Farnesoid X receptor activation impairs liver progenitor cell‐mediated liver regeneration via the PTEN‐PI3K‐AKT‐mTOR axis in zebrafish

Hepatology ◽  
2020 ◽  
Author(s):  
Kyounghwa Jung ◽  
Minwook Kim ◽  
Juhoon So ◽  
Seung‐Hoon Lee ◽  
Sungjin Ko ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Receptor Activation ◽  
Farnesoid X Receptor ◽  
Liver Progenitor Cell

scholarly journals Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish

2018 ◽  
Vol 18 (3) ◽  
pp. 157-170 ◽  
Author(s):  
Mehwish Khaliq ◽  
Sungjin Ko ◽  
Yinzi Liu ◽  
Hualin Wang ◽  
Yonghua Sun ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Liver Progenitor Cell

scholarly journals Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

Hepatology ◽  
2015 ◽  
Vol 62 (4) ◽  
pp. 1272-1284 ◽  
Author(s):  
Caryn L. Elsegood ◽  
Chun Wei Chan ◽  
Mariapia A. Degli-Esposti ◽  
Matthew E. Wikstrom ◽  
Alice Domenichini ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Kupffer Cell ◽  
Progenitor Cell ◽  
Murine Liver ◽  
Liver Progenitor Cell

Attenuating the EGFR‐ERK‐SOX9 axis promotes liver progenitor cell‐mediated liver regeneration in zebrafish

Hepatology ◽  
2020 ◽  
Author(s):  
Juhoon So ◽  
Minwook Kim ◽  
Seung‐Hoon Lee ◽  
Sungjin Ko ◽  
Daniel A. Lee ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Liver Progenitor Cell

scholarly journals Liver progenitor cell-driven liver regeneration

2020 ◽  
Vol 52 (8) ◽  
pp. 1230-1238 ◽  
Author(s):  
Juhoon So ◽  
Angie Kim ◽  
Seung-Hoon Lee ◽  
Donghun Shin
Keyword(s):  
Animal Models ◽  
Liver Regeneration ◽  
Liver Diseases ◽  
Progenitor Cell ◽  
Current Knowledge ◽  
The Other ◽  
Severe Liver ◽  
Regenerative Capacity ◽  
Liver Progenitor Cell ◽  
Secondary Mode

Abstract The liver is a highly regenerative organ, but its regenerative capacity is compromised in severe liver diseases. Hepatocyte-driven liver regeneration that involves the proliferation of preexisting hepatocytes is a primary regeneration mode. On the other hand, liver progenitor cell (LPC)-driven liver regeneration that involves dedifferentiation of biliary epithelial cells or hepatocytes into LPCs, LPC proliferation, and subsequent differentiation of LPCs into hepatocytes is a secondary mode. This secondary mode plays a significant role in liver regeneration when the primary mode does not effectively work, as observed in severe liver injury settings. Thus, promoting LPC-driven liver regeneration may be clinically beneficial to patients with severe liver diseases. In this review, we describe the current understanding of LPC-driven liver regeneration by exploring current knowledge on the activation, origin, and roles of LPCs during regeneration. We also describe animal models used to study LPC-driven liver regeneration, given their potential to further deepen our understanding of the regeneration process. This understanding will eventually contribute to developing strategies to promote LPC-driven liver regeneration in patients with severe liver diseases.

scholarly journals FXR activation impairs liver progenitor cell‐driven liver regeneration by enhancing PTEN‐dependent inhibition of AKT‐mTOR axis

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Sungjin Ko ◽  
Kyounghwa Jung ◽  
Jacquelyn O. Russell ◽  
Min‐wook Kim ◽  
Juhoon So ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Dependent Inhibition ◽  
Liver Progenitor Cell
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