scholarly journals Precore wild-type DNA and immune complexes persist in chronic hepatitis B after seroconversion: No association between genome conversion and seroconversion

Hepatology ◽  
1998 ◽  
Vol 27 (1) ◽  
pp. 245-253 ◽  
Author(s):  
Toshiyuki Maruyama ◽  
Shoji Kuwata ◽  
Kazuhiko Koike ◽  
Shiro Iino ◽  
Kiyomi Yasuda ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Immune Complexes ◽  
Wild Type

Wild-type and HBeAg-minus HBV Fluctuations: Cause or Effect of Chronic Hepatitis B Pathogenic Mechanisms?

1994 ◽  
pp. 261-264
Author(s):  
Maurizia Rossana Brunetto ◽  
Gabriella Capra ◽  
Anna Randone ◽  
Pierluigi Calvo ◽  
Cristiana Barbera ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Wild Type ◽  
Pathogenic Mechanisms

Wild-type and “o” antigen minus hepatitis B viruses and course of chronic hepatitis B in children

1991 ◽  
Vol 13 ◽  
pp. S7
Author(s):  
C. Barbera ◽  
M. Giarin ◽  
T. Parrella ◽  
M. Abate ◽  
F. Bonino ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Wild Type ◽  
O Antigen

Wild‐type precore and core promoter sequences in patients with acute self‐limited or chronic hepatitis B

2004 ◽  
Vol 39 (1) ◽  
pp. 53-59 ◽  
Author(s):  
M. Kobayashi ◽  
Y. Arase ◽  
K. Ikeda ◽  
A. Tsubota ◽  
Y. Suzuki ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Core Promoter ◽  
Wild Type ◽  
Promoter Sequences

scholarly journals The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1664
Author(s):  
Ednelza da Silva Graça Amoras ◽  
William Botelho de Brito ◽  
Maria Alice Freitas Queiroz ◽  
Simone Regina Souza da Silva Conde ◽  
Izaura Maria Vieira Cayres Vallinoto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Disease Stage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Genetic Profile ◽  
Wild Type ◽  
Susceptibility To Infection ◽  
Increased Risk

The present study evaluated the IL8-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The IL8-251 A/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation (p = 0.0464) and fibrosis scores (p = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity (OR = 1.84; p = 0.0464) and for high fibrosis scores (OR = 2.63; p = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the IL8-251 A/T polymorphism than in those with the wild-type genotype (p = 0.0272 and p = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group (p = 0.0445 and p = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group (p = 0.0239) and the HCV group (p = 0.0372). The wild-type genotype for IL8-251 A/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases.

Comparison of replication competence of wild-type and lamivudine-resistant hepatitis B virus isolates from a chronic hepatitis B patient

2018 ◽  
Vol 255 ◽  
pp. 165-170 ◽  
Author(s):  
Quan Zhang ◽  
Junhao Chen ◽  
Mingjie Pan ◽  
Jingli Liu ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Wild Type ◽  
B Virus ◽  
Virus Isolates
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