Antibodies to single-stranded and double-stranded DNA in antinuclear antibody-positive type 1-autoimmune hepatitis

Hepatology ◽  
1997 ◽  
Vol 26 (3) ◽  
pp. 567-572 ◽  
Author(s):  
A J Czaja ◽  
S A Morshed ◽  
S Parveen ◽  
M Nishioka
Keyword(s):  
Autoimmune Hepatitis ◽  
Antinuclear Antibody ◽  
Positive Type ◽  
Double Stranded Dna

scholarly journals Decompensated Cirrhosis as Presentation of LKM1/LC1 Positive Type 2 Autoimmune Hepatitis in Adulthood. A Rare Clinical Entity of Difficult Management

2021 ◽  
Vol 12 (1) ◽  
pp. 67-75
Author(s):  
Alessandro Granito ◽  
Simona Pascolini ◽  
Chiara Ricci ◽  
Marco Ferronato ◽  
Luigi Muratori ◽  
...  
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Immunosuppressive Therapy ◽  
Clinical Signs ◽  
Decompensated Cirrhosis ◽  
Positive Type ◽  
Curative Therapy ◽  
End Stage

Background: Autoimmune hepatitis (AIH) is a chronic and aggressive liver disease that rapidly evolves into cirrhosis and end-stage liver disease if not timely diagnosed and treated with immunosuppressive therapy. AIH is classified into type 1 and type 2 according to the autoantibody pattern, with smooth muscle antibodies and/or antinuclear antibodies as serological markers of AIH-1, while antiliver cytosol antibody type 1 and/or antiliver/kidney microsomal antibody type 1 characterize type 2 AIH, which mainly affects children, including infants, and adolescents. Case Summary: We describe a case of type 2 AIH, clinically onset in a 34-year-old woman with decompensated cirrhosis. Only a thorough analysis of the autoantibody profile allowed for a diagnosis of an AIH-2 evolved into cirrhosis. The patient received a moderate corticosteroid therapy without achieving optimal disease control. We discuss the controversial decision of whether or not to treat the patient with immunosuppressive therapy, which should be balanced with the potential risk of infectious and other complications. A review of the literature on the management of patients with autoimmune cirrhosis is also presented. Conclusions: AIH-2 can be clinically onset in adult patients with cirrhosis and its complications, without being preceded by major clinical signs. Due to the difficult management of cirrhosis with immunosuppressive treatments, a patient-tailored strategy with a case-by-case approach is needed to prevent major complications such as infections, potentially precluding liver transplantation the only curative therapy.

Antibodies to double-stranded DNA (ANTI-DSDNA) in type 1 autoimmune hepatitis (AIH-1)

2006 ◽  
Vol 38 (9) ◽  
pp. A76
Author(s):  
G. Pappas ◽  
A. Granito ◽  
M. Guidi ◽  
P. Muratori ◽  
L. Muratori ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Double Stranded Dna

Citrulline-independent positivity of anti cyclic citrullinated peptide antibodiES (ANTI-CCP) in type 1 autoimmune hepatitis (AIH-1)

2006 ◽  
Vol 38 (9) ◽  
pp. A83-A84
Author(s):  
A. Vannini ◽  
A.J.W. Zendman ◽  
A.C. Dall’Aglio ◽  
G. Ballardini ◽  
D. Zauli ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Cyclic Citrullinated Peptide ◽  
Citrullinated Peptide ◽  
Peptide Antibodies

scholarly journals Development and validation of a prognostic score for long‐term transplant‐free survival in autoimmune hepatitis type 1

2021 ◽  
Author(s):  
Maaike Biewenga ◽  
Xavier P.D.M.J. Verhelst ◽  
Martine A.M.C. Baven‐Pronk ◽  
Hein Putter ◽  
Aad P. Berg ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Prognostic Score ◽  
Free Survival ◽  
Development And Validation ◽  
Autoimmune Hepatitis Type 1

Different HLA Profiles Confer Susceptibility to Autoimmune Hepatitis Type 1 and 2

1998 ◽  
Vol 93 (8) ◽  
pp. 1394-1395 ◽  
Author(s):  
Paulo L. Bittencourt ◽  
Anna C. Goldberg ◽  
Eduardo L. R. Cancado ◽  
Gilda Porta ◽  
Antonio A. Laudanna ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Autoimmune Hepatitis Type 1
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