scholarly journals Decreased survival in rat liver transplantation with extended cold preservation: Role of portal vein clamping time

Hepatology ◽  
1998 ◽  
Vol 28 (2) ◽  
pp. 366-373 ◽  
Author(s):  
Koichi Urata ◽  
Bich Nguyen ◽  
Antoine Brault ◽  
Jo�l Lavoie ◽  
Bernard Rocheleau ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Portal Vein ◽  
Rat Liver ◽  
Cold Preservation ◽  
Rat Liver Transplantation ◽  
Portal Vein Clamping

Role of the bcl-2/bax pathway in hepatocyte apoptosis during acute rejection after rat liver transplantation

1998 ◽  
Vol 11 (0) ◽  
pp. S179-S184 ◽  
Author(s):  
H. Yamamoto ◽  
H. Ohdan ◽  
S. Shintaku ◽  
T. Asahara ◽  
H. Ito ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Rat Liver ◽  
Hepatocyte Apoptosis ◽  
Rat Liver Transplantation

Role of donor passenger leukocytes on the induction of tolerance in rat liver transplantation

1998 ◽  
Vol 30 (7) ◽  
pp. 3852-3853 ◽  
Author(s):  
S Chiba ◽  
S Goto ◽  
R Lord ◽  
Y Shimizu ◽  
S Kobayashi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Rat Liver ◽  
Rat Liver Transplantation ◽  
Passenger Leukocytes ◽  
Induction Of Tolerance

Protective Role of the L-Arginine-Nitric Oxide Synthase Pathway on Preservation Injury after Rat Liver Transplantation

2001 ◽  
Vol 25 (3) ◽  
pp. 142-147 ◽  
Author(s):  
David A. Geller ◽  
Stanley H. Chia ◽  
Yoshihito Takahashi ◽  
Gautam P. Yagnik ◽  
George Tsoulfas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Transplantation ◽  
Nitric Oxide Synthase ◽  
Rat Liver ◽  
Protective Role ◽  
Rat Liver Transplantation ◽  
Preservation Injury ◽  
Oxide Synthase

The Role of Tacrolimus Nanomicelles in Acute Rejection After Liver Transplantation in Rats

2021 ◽  
Vol 21 (2) ◽  
pp. 1061-1069
Author(s):  
Zhantao Xie ◽  
Huibo Zhao ◽  
Yuan Chen ◽  
Sidong Wei ◽  
Jianjun Sun ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Animal Model ◽  
Acute Rejection ◽  
Rat Liver ◽  
Brown Norway ◽  
Rat Liver Transplantation ◽  
Transplantation Model

Although there is some progress in immunosuppressive therapy of acute rejection, there is still a lack of standardized diagnosis and treatment. For the acute rejection after liver transplantation, there is still a lack of an exact treatment at this stage. Tacrolimus (TAC) side effects will also affect the survival rate and quality of life of recipients after transplantation to a large extent. Rat orthotopic liver transplantation model was established and divided into three groups. In the tolerance group, Brown Norway (BN) to Lewis liver transplantation was used; in the rejection group, Lewis to BN liver transplantation was used; in the TAC group, TAC was injected after operation on the basis of establishing rejection model. The expression of GITRL in Kupffer cells and the change of cytokines were detected 7 days after operation. In this study, the animal model of acute rejection of rat liver transplantation was established to simulate the clinical allogeneic liver transplantation, and the important role of TAC in the acute rejection of rat liver transplantation was evaluated.

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