Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes

Hepatology ◽  
2020 ◽  
Author(s):  
Daryl T.Y. Lau ◽  
Lilia Ganova‐Raeva ◽  
Junyao Wang ◽  
Douglas Mogul ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Young Age ◽  
Basal Core Promoter ◽  
Hbv Genotypes ◽  
B Virus ◽  
Hbv Variants

scholarly journals Genotyping Hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in hbv star

2006 ◽  
Vol 87 (6) ◽  
pp. 1459-1464 ◽  
Author(s):  
Richard Myers ◽  
Caroline Clark ◽  
Arshad Khan ◽  
Paul Kellam ◽  
Richard Tedder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Full Length ◽  
Basal Core Promoter ◽  
Hbv Genotype ◽  
Promoter Sequences ◽  
Hbv Genotypes ◽  
Scoring Matrices ◽  
B Virus

Hepatitis B virus (HBV) genomes have been classified into eight genotypes based on phylogenetic analysis of sequence variation. Identifying and tracking the movement of HBV genotypes is important in terms of both monitoring infection rates and predicting disease and treatment. An HBV genotyping tool has been developed that compares query sequences with position-specific scoring matrices representing the eight HBV genotypes. This tool (hbv star) is rapid, robust and accurate and assigns genotype based on a statistically defined scoring model. hbv star confidently assigned 90 % of 590 full-length HBV genomes to an HBV genotype (Z score >2.0). Thirty-two of the residual 48 sequences were identified as non-human primate viruses and 16 sequences were identified as recombinant or putative recombinants. Receiver-Operated Characteristic (ROC) analysis was used to compare the accuracy of genotype prediction using basal core promoter sequences and surface and core genes with the accuracy achieved by using full-length sequences. A web interface to hbv star is available at http://www.vgb.ucl.ac.uk/starn.shtml.

scholarly journals Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma

2011 ◽  
Vol 2 (3) ◽  
pp. 129
Author(s):  
Camillo Porta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
National Cancer Institute ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Common Variants ◽  
Virus Genotype ◽  
Hbv Genotypes ◽  
B Virus

In the August issue of the authoritative Journal of the National Cancer Institute, a research group from Taiwan reported the results of a huge study aimed at assessing a possible association between Hepatitis B virus (HBV) genotypes and common variants in the precore and basal core promoter (BP) regions and the risk of hepatocellular carcinoma (HCC)...

scholarly journals Global Occurrence of Clinically Relevant Hepatitis B Virus Variants as Found by Analysis of Publicly Available Sequencing Data

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1344 ◽  
Author(s):  
Stoyan Velkov ◽  
Ulrike Protzer ◽  
Thomas Michler
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Diagnostic Tests ◽  
Core Promoter ◽  
Hbv Infection ◽  
Basal Core Promoter ◽  
Genotype Distribution ◽  
B Virus ◽  
Hbv Variants ◽  
Geographical Locations

Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/pre-core region, or reverse transcriptase. However, a comprehensive overview of the distribution of HBV variants between HBV genotypes or different geographical locations is lacking. To address this, we performed an in silico analysis of publicly available HBV full-length genome sequences. We found that not only the serotype frequency but also the majority of clinically relevant mutations are primarily associated with specific genotypes. Distinct mutations enriched in certain world regions are not explained by the local genotype distribution. Two HBV variants previously identified to confer resistance to the nucleotide analogue tenofovir in vitro were not identified, questioning their translational relevance. In summary, our work elucidates the differences in the clinical manifestation of HBV infection observed between genotypes and geographical locations and furthermore helps identify suitable diagnostic tests and therapies.

scholarly journals Prevalence of Hepatitis B Virus Subgenotypes and Basal Core Promoter, Precore Variants in Patients with Acute Hepatitis B in Central Vietnam

Intervirology ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Tran Xuan Chuong ◽  
Yasushi Takeda ◽  
Masatoshi Ishigami ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Central Vietnam ◽  
B Virus ◽  
Acute Hepatitis B
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