scholarly journals In vitro evidence for the presence of hematopoietic stem cells in the adult human liver

Hepatology ◽  
1999 ◽  
Vol 29 (4) ◽  
pp. 1193-1198 ◽  
Author(s):  
Orla M. Crosbie ◽  
Maura Reynolds ◽  
Gerry McEntee ◽  
Oscar Traynor ◽  
John E. Hegarty ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Human Liver ◽  
Hematopoietic Stem ◽  
Adult Human

Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells

2003 ◽  
Vol 191 (2) ◽  
pp. 95-106 ◽  
Author(s):  
James L Gardner ◽  
Adriana M Doi ◽  
Robert T Pham ◽  
Christiaan M Huisden ◽  
Evan P Gallagher
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Human Liver ◽  
Hematopoietic Stem

scholarly journals Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver

Hepatology ◽  
2000 ◽  
Vol 31 (6) ◽  
pp. 1251-1256 ◽  
Author(s):  
Lucy Golden-Mason ◽  
Michael P. Curry ◽  
Niamh Nolan ◽  
Oscar Traynor ◽  
Gerry McEntee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Differential Expression ◽  
Human Liver ◽  
Hematopoietic Stem ◽  
Adult Human ◽  
Tumor Bearing

Strategies to Protect Hematopoietic Stem Cells from Culture-Induced Stress Conditions

2020 ◽  
Vol 15 ◽  
Author(s):  
Fatima Aerts-Kaya
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Ex Vivo ◽  
Stress Conditions ◽  
Stress Factors ◽  
Hematopoietic Stem ◽  
Induced Stress

: In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expansion and differentiation of HSCs will enable the development of better protocols for expansion of HSCs. This will allow procurement of HSCs with long-term engraftment potential and a better understanding of the effects of the external influences in and on the hematopoietic niche that may affect HSC function. During collection and culture of HSCs, the cells are exposed to suboptimal conditions that may induce different levels of stress and ultimately affect their self-renewal, differentiation and long-term engraftment potential. Some of these stress factors include normoxia, oxidative stress, extra-physiologic oxygen shock/stress (EPHOSS), endoplasmic reticulum (ER) stress, replicative stress, and stress related to DNA damage. Coping with these stress factors may help reduce the negative effects of cell culture on HSC potential, provide a better understanding of the true impact of certain treatments in the absence of confounding stress factors. This may facilitate the development of better ex vivo expansion protocols of HSCs with long-term engraftment potential without induction of stem cell exhaustion by cellular senescence or loss of cell viability. This review summarizes some of available strategies that may be used to protect HSCs from culture-induced stress conditions.

EXPANSION OF HEMATOPOIETIC STEM CELLS IN VITRO AS A MODEL SYSTEM FOR HUMAN TISSUE ENGINEERING

2000 ◽  
Vol 31 (3) ◽  
pp. 499-509 ◽  
Author(s):  
Joel S. Greenberger ◽  
Julie P. Goff ◽  
Jason Bush ◽  
Alfred Bahnson ◽  
Douglas Koebler ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Human Tissue ◽  
Model System ◽  
Hematopoietic Stem

3040 – IN VITRO RECAPITULATION OF MURINE T CELL DEVELOPMENT FROM SINGLE HEMATOPOIETIC STEM CELLS

2020 ◽  
Vol 88 ◽  
pp. S51
Author(s):  
Victoria Sun ◽  
Amelie Montel-Hagen ◽  
David Casero ◽  
Steven Tsai ◽  
Alexandre Zampieri ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cell ◽  
Hematopoietic Stem Cells ◽  
T Cell Development ◽  
Cell Development ◽  
Hematopoietic Stem
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