Reply; Transcriptomics identify thrombospondin‐2 as a biomarker for nonalcoholic steatohepatitis and advanced liver fibrosis

Hepatology ◽  
2021 ◽  
Author(s):  
Takahiro Kodama ◽  
Tetsuo Takehara
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Advanced Liver Fibrosis

scholarly journals Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis

2017 ◽  
Vol 177 (5) ◽  
pp. 633 ◽  
Author(s):  
Giovanni Musso ◽  
Maurizio Cassader ◽  
Elena Paschetta ◽  
Roberto Gambino
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Advanced Liver Fibrosis

Serum aldo–keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis

2019 ◽  
Vol 54 (6) ◽  
pp. 549-557 ◽  
Author(s):  
Masataka Kanno ◽  
Kazunori Kawaguchi ◽  
Masao Honda ◽  
Rika Horii ◽  
Hajime Takatori ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Advanced Liver Fibrosis ◽  
Fatal Complications

Sa1559 – Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis (NASH) is Associated with Low Levels of Key Members of Membrane Attack Complex

2019 ◽  
Vol 156 (6) ◽  
pp. S-1234
Author(s):  
Azza Karrar ◽  
Elzafir Elsheikh ◽  
Bijal Rajput ◽  
Katherine Acosta ◽  
James Paik ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Membrane Attack Complex ◽  
Advanced Liver Fibrosis ◽  
Low Levels

scholarly journals Transcriptomics Identify Thrombospondin‐2 as a Biomarker for Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis

Hepatology ◽  
2021 ◽  
Author(s):  
Kazuhiro Kozumi ◽  
Takahiro Kodama ◽  
Hiroki Murai ◽  
Sadatsugu Sakane ◽  
Olivier Govaere ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Advanced Liver Fibrosis

Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis

2019 ◽  
Vol 17 (9) ◽  
pp. 1867-1876.e3 ◽  
Author(s):  
Rohit Loomba ◽  
Anjali Jain ◽  
Anna Mae Diehl ◽  
Cynthia D. Guy ◽  
Dana Portenier ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Serum Test ◽  
Advanced Liver Fibrosis

scholarly journals Prediction of Nonalcoholic Fatty Liver Disease Using Noninvasive and Non-Imaging Procedures in Japanese Health Checkup Examinees

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 132
Author(s):  
Kenichiro Murayama ◽  
Michiaki Okada ◽  
Kenichi Tanaka ◽  
Chika Inadomi ◽  
Wataru Yoshioka ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Japanese Population ◽  
Fatty Liver Disease ◽  
Health Checkup ◽  
Nonalcoholic Fatty Liver ◽  
General Japanese Population ◽  
Advanced Liver Fibrosis ◽  
Zju Index

Access to imaging is limited for diagnosing nonalcoholic fatty liver disease (NAFLD) in general populations. This study evaluated the diagnostic performance of noninvasive and nonimaging indexes to predict NAFLD in the general Japanese population. Health checkup examinees without hepatitis virus infection or habitual alcohol drinking were included. Fatty liver was diagnosed by ultrasonography. The hepatic steatosis index (HSI), Zhejiang University (ZJU) index, and fatty liver index (FLI) were determined, and risk of advanced liver fibrosis was evaluated by the fibrosis-4 index. NAFLD was diagnosed in 1935 (28.0%) of the 6927 subjects. The area under the receiver operating characteristic (AUROC) curve of the HSI, ZJU index, and FLI was 0.874, 0.886, and 0.884, respectively. The AUROC of the ZJU index (p < 0.001) and FLI (p = 0.002) was significantly greater than that for the HSI. In subjects with a high risk of advanced fibrosis, the sensitivity of the HSI, ZJU index, and FLI were 88.8%, 94.4%, and 83.3% with a low cut-off value and the specificity was 98.5%, 100%, and 100% with a high cut-off value. In conclusion, all indexes were useful to diagnose NAFLD in the general Japanese population and in subjects with potentially advanced liver fibrosis.

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