scholarly journals Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity

Hepatology ◽  
2021 ◽  
Author(s):  
Luc J.W. van der Laan ◽  
Floris J.M. Roos ◽  
Monique M.A. Verstegen
Keyword(s):  
Bile Duct ◽  
Human Liver ◽  
Bile Duct Repair

scholarly journals Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

2011 ◽  
Vol 11 (1) ◽  
pp. 56 ◽  
Author(s):  
Peter S Vestentoft ◽  
Peter Jelnes ◽  
Branden M Hopkinson ◽  
Ben Vainer ◽  
Kjeld Møllgård ◽  
...  
Keyword(s):  
Bile Duct ◽  
Human Liver ◽  
Intrahepatic Bile Duct ◽  
Three Dimensional

1,2-Dichloropropane and its metabolites display genotoxicity in human liver- and bile duct-derived cells

2016 ◽  
Vol 259 ◽  
pp. S179
Author(s):  
R.S. Wang ◽  
T. Toyooka ◽  
Y. Yanagiba ◽  
M. Suda
Keyword(s):  
Bile Duct ◽  
Human Liver

Simultaneous segmental obstruction of bile duct and portal vein markedly changes a population of biliary and hepatic cells in human liver

2003 ◽  
Vol 388 (4) ◽  
pp. 270-275 ◽  
Author(s):  
Takanori Kyokane ◽  
Masato Nagino ◽  
Junichi Kamiya ◽  
Yuji Nimura ◽  
Tetsuro Nagasaka
Keyword(s):  
Bile Duct ◽  
Portal Vein ◽  
Human Liver ◽  
Hepatic Cells

INFLUENCE OF POSITIVE LYMPHOCYTE CROSSMATCH AND HLA MISMATCHING ON VANISHING BILE DUCT SYNDROME IN HUMAN LIVER ALLOGRAFTS

1988 ◽  
Vol 45 (2) ◽  
pp. 376-379 ◽  
Author(s):  
Kenneth P. Batts ◽  
S. Breanndan Moore ◽  
James D. Perkins ◽  
Russell H. Wiesner ◽  
Patricia M. Grambsch ◽  
...  
Keyword(s):  
Bile Duct ◽  
Human Liver ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Human Liver Allografts ◽  
Duct Syndrome

Rubber tube stent in common bile duct repair

1965 ◽  
Vol 110 (3) ◽  
pp. 466-469 ◽  
Author(s):  
Frederick Menick ◽  
Matthew C.C. Kim
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Rubber Tube ◽  
Bile Duct Repair

scholarly journals Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication and its comparison with SARS-CoV

2021 ◽  
Author(s):  
Vincent Chi-Hang Lui ◽  
Kenrie Pui-Yan Hui ◽  
Rosanna Ottakandathil Babu ◽  
Haibing Yue ◽  
Patrick Ho-Yu Chung ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Human Liver ◽  
Liver Enzymes ◽  
Hepatic Bile ◽  
Hepatic Bile Duct ◽  
Duct Cells ◽  
Parenchymal Liver ◽  
Severe Liver Disease ◽  
Efficient Viral Replication

AbstractBackgroundAlthough the main route of infection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory tract, liver injury is also commonly seen in many patients, as evidenced by deranged parenchymal liver enzymes. Furthermore, patients with severe liver disease have been shown to have higher mortality. Overall, the mechanism behind the liver injury remains unclear.Approach and resultsWe showed that intra-hepatic bile duct cells could be grown using a human liver organoid platform. The cholangiocytes were not only susceptible to SARS-CoV-2 infection, they also supported efficient viral replication. We also showed that SARS-CoV-2 replication was much higher than SARS-CoV.ConclusionOur findings suggested direct cytopathic viral damage being a mechanism for SARS-CoV-2 liver injury.

Sign in / Sign up

Export Citation Format

Share Document