C24‐Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation

Hepatology ◽  
2020 ◽  
Author(s):  
Yonglong Zhang ◽  
Hui Wang ◽  
Tao Chen ◽  
Haolu Wang ◽  
Xiaowen Liang ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Cancer Progression ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Signaling Activation

scholarly journals Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung

2010 ◽  
Vol 17 (4) ◽  
pp. 977-987 ◽  
Author(s):  
Luisella Righi ◽  
Marco Volante ◽  
Ida Rapa ◽  
Veronica Tavaglione ◽  
Frediano Inzani ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Differential Sensitivity ◽  
Initiation Factor ◽  
Target Of Rapamycin ◽  
Low Grade ◽  
Mtor Inhibition ◽  
Signaling Activation ◽  
Activation Status

Among alternative therapeutic strategies in clinically aggressive neuroendocrine tumors (NETs) of the lung, promising results have been obtained in experimental clinical trials with mammalian target of rapamycin (mTOR) inhibitors, though in the absence of a proven mTOR signaling activation status. This study analyzed the expression of phosphorylated mTOR (p-mTOR) and its major targets, the ribosomal p70S6-kinase (S6K) and the eukaryotic initiation factor 4E-binding protein 1 (4EBP1) in a large series of 218 surgically resected, malignant lung NETs, including 24 metastasizing typical carcinoids, 73 atypical carcinoids, 60 large cell neuroendocrine carcinomas (LCNECs), and 61 small cell carcinomas (SCLCs). By immunohistochemistry, low-to-intermediate-grade tumors as compared with high-grade tumors showed higher levels of p-mTOR and phosphorylated S6K (p-S6K) (P<0.001), at variance with phosphorylated 4EBP1 (p-4EBP1), which was mainly expressed in LCNECs and SCLCs (P<0.001). The activated status of mTOR pathway was proved by the strong correlation of p-mTOR with p-S6K and somatostatin receptor(s). Western blot analysis of NET tumor samples confirmed such findings, and differential sensitivity to mTOR inhibition according to mTOR pathway activation characteristics was determined in two lung carcinoid cell lines in vitro. None of the investigated molecules had an impact on survival. However, in low-grade tumors, low p-mTOR expression correlated with lymph node metastases (P=0.016), recurrent disease, and survival (P=0.005). In conclusion, these data demonstrate a differential mTOR activation status in the spectrum of pulmonary NETs, possibly suggesting that mTOR pathway profiling might play a predictive role in candidate patients for mTOR-targeted therapies.

Limited Significance of Activated Akt-Mammalian Target of Rapamycin Signaling Pathway in Prostate Cancer Progression

2014 ◽  
Vol 93 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Young Hwii Ko ◽  
Hideaki Miyake ◽  
Hosny M. Behnsawy ◽  
Jun Cheon ◽  
Masato Fujisawa
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Prostate Cancer Progression

scholarly journals Metastatic role of mammalian target of rapamycin signaling activation by chemoradiotherapy in advanced rectal cancer

2020 ◽  
Vol 111 (4) ◽  
pp. 1291-1302
Author(s):  
Hiroshi Shiratori ◽  
Kazushige Kawai ◽  
Masamichi Okada ◽  
Hiroaki Nozawa ◽  
Keisuke Hata ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Advanced Rectal Cancer ◽  
Target Of Rapamycin ◽  
Signaling Activation

Mammalian target of rapamycin signaling activation patterns in pancreatic neuroendocrine tumors

2013 ◽  
Vol 21 (4) ◽  
pp. 288-295 ◽  
Author(s):  
Yoko Komori ◽  
Kazuhiro Yada ◽  
Masayuki Ohta ◽  
Hiroki Uchida ◽  
Yukio Iwashita ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Pancreatic Neuroendocrine Tumors ◽  
Activation Patterns ◽  
Signaling Activation

scholarly journals Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

2013 ◽  
Vol 289 (7) ◽  
pp. 4145-4160 ◽  
Author(s):  
Anindita Das ◽  
David Durrant ◽  
Saisudha Koka ◽  
Fadi N. Salloum ◽  
Lei Xi ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Diabetic Mice ◽  
Mtor Inhibition ◽  
Type 2 Diabetic

scholarly journals ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation

2021 ◽  
Vol 12 (7) ◽  
pp. 1926-1935
Author(s):  
Xudong Zhang ◽  
Zhijun Kong ◽  
Xiaoliang Xu ◽  
Xiao Yun ◽  
Jiadeng Chao ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Cancer Progression ◽  
Mapk Signaling ◽  
Signaling Activation
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