scholarly journals Effect of ileal autotransplantation on cholesterol, bile acids, and biliary lipids in pigs with proximal small bowel resection

Hepatology ◽  
1997 ◽  
Vol 25 (6) ◽  
pp. 1315-1322 ◽  
Author(s):  
M Pakarinen ◽  
T A Miettinen ◽  
P Kuusanmaki ◽  
P Vento ◽  
T Kivisto ◽  
...  
Keyword(s):  
Small Bowel ◽  
Bile Acids ◽  
Bowel Resection ◽  
Small Bowel Resection ◽  
Biliary Lipids ◽  
Proximal Small Bowel

Somatostatin receptor-effector system in rat pancreatic acinar membranes after subtotal enterectomy

1995 ◽  
Vol 268 (2) ◽  
pp. E343-E348
Author(s):  
I. Alvaro-Alonso ◽  
B. Colas ◽  
J. P. Esteve ◽  
C. Susini ◽  
E. Arilla
Keyword(s):  
Small Bowel ◽  
Receptor Binding ◽  
Protein Interactions ◽  
Bowel Resection ◽  
Somatostatin Receptor ◽  
Small Bowel Resection ◽  
Receptor Binding Site ◽  
Proximal Small Bowel ◽  
Effector System ◽  
Receptor Number

In the present study we found that exocrine pancreatic hyperplasia observed after proximal small bowel resection is accompanied by an increase in pancreatic somatostatin (SS) content at 1 mo and an increase in the number of SS receptors at 2 wk and 1 mo after intestinal surgery. At 6 mo after small bowel resection SS content and SS receptors had returned to control values. However, the original increase in SS receptor number was accompanied by a decrease in the ability of SS to inhibit forskolin-stimulated adenylyl cyclase (AC) activity. In addition, the ability of 5'-guanylylimidodiphosphate (a nonhydrolyzable GTP analogue) to inhibit SS receptor binding was decreased in pancreatic acinar membranes from enterectomized rats at 2 wk and 1 mo after jejunoileal resection. These data suggest that there is an abnormality in the integrity of SS receptor binding site-G protein interactions and would explain the decreased inactivation of AC by SS at 2 wk and 1 mo after proximal small bowel resection.

scholarly journals High-Fat Diet Enhances Villus Growth During the Adaptation Response to Massive Proximal Small Bowel Resection

2013 ◽  
Vol 18 (2) ◽  
pp. 286-294 ◽  
Author(s):  
Pamela M. Choi ◽  
Raphael C. Sun ◽  
Jun Guo ◽  
Christopher R. Erwin ◽  
Brad W. Warner
Keyword(s):  
Small Bowel ◽  
High Fat Diet ◽  
Bowel Resection ◽  
Small Bowel Resection ◽  
High Fat ◽  
Proximal Small Bowel ◽  
Adaptation Response

Effects of bile and pancreatic secretions on intestinal mucosa after proximal small bowel resection in rats

1980 ◽  
Vol 58 (9) ◽  
pp. 1117-1123 ◽  
Author(s):  
Monique D. Gélinas ◽  
Claude L. Morin
Keyword(s):  
Small Intestine ◽  
Small Bowel ◽  
Pancreatic Juice ◽  
Bowel Resection ◽  
Intestinal Resection ◽  
Small Bowel Resection ◽  
Sprague Dawley ◽  
Ileal Mucosa ◽  
Distal Small Intestine ◽  
Proximal Small Bowel

After proximal small bowel resection the remaining small intestine undergoes adaptive hyperplasia. In the present study, the relative contributions of bile and (or) pancreatic juice to adaptive intestinal hyperplasia following proximal resection was studied. Using male Sprague–Dawley rats a 50% proximal intestinal resection was done starting 10 cm distal to the beginning of the jejunum. The animals were also subjected to diversion of bile and (or) pancreatic secretions to the distal ileum at 18 cm proximal to the ileocecal junction. After 8 days gut and mucosal weights, mucosal proteins, and DNA were measured in the duodenojejunum (gut segment proximal to the resection anastomosis) and in the ileum (first half of the small bowel segment distal to the diversion site). The results indicate that (1) in rats fed either chow (Purina rat chow) or a chemically defined diet diversion of pancreaticobiliary secretions to the ileum significantly stimulated ileal mucosa growth whereas no changes were observed in the duodenojejunum, (2) in rats fed a chemically defined diet neither bile nor pancreatic juice affected ileal mucosa when separately diverted to the ileum, and (3) pancreatic juice draining into the duodenum while bile was diverted to the ileum induced hypoplastic changes in the duodenojejunum. The present study suggests that following jejunectomy the regulation of mucosal growth by pancreatic and bile secretions is different in the proximal and distal small intestine. Pancreaticobiliary secretions are trophic for the ileum. However, in the proximal gut bile offers protection against a direct or indirect catabolic action of pancreatic juice.

scholarly journals Experimental colonic carcinogenesis: changes in faecal bile acids after promotion of intestinal tumours by small bowel resection in the rat.

Gut ◽  
1988 ◽  
Vol 29 (4) ◽  
pp. 495-502 ◽  
Author(s):  
A P Savage ◽  
M S Sian ◽  
J L Matthews ◽  
S R Bloom ◽  
T Cooke
Keyword(s):  
Small Bowel ◽  
Bile Acids ◽  
Bowel Resection ◽  
Small Bowel Resection ◽  
Colonic Carcinogenesis

Effect of ageing on pancreatic hyperplasia after 90% proximal small bowel resection

1997 ◽  
Vol 12 (5) ◽  
pp. 376-381 ◽  
Author(s):  
MASAYA SASAKI ◽  
KENICHIRO SAKAMOTO ◽  
YOSHIHIDE FUJIYAMA ◽  
TADAO BAMBA
Keyword(s):  
Small Bowel ◽  
Bowel Resection ◽  
Small Bowel Resection ◽  
Proximal Small Bowel

Peptide absorption after massive proximal small bowel resection: Mechanisms of ileal adaptation

2009 ◽  
Vol 209 (3) ◽  
pp. S13-S14 ◽  
Author(s):  
Hisham G. Qandeel ◽  
David J. Hernandez ◽  
Fernando Alonso ◽  
Judith A. Duenes ◽  
Ye Zheng ◽  
...  
Keyword(s):  
Small Bowel ◽  
Bowel Resection ◽  
Small Bowel Resection ◽  
Peptide Absorption ◽  
Proximal Small Bowel
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