scholarly journals Liver Fibrosis Index FIB‐4 Is Associated With Mortality in COVID‐19

2020 ◽  
Author(s):  
Yijia Li ◽  
James Regan ◽  
Jesse Fajnzylber ◽  
Kendyll Coxen ◽  
Heather Corry ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Fibrosis Index

scholarly journals High liver fibrosis index FIB-4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers

Hepatology ◽  
2015 ◽  
Vol 61 (4) ◽  
pp. 1261-1268 ◽  
Author(s):  
Beomseok Suh ◽  
Sehhoon Park ◽  
Dong Wook Shin ◽  
Jae Moon Yun ◽  
Hyung-Kook Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Liver Fibrosis Index ◽  
High Liver

scholarly journals The Enhanced Liver Fibrosis Index Predicts Hepatic Fibrosis Superior to FIB4 and APRI in HIV/HCV Infected Patients

2020 ◽  
Author(s):  
Enass A Abdel-hameed ◽  
Susan D Rouster ◽  
Shyam Kottilil ◽  
Kenneth E Sherman
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Liver Histology ◽  
Superior Performance ◽  
Metavir Score ◽  
Noninvasive Biomarker ◽  
Advanced Liver Fibrosis ◽  
Noninvasive Biomarkers ◽  
Liver Fibrosis Index ◽  
Hcv Coinfection

Abstract Background Accurate noninvasive biomarkers of fibrotic progression are important for hepatitis C virus (HCV) management, but commonly used modalities may have decreased efficacy in human immunodeficiency virus (HIV)/HCV-coinfected persons. The enhanced liver fibrosis (ELF) index is a highly sensitive noninvasive marker of hepatic fibrosis that has had limited assessment in the HIV/HCV population. We compared ELF index performance to FIB4 and aspartate to platelet ratio index (APRI) at different stages of liver fibrosis as determined by liver histology, and validated the efficacy of the three noninvasive biomarkers in HIV/HCV-coinfected versus HCV-monoinfected. Methods The ELF index was determined in 147 HIV/HCV-coinfected and 98 HCV-monoinfected persons using commercial ELISA assays for the component elements of the index. Area under the receiver-operator curve was used to validate ELF and to compare its performance to liver histology as well as to other noninvasive biomarkers of liver fibrosis, FIB4, and APRI. Results The ELF index increased with histological stage of liver fibrosis and exhibited a linear relationship with Metavir score in all subjects. ELF performance was comparable between HIV/HCV and HCV with advanced liver fibrosis/cirrhosis. In the HIV/HCV cohort ELF cutoffs of 8.45 and 9.23 predicted mild and moderate fibrosis with 85% sensitivity, whereas the ELF cutoff of 9.8 had the highest specificity for advanced fibrosis and the cutoff of 10.4 was 99% specific for cirrhosis. ELF performance was superior to FIB4 and APRI in all subjects regardless of HIV status. Conclusions ELF index demonstrated excellent characteristics toward accurate prediction of liver fibrosis and cirrhosis with superior performance to APRI and FIB4 in HIV/HCV coinfection. Applying this noninvasive biomarker index for diagnosis of liver fibrosis and progression in HIV/HCV is warranted.

scholarly journals Validation and Refinement of Noninvasive Methods to Assess Hepatic Fibrosis: Magnetic Resonance Elastography Versus Enhanced Liver Fibrosis Index

2019 ◽  
Vol 65 (4) ◽  
pp. 1252-1257 ◽  
Author(s):  
Kenneth E. Sherman ◽  
Enass A. Abdel-Hameed ◽  
Richard L. Ehman ◽  
Susan D. Rouster ◽  
Adriana Campa ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Magnetic Resonance Elastography ◽  
Noninvasive Methods ◽  
Liver Fibrosis Index

scholarly journals Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19

2020 ◽  
Vol 222 (5) ◽  
pp. 726-733 ◽  
Author(s):  
Luis Ibáñez-Samaniego ◽  
Federico Bighelli ◽  
Clara Usón ◽  
Celia Caravaca ◽  
Carlos Fernández Carrillo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Natural History ◽  
Severe Disease ◽  
Middle Aged ◽  
Aged Patients ◽  
Reactive Protein ◽  
Risk Of Progression ◽  
Advanced Liver Fibrosis ◽  
History Of ◽  
Liver Fibrosis Index

Abstract Background COVID-19 is a potentially severe disease caused by the recently described SARS-CoV-2. Whether liver fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown. We aimed to evaluate the association between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19. Methods In this multicenter, retrospective study with prospective follow-up of 160 patients aged 35–65 years with COVID-19, FIB-4, clinical, and biochemical variables were collected at baseline. FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis. Results Risk for advanced fibrosis was estimated in 28.1% of patients. Patients with FIB-4 ≥2.67 more frequently required mechanical ventilation (37.8% vs 18.3%; P = .009). In multivariate analysis, FIB-4 ≥2.67 (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.30–8.92), cardiovascular risk factors (OR, 5.05; 95% CI, 1.90–13.39), previous respiratory diseases (OR, 4.54; 95% CI, 1.36–15.10), and C-reactive protein (OR, 1.01; 95% CI, 1.01–1.02) increased significantly the risk of ICU admission. Bootstrap confirmed FIB-4 as an independent risk factor. Conclusions In middle-aged patients with COVID-19, FIB-4 may have a prognostic role. The link between liver fibrosis and the natural history of COVID-19 should be evaluated in future studies.

scholarly journals Elevated liver fibrosis index FIB-4 is not reliable for HCC risk stratification in predominantly non-Asian CHB patients

Medicine ◽  
2016 ◽  
Vol 95 (38) ◽  
pp. e4602 ◽  
Author(s):  
Münevver Demir ◽  
Friederike Grünewald ◽  
Sonja Lang ◽  
Christoph Schramm ◽  
Andrea Bowe ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Risk Stratification ◽  
Liver Fibrosis Index

scholarly journals Liver fibrosis index as a novel prognostic factor in patients with pulmonary arterial hypertension

2021 ◽  
Author(s):  
Asuka Furukawa ◽  
Yuichi Tamura ◽  
Kenta Yamada ◽  
Hirohisa Taniguchi ◽  
Narutaka Ohashi ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Prognostic Factor ◽  
Liver Fibrosis ◽  
Arterial Hypertension ◽  
Pulmonary Arterial ◽  
Liver Fibrosis Index
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