The Patatin‐Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability

Hepatology ◽  
2020 ◽  
Vol 72 (5) ◽  
pp. 1569-1585
Author(s):  
Xiuyun Wang ◽  
Min Guo ◽  
Qian Wang ◽  
Qingjie Wang ◽  
Shasha Zuo ◽  
...  
Keyword(s):  
Vldl Secretion

4P-1016 NA2003: as a novel VLDL-secretion inhibitor

2003 ◽  
Vol 4 (2) ◽  
pp. 297-298
Author(s):  
M. Shiotani ◽  
S. Suzuki ◽  
Y. Nakatani ◽  
F. Itoh ◽  
T. Kurosawa ◽  
...  
Keyword(s):  
Vldl Secretion

scholarly journals Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2

2018 ◽  
Vol 60 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Zehra Irshad ◽  
Nikola Chmel ◽  
Raghu Adya ◽  
Victor A. Zammit
Keyword(s):  
Particle Size ◽  
Particle Number ◽  
Vldl Secretion

scholarly journals The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas

1992 ◽  
Vol 284 (2) ◽  
pp. 457-462 ◽  
Author(s):  
D Wiggins ◽  
G F Gibbons
Keyword(s):  
Fatty Acids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Intracellular Pool ◽  
Hepatocyte Cultures ◽  
Vldl Secretion ◽  
Vldl Assembly ◽  
Hepatic Triacylglycerol

In hepatocyte cultures maintained in the absence of extracellular fatty acids, at least 70% of the secreted very-low-density lipoprotein (VLDL) triacylglycerol was derived via lipolysis of intracellular triacylglycerol. This proportion was unchanged when the cells were exposed for 24 h to insulin or glucagon, hormones which decreased the overall secretion of intracellular triacylglycerol, or to chloroquine or tolbutamide, agents which inhibit lysosomal lipolysis. The rate of intracellular lipolysis was 2-3-fold greater than that required to maintain the observed rate of triacylglycerol secretion. Most of the fatty acids released were returned to the intracellular pool. Neither insulin nor glucagon had any significant effect on the overall lipolysis and re-esterification of intracellular triacylglycerol. In these cases a greater proportion of the released fatty acids re-entered the cellular pool, rather than being recruited for VLDL assembly. Tolbutamide inhibited intracellular lipolysis, but suppressed VLDL secretion to a greater extent. 3,5-Dimethylpyrazole did not affect lipolysis or VLDL secretion. The increased secretion of VLDL triacylglycerol observed after exposure of cells to insulin for 3 days was not accompanied by an increased rate of intracellular lipolysis. However, a larger proportion of the triacylglycerol secreted under these conditions may not have undergone prior lipolysis.

scholarly journals Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development

Theranostics ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 10874-10891
Author(s):  
Meng Yang ◽  
Qingli Liu ◽  
Tongling Huang ◽  
Wenjuan Tan ◽  
Linbing Qu ◽  
...  
Keyword(s):  
Receptor Alpha ◽  
Vldl Secretion ◽  
Sex Disparity ◽  
Estrogen Related Receptor

160 The effect of ACAT inhibition on VLDL secretion in rats fed a diet rich in fish-oil

1997 ◽  
Vol 25 (4) ◽  
pp. S688-S688 ◽  
Author(s):  
ANNA-MARIE BROWN ◽  
GEOFFREY F. GIBBONS
Keyword(s):  
Fish Oil ◽  
Vldl Secretion
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