in the kidney and the lung, and decreased in the heart of diabetic mice. Ramipril treatment restores ACE2 levels. The results suggest that ACE inhibitors do not increase ACE2 expression and the activity decrease exerted in the lung may be protective against COVID-19 infection.

Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice

2015 ◽  
Vol 128 (10) ◽  
pp. 649-663 ◽  
Author(s):  
Yixuan Shi ◽  
Chao-Sheng Lo ◽  
Ranjit Padda ◽  
Shaaban Abdo ◽  
Isabelle Chenier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Converting Enzyme ◽  
Renal Injury ◽  
Receptor Expression ◽  
Systemic Hypertension ◽  
Converting Enzyme ◽  
Diabetic Mice ◽  
Angiotensin Converting Enzyme 2 ◽  
Mas Receptor

In summary, our data indicate an important role of Ang-(1–7) in inhibiting intrarenal oxidative stress and subsequent prevention of the development of hypertension and renal injury in diabetic mice.

Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice

2020 ◽  
Vol 100 (9) ◽  
pp. 1169-1183 ◽  
Author(s):  
Heleia Roca-Ho ◽  
Vanesa Palau ◽  
Javier Gimeno ◽  
Julio Pascual ◽  
María José Soler ◽  
...  
Keyword(s):  
Renal Function ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Diabetic Mice ◽  
Angiotensin Converting Enzyme 2
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