scholarly journals Interindividual Diversity in Expression of Organic Anion Uptake Transporters in Normal and Cirrhotic Human Liver

2020 ◽  
Vol 4 (5) ◽  
pp. 739-752
Author(s):  
Tatsuya Taniguchi ◽  
Alana Zanetti‐Yabur ◽  
Pijun Wang ◽  
Mykhaylo Usyk ◽  
Robert D. Burk ◽  
...  
Keyword(s):  
Human Liver ◽  
Organic Anion ◽  
Uptake Transporters ◽  
Anion Uptake

scholarly journals Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

Hepatology ◽  
2002 ◽  
Vol 36 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Stephan R. Vavricka ◽  
Jessica Van Montfoort ◽  
Huy Riem Ha ◽  
Peter J. Meier ◽  
Karin Fattinger
Keyword(s):  
Human Liver ◽  
Organic Anion ◽  
Rifamycin Sv ◽  
Anion Uptake

scholarly journals ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier

2005 ◽  
Vol 65 (24) ◽  
pp. 11419-11428 ◽  
Author(s):  
Holger Bronger ◽  
Jörg König ◽  
Kathrin Kopplow ◽  
Hans-Herbert Steiner ◽  
Rezvan Ahmadi ◽  
...  
Keyword(s):  
Organic Anion ◽  
Efflux Pumps ◽  
Drug Efflux ◽  
Human Gliomas ◽  
Drug Efflux Pumps ◽  
Uptake Transporters ◽  
Anion Uptake

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

Hepatology ◽  
1997 ◽  
Vol 26 (6) ◽  
pp. 1667-1677 ◽  
Author(s):  
P J Meier ◽  
U Eckhardt ◽  
A Schroeder ◽  
B Hagenbuch ◽  
B Stieger
Keyword(s):  
Bile Acid ◽  
Substrate Specificity ◽  
Human Liver ◽  
Organic Anion ◽  
Anion Uptake

scholarly journals Expression and Function of Organic Anion Transporting Polypeptides in the Human Brain: Physiological and Pharmacological Implications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 834
Author(s):  
Anima M. Schäfer ◽  
Henriette E. Meyer zu Schwabedissen ◽  
Markus Grube
Keyword(s):  
Organic Anion ◽  
Physiological Role ◽  
Point Of View ◽  
Efflux Transporters ◽  
Organic Anion Transporting Polypeptides ◽  
Current State ◽  
P Glycoprotein ◽  
The Central Nervous System ◽  
And Function ◽  
Uptake Transporters

The central nervous system (CNS) is an important pharmacological target, but it is very effectively protected by the blood–brain barrier (BBB), thereby impairing the efficacy of many potential active compounds as they are unable to cross this barrier. Among others, membranous efflux transporters like P-Glycoprotein are involved in the integrity of this barrier. In addition to these, however, uptake transporters have also been found to selectively uptake certain compounds into the CNS. These transporters are localized in the BBB as well as in neurons or in the choroid plexus. Among them, from a pharmacological point of view, representatives of the organic anion transporting polypeptides (OATPs) are of particular interest, as they mediate the cellular entry of a variety of different pharmaceutical compounds. Thus, OATPs in the BBB potentially offer the possibility of CNS targeting approaches. For these purposes, a profound understanding of the expression and localization of these transporters is crucial. This review therefore summarizes the current state of knowledge of the expression and localization of OATPs in the CNS, gives an overview of their possible physiological role, and outlines their possible pharmacological relevance using selected examples.

scholarly journals Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes

1996 ◽  
Vol 316 (3) ◽  
pp. 901-904 ◽  
Author(s):  
Bruno HAGENBUCH ◽  
Bruce F. SCHARSCHMIDT ◽  
Peter J. MEIER
Keyword(s):  
Bile Acid ◽  
Xenopus Laevis ◽  
Rat Liver ◽  
Antisense Oligonucleotide ◽  
Antisense Oligonucleotides ◽  
Organic Anion ◽  
Xenopus Laevis Oocytes ◽  
Acid Uptake ◽  
Uptake System ◽  
Anion Uptake

A Na+-dependent bile acid (Na+/taurocholate co-transporting polypeptide; Ntcp) and a Na+-independent bromosulphophthalein (BSP)/bile acid uptake system (organic-anion-transporting polypeptide; oatp) have been cloned from rat liver by using functional expression cloning in Xenopus laevis oocytes. To evaluate the extent to which these cloned transporters could account for overall hepatic bile acid and BSP uptake, we used antisense oligonucleotides to inhibit the expression of Ntcp and oatp in Xenopus laevis oocytes injected with total rat liver mRNA. An Ntcp-specific antisense oligonucleotide co-injected with total rat liver mRNA blocked the expression of Na+-dependent taurocholate uptake by approx. 95%. In contrast, an oatp-specific antisense oligonucleotide when co-injected with total rat liver mRNA had no effect on the expression of Na+-dependent taurocholate uptake, but it blocked Na+-independent uptake of taurocholate by approx. 80% and of BSP by 50%. Assuming similar expression of hepatocellular bile acid and organic anion transporters in Xenopus laevis oocytes, these results indicate that Ntcp and oatp respectively represent the major, if not the only, Na+-dependent and Na+-independent taurocholate uptake systems in rat liver. By contrast, the cloned oatp accounts for only half of BSP transport, suggesting that there must be additional, non-bile acid transporting organic anion uptake systems in rat liver.

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

2001 ◽  
Vol 283 (2) ◽  
pp. 417-422 ◽  
Author(s):  
William Sun ◽  
Rong Rong Wu ◽  
Paul D. van Poelje ◽  
Mark D. Erion
Keyword(s):  
Human Liver ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Liver And Kidney

Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver

2020 ◽  
Vol 17 (8) ◽  
pp. 2821-2830
Author(s):  
Ayaka Tajiri ◽  
Takeshi Hirota ◽  
Sasagu Kawano ◽  
Akira Yonamine ◽  
Ichiro Ieiri
Keyword(s):  
Human Liver ◽  
Organic Anion ◽  
Organic Anion Transporting Polypeptide
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