Letter to the Editor: Post‐Liver Transplantation Sinusoidal Obstruction Syndrome and immunosuppressive drugs: causality of MMF or tacrolimus?

Hepatology ◽  
2020 ◽  
Author(s):  
Véronique Loustaud‐Ratti ◽  
Alicia Anneraud ◽  
Paul Carrier ◽  
Marilyne Debette‐Gratien ◽  
Anne De Muret ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Mingjie Ding ◽  
Yuting He ◽  
Shuijun Zhang ◽  
Wenzhi Guo

Liver transplantation is an effective therapy for end-stage liver disease. However, most postoperative patients must take immunosuppressive drugs to prevent organ rejection. Interestingly, some transplant recipients have normal liver function and do not experience organ rejection after the withdrawal of immunosuppressive agents. This phenomenon, called immune tolerance, is the ultimate goal in clinical transplantation. Costimulatory molecules play important roles in T cell-mediated immune responses and the maintenance of T cell tolerance. Blocking costimulatory pathways can alter T cell responses and prolong graft survival. Better understanding of the roles of costimulatory molecules has facilitated the use of costimulatory blockade to effectively induce immune tolerance in animal transplantation models. In this article, we review the state of the art in costimulatory pathway blockade for the induction of immune tolerance in transplantation and its potential application prospects for liver transplantation.


2020 ◽  
Author(s):  
Zahra Sheikhalipour ◽  
Touraj Asvadi kermani ◽  
Farzad Kakaei ◽  
Azizeh Farshbaf Khalili ◽  
Leila Vahedi

Abstract Background: Following the pandemic of COVID-19 and the increased COVID-19 risk in transplant patient receptions, the authors assessed the prevalence, clinical course, and the outcome of the COVID-19 infection among liver transplant receptions. Methods: By designing and the use of researcher made questionnaire and the use of medical services, liver transplantation recipients under our center surveyed in terms of COVID-19 infection.Results: Seven patients infected with COVID-19 were identified from 265 liver transplantation recipients. The majority of patients were male and had COVID-19 despite being in-home quarantine. All patients received immunosuppressive drugs during infection with COVID-19 with no change in the routine immunosuppressive therapy. Among the identified patients, 5 recovered and 2 died. One of the dead patients, in addition to having a liver transplant, suffered brain cancer with metastasis to the lungs. Conclusion: It seems that the in liver transplants infected with COVID-19, the immunosuppressive drugs causes mild to moderate illness, and even recover from the disease.However, more evidence is needed to prove this hypothesis. It is also recommended that transplant recipients should be warned about personal hygiene and closely be monitored by organ transplant centers.


2013 ◽  
Vol 51 (01) ◽  
Author(s):  
A Gronert ◽  
P Fytili ◽  
V Schlaphoff ◽  
MP Manns ◽  
M Cornberg ◽  
...  

Hepatology ◽  
2020 ◽  
Vol 71 (4) ◽  
pp. 1508-1510 ◽  
Author(s):  
Edoardo Poli ◽  
Ilias Kounis ◽  
Catherine Guettier ◽  
Céline Verstuyft ◽  
Audrey Coilly ◽  
...  

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