scholarly journals Quantitative antibody responses to structural (core) and nonstructural (NS3, NS4, and NS5) hepatitis C virus proteins among seroconverting injecting drug users: Impact of epitope variation and relationship to detection of HCV RNA in blood

Hepatology ◽  
1999 ◽  
Vol 29 (4) ◽  
pp. 1288-1298 ◽  
Author(s):  
Marcel Beld ◽  
Maarten Penning ◽  
Marieke van Putten ◽  
Vladimir Lukashov ◽  
Anneke van den Hoek ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Injecting Drug Users ◽  
Antibody Responses ◽  
Hcv Rna ◽  
Hepatitis C Virus Proteins ◽  
Virus Proteins

Hepatitis C virus replication and antibody responses toward specific hepatitis C virus proteins

Hepatology ◽  
1994 ◽  
Vol 19 (6) ◽  
pp. 1360-1365 ◽  
Author(s):  
Nobukazu Yuki ◽  
Norio Hayashi ◽  
Akinori Kasahara ◽  
Hideki Hagiwara ◽  
Kazuyoshi Ohkawa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Antibody Responses ◽  
Hepatitis C Virus Proteins ◽  
Virus Proteins

scholarly journals Risk factors for hepatitis C virus infection among injecting drug users in Sydney.

1994 ◽  
Vol 70 (5) ◽  
pp. 321-324 ◽  
Author(s):  
I van Beek ◽  
R Buckley ◽  
M Stewart ◽  
M MacDonald ◽  
J Kaldor
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Drug Users ◽  
Injecting Drug Users ◽  
Hepatitis C Virus Infection

Prevalence and incidence of hepatitis C in injecting drug users attending genitourinary medicine clinics

2008 ◽  
Vol 137 (7) ◽  
pp. 980-987 ◽  
Author(s):  
M. A. BALOGUN ◽  
N. MURPHY ◽  
S. NUNN ◽  
A. GRANT ◽  
N. J. ANDREWS ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Drug Users ◽  
Multivariable Analysis ◽  
Injecting Drug Users ◽  
Hcv Rna ◽  
Cross Sectional ◽  
Prevalence Studies ◽  
Genitourinary Medicine ◽  
Cross Sectional Design ◽  
Type 3

SUMMARYSurveillance reports and prevalence studies have indicated that injecting drug users (IDUs) contribute more to the hepatitis C epidemic in the United Kingdom than any other risk group. Information on both the prevalence and incidence of hepatitis C in IDUs is therefore essential to understanding the epidemiology of this infection. The prevalence of hepatitis C in specimens from the Unlinked Anonymous Prevalence Monitoring Programme collected in 1995, 1996, 1998, 1999, 2000, and 2001 was determined using residual syphilis serology specimens from IDUs attending 15 genitourinary medicine (GUM) clinics in and outside London. These specimens were tested for antibodies to hepatitis C virus (anti-HCV). Using this cross-sectional design, anti-HCV-negative specimens were tested for HCV RNA to identify incident infections during the ‘window’ period of infection, and thus to estimate HCV incidence. Results of the multivariable analysis showed that there was marked variation in prevalence by clinic (P<0·0001) and age (P<0·0001). Overall the majority of infections were in males and the overall prevalence in injectors declined over the study period from 36·9% to 28·7%. The annual incidence in these injectors was estimated as being 3·01% (95% CI 1·25–6·73). Over the study period HCV incidence decreased by 1·2% per year. Genotyping of the incident infections identified the most common genotype as type 1 with type 3 being more frequently seen after 1998. Of the prevalent infections, genotype 1 was the most common. The study has confirmed a higher prevalence of anti-HCV in IDUs in the London area compared to those outside London. How representative of the current injecting drug user population are IDUs attending GUM clinics is unclear. Even so, such studies allow prevalence and incidence to be estimated in individuals who have ever injected drugs and inform ongoing public health surveillance.

scholarly journals Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil

2010 ◽  
Vol 105 (3) ◽  
pp. 299-303 ◽  
Author(s):  
Maria Betânia S Silva ◽  
Tarcísio M Andrade ◽  
Luciano K Silva ◽  
Itatiana F Rodart ◽  
Gisele B Lopes ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Injecting Drug Users

scholarly journals Adherence to treatment for recently acquired hepatitis C virus (HCV) infection among injecting drug users

2011 ◽  
Vol 55 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Jason Grebely ◽  
Gail V. Matthews ◽  
Margaret Hellard ◽  
David Shaw ◽  
Ingrid van Beek ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Injecting Drug Users ◽  
Hcv Infection ◽  
Adherence To Treatment

The hepatitis C virus epidemic among injecting drug users

2005 ◽  
Vol 5 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Oliver G. Pybus ◽  
Alexandra Cochrane ◽  
Edward C. Holmes ◽  
Peter Simmonds
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Injecting Drug Users

Expression of hepatitis c virus proteins inhibits interferon α signaling in the liver of transgenic mice

2003 ◽  
Vol 124 (5) ◽  
pp. 1465-1475 ◽  
Author(s):  
Alex Blindenbacher ◽  
Francois H.T. Duong ◽  
Lukas Hunziker ◽  
Simone T.D. Stutvoet ◽  
Xueya Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Transgenic Mice ◽  
Interferon Α ◽  
Hepatitis C Virus Proteins ◽  
Virus Proteins
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