scholarly journals Impact of Hepatic Steatosis on Resting Metabolic Rate and Metabolic Adaptation in Response to Intentional Weight Loss

2019 ◽  
Vol 3 (10) ◽  
pp. 1347-1355
Author(s):  
Vikrant P. Rachakonda ◽  
James P. DeLany ◽  
Erin E. Kershaw ◽  
Jaideep Behari
Keyword(s):  
Weight Loss ◽  
Metabolic Rate ◽  
Hepatic Steatosis ◽  
Resting Metabolic Rate ◽  
Metabolic Adaptation ◽  
Intentional Weight Loss

scholarly journals Resting metabolic rate, fat-free mass and catecholamine excretion during weight loss in female obese patients

2000 ◽  
Vol 84 (4) ◽  
pp. 515-520 ◽  
Author(s):  
R. Menozzi ◽  
M. Bondi ◽  
A. Baldini ◽  
M. G. Venneri ◽  
A. Velardo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Metabolic Rate ◽  
Urinary Excretion ◽  
Weight Maintenance ◽  
Resting Metabolic Rate ◽  
Fat Free Mass ◽  
Metabolic Adaptation ◽  
Obese Patients ◽  
Maintenance Period ◽  
Sympathoadrenal System

The reduction in resting metabolic rate (RMR) during weight loss exceeds that accounted for by changes in body composition by 15%, suggesting that factors other than fat-free mass (FFM) explain the metabolic adaptation during food restriction in obesity. Our study aimed to establish if changes in the sympathoadrenal system activity, as inferred from an integrated measure such as 24 h urinary excretion of catecholamines, may play a role in the RMR adaptation observed during dietary restriction in obese patients. Ninety-three obese female subjects consumed a low-energy diet (LED) (2930 kJ/d (700 kcal/d)) for a 3-week period. At the beginning and at the end of the study, 24 h urinary excretion of catecholamines, FFM and RMR were measured. The LED induced a significant reduction in body weight (-3·3 (SEM 0·4) KG; P < 0·01), FFM (-1·9 (sem 0·7) kg; P < 0·01) and in the fat mass (-1·2 (sem 0·5) kg; P < 0·01). Noradrenalin excretion (24 h) decreased during the LED from 264 (sem 26) during a weight-maintenance period to 171 (sem 19) nmol/24 h after consumption of the LED for 3 weeks (P < 0·001); mean 24 h adrenalin excretion did not change during the LED (22 (sem 3) during the weight-maintenance period v. 21 (sem 3) nmol/24 h after consumption of the LED for 3 weeks; NS). The LED induced a significant decrease in RMR (7300 (sem 218) v. 6831 (sem 138) kJ/24 h; P < 0·001). The only independent variable that significantly explained variations in RMR both before and after consumption of the LED for 3 weeks, was FFM (r2 0·79 and r2 0·80 respectively). Urinary noradrenalin excretion explained a further 4 % of the variability in RMR, but only before the diet, so that a role of sympathoadrenal system on RMR seems to be present in obese patients in basal conditions but not at the end of the LED.

Association between ketosis and metabolic adaptation at the level of resting metabolic rate

2021 ◽  
Author(s):  
Catia Martins ◽  
Jessica Roekenes ◽  
Gary R. Hunter ◽  
Barbara A. Gower
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Metabolic Adaptation

scholarly journals The associations of resting metabolic rate with chronic conditions and weight loss

2017 ◽  
Vol 7 (2) ◽  
pp. 70-76 ◽  
Author(s):  
R. A. G. Christensen ◽  
L. Raiber ◽  
S. Wharton ◽  
M. A. Rotondi ◽  
J. L. Kuk
Keyword(s):  
Weight Loss ◽  
Metabolic Rate ◽  
Chronic Conditions ◽  
Resting Metabolic Rate

Weight Loss and Weight Cycling in Amateur Wrestlers: Implications for Performance and Resting Metabolic Rate

1993 ◽  
Vol 3 (3) ◽  
pp. 245-260 ◽  
Author(s):  
Craig A. Horswill
Keyword(s):  
Weight Loss ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Recovery Period ◽  
Aerobic Performance ◽  
Anaerobic Performance ◽  
Rapid Weight Loss ◽  
Weight Class ◽  
Weight Cycling ◽  
Glycogen Depletion

Amateur wrestlers practice weight loss for ergogenic reasons. The effects of rapid weight loss on aerobic performance are adverse and profound, but the effects on anaerobic performance are equivocal Anaerobic performance—strength and power—may be the most relevant type of performance to the wrestler. Maintenance of or even small decrements in anaerobic performance may translate into improvements in performance relative to the weight class, the factor by which wrestlers are matched for competition. During the recovery period between the official weigh-in and competition, wrestlers achieve at least partial nutritional recovery, which appears to benefit performance. Successive bouts of (a) weight loss to make weight and (b) recovery for performance lead to weight cycling. There is speculation that weight cycling may contribute to chronic glycogen depletion, reductions in fat-free weight, a decrease in resting metabolic rate, and an increase in body fat. The latter two would augment the difficulty of losing weight for subsequent weigh-ins. Most research indicates that the suppressed resting metabolic rate with weight loss in wrestlers appears to be transient, but subsequent research is needed for confirmation.

scholarly journals Metabolic Adaptation Delays Time to Reach Weight Loss Goals

2021 ◽  
Author(s):  
Catia Martins ◽  
Barbara Gower ◽  
Gary Hunter
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Regression Model ◽  
Resting Metabolic Rate ◽  
Premenopausal Women ◽  
Compartment Model ◽  
Metabolic Adaptation ◽  
Dietary Adherence ◽  
Weight Loss Goal ◽  
Composition Changes

Abstract BackgroundThe clinical relevance of metabolic adaptation remains to be fully determined, but its role as a driver of weight regain has been dismissed. It could be hypothesized that metabolic adaptation increases the length of time needed to reach weight loss goals. The aim of this study was, therefore, to determine if metabolic adaptation, at the level of resting metabolic rate (RMR), is associated with time to reach weight loss goals, after adjusting for confounders. Methods65 premenopausal women with overweight (BMI: 28.6±1.5 kg/m2; age: 36.4±5.9 years; 36 Whites and 29 Blacks) followed an 800 kcal/day diet until body mass index ≤25 kg/m2. Body weight and composition (4 compartment model (4CM) and dual x-ray absorptiometry (DXA)) and RMR (indirect calorimetry) were measured at baseline and after weight loss (after a 4-week weight stabilization period). Dietary adherence was calculated from total energy expenditure (TEE) determined by double labeled water measures and DXA body composition changes. Metabolic adaptation was defined as a significantly lower measured vs predicted RMR (from own regression model using 4CM data). A regression model to predict time to reach weight loss goals was developed including baseline body weight, baseline TEE, dietary adherence and metabolic adaptation as predictors. ResultsParticipants lost on average 12.5±3.1 kg (16.1±3.4%) over 155.1±49.2 days. Average dietary adherence was 63.6±31.0%. There was significant metabolic adaptation after weight loss (-46±113 kcal/day, P=0.002) and this variable was a significant predictor of time to reach weight loss goal (β=-0.1, P=0.033), even after adjusting for confounders (R2 adjusted = 0.59, P<0.001). ConclusionIn premenopausal women with overweight, metabolic adaptation after a 16% weight loss increases the length of time necessary to achieve weight loss goals. Trial registration ID (JULIET study)NCT00067873

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