scholarly journals Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance

2020 ◽  
Vol 4 (6) ◽  
pp. 904-915 ◽  
Author(s):  
Mark W. Douglas ◽  
Enoch S.E. Tay ◽  
Dao Sen Wang ◽  
Adrian T.L. Ong ◽  
Caroline Wilson ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Open Access ◽  
Antiviral Drug ◽  
Treatment Model ◽  
Antiviral Drug Resistance

scholarly journals Hepatitis C Virus and Antiviral Drug Resistance

Gut and Liver ◽  
2016 ◽  
Vol 10 (6) ◽  
pp. 890-895 ◽  
Author(s):  
Seungtaek Kim ◽  
Kwang-Hyub Han ◽  
Sang Hoon Ahn
Keyword(s):  
Drug Resistance ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance

Drug Resistance in Hepatitis C Virus: Future Prospects and Strategies to Combat It

2020 ◽  
Vol 30 (4) ◽  
pp. 323-336
Author(s):  
Iqra Almas ◽  
Samia Afzal ◽  
Hamna Imtiaz ◽  
Mahrukh Akbar Shaheen ◽  
Muhammad Daud ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Future Prospects

scholarly journals A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

2020 ◽  
pp. 124043 ◽  
Author(s):  
Manish Kumar ◽  
Payal Mazumder ◽  
Sanjeeb Mohapatra ◽  
Alok Kumar Thakur ◽  
Kiran Dhangar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Environmental Fate ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance

scholarly journals Prevalence of Antiviral Drug Resistance in Untreated Patients with Cytomegalovirus Retinitis

2000 ◽  
Vol 182 (4) ◽  
pp. 1234-1238 ◽  
Author(s):  
Weiqun Liu ◽  
Carol Shum ◽  
Daniel F. Martin ◽  
Baruch D. Kuppermann ◽  
Anthony J. H. Hall ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiviral Drug ◽  
Cytomegalovirus Retinitis ◽  
Antiviral Drug Resistance

scholarly journals Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

2007 ◽  
Vol 81 (13) ◽  
pp. 6909-6919 ◽  
Author(s):  
Frederik Pauwels ◽  
Wendy Mostmans ◽  
Ludo M. M. Quirynen ◽  
Liesbet van der Helm ◽  
Carlo W. Boutton ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Binding Site ◽  
Antiviral Drug ◽  
Variable Binding ◽  
Polymerase Inhibitors ◽  
Binding Site Identification ◽  
Virus Genotypes ◽  
Binding Pockets ◽  
Virus Mutant

ABSTRACT The search for hepatitis C virus polymerase inhibitors has resulted in the identification of several nonnucleoside binding pockets. The shape and nature of these binding sites differ across and even within diverse hepatitis C virus genotypes. These differences confront antiviral drug discovery with the challenge of finding compounds that are capable of inhibition in variable binding pockets. To address this, we have established a hepatitis C virus mutant and genotypic recombinant polymerase panel as a means of guiding medicinal chemistry through the elucidation of the site of action of novel inhibitors and profiling against genotypes. Using a genotype 1b backbone, we demonstrate that the recombinant P495L, M423T, M414T, and S282T mutant enzymes can be used to identify the binding site of an acyl pyrrolidine analog. We assess the inhibitory activity of this analog and other nonnucleoside inhibitors with our panel of enzyme isolates generated from clinical sera representing genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.

A Mass Spectrometry-based Method to Detect Antiviral Drug Resistance in Human Cytomegalovirus

2009 ◽  
Vol 82 (2) ◽  
pp. A51
Author(s):  
Clara Posthuma ◽  
Martha Van der Beek ◽  
Caroline Van der Blij ◽  
Willy Spaan ◽  
Louis Kroes ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Resistance ◽  
Human Cytomegalovirus ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance

Antiviral Drug Resistance in Herpesviruses

2017 ◽  
pp. 87-122 ◽  
Author(s):  
Jocelyne Piret ◽  
Emilien Drouot ◽  
Guy Boivin
Keyword(s):  
Drug Resistance ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance

Assays for antiviral drug resistance

1995 ◽  
Vol 26 (4) ◽  
pp. 403-413 ◽  
Author(s):  
David W. Kimberlin ◽  
Stephen A. Spector ◽  
Edgar L. Hill ◽  
Karen K. Biron ◽  
Alan J. Hay ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance
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