scholarly journals Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis

Hepatology ◽  
2019 ◽  
Vol 71 (3) ◽  
pp. 972-989 ◽  
Author(s):  
Guido Carpino ◽  
Lorenzo Nevi ◽  
Diletta Overi ◽  
Vincenzo Cardinale ◽  
Wei‐Yu Lu ◽  
...  
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Tree Regeneration ◽  
Peribiliary Gland

scholarly journals Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yinka K. Davies ◽  
Cynthia J. Tsay ◽  
Dario V. Caccamo ◽  
Kathleen M. Cox ◽  
Ricardo O. Castillo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplantation ◽  
Primary Sclerosing Cholangitis ◽  
Orthotopic Liver Transplantation ◽  
Successful Treatment ◽  
Sclerosing Cholangitis ◽  
Bile Ducts ◽  
Biliary Tree ◽  
Oral Vancomycin ◽  
Inflammatory Bowel

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.

Primary Sclerosing Cholangitis

2015 ◽  
Author(s):  
Udayakumar Navaneethan
Keyword(s):  
Differential Diagnosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Biliary Cirrhosis ◽  
Extrahepatic Bile Ducts ◽  
Biliary Stasis ◽  
Inflammatory Bowel ◽  
Direct Peroral Cholangioscopy ◽  
Secondary Biliary Cirrhosis

Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree. The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications. This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis. Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC. Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC. This review contains 6 highly rendered figures, 5 tables, and 91 references. 

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis

2015 ◽  
Vol 63 (5) ◽  
pp. 1220-1228 ◽  
Author(s):  
Guido Carpino ◽  
Vincenzo Cardinale ◽  
Anastasia Renzi ◽  
Johannes R. Hov ◽  
Pasquale Bartolomeo Berloco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Peribiliary Glands ◽  
Tree Stem

Primary sclerosing cholangitis

2010 ◽  
pp. 2468-2473
Author(s):  
R.W. Chapman ◽  
K.D. Williamson
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Close Association ◽  
Biliary Tree ◽  
Cholestatic Liver Disease ◽  
Immune Mediated ◽  
Inflammatory Bowel

Case History—A 60 yr old woman, known to have long standing colitis, now presenting with abdominal pain and weight loss. Primary sclerosing cholangitis is a chronic cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The cause is unknown, but presumed to be immune mediated, and there is a very close association with inflammatory bowel disease, particularly ulcerative colitis....

scholarly journals Primary sclerosing cholangitis, the biliary tree, and ulcerative colitis.

Gut ◽  
1967 ◽  
Vol 8 (5) ◽  
pp. 435-448 ◽  
Author(s):  
M E Thorpe ◽  
P J Scheuer ◽  
S Sherlock
Keyword(s):  
Ulcerative Colitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree

scholarly journals Atypical presentation of autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome associated with hypereosinophilia: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Behzad Hatami ◽  
Hamide Rahmani Seraji ◽  
Mohaddese fallahi
Keyword(s):  
Magnetic Resonance ◽  
Autoimmune Hepatitis ◽  
Primary Sclerosing Cholangitis ◽  
Peripheral Blood ◽  
Sclerosing Cholangitis ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Biliary Tree ◽  
Overlap Syndrome ◽  
Elevated Liver Enzymes ◽  
Mitochondrial Antibody

Abstract Background Autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome is a form of autoimmune hepatitis with cholestatic features and is characterized by negative anti-mitochondrial antibody and cholangiographic changes on magnetic resonance cholangiopancreatography or endoscopic retrograde cholangiopancreatography. Peripheral blood hypereosinophilia in conjunction with autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome has not been reported yet. Here we present a case of autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome with hypereosinophilia. Case presentation A 33-year-old Iranian man with the fatigue, jaundice, elevated liver enzymes and alkaline phosphatase, and hypereosinophilia was referred to our hospital. Viral and autoimmune hepatitis were excluded, and secondary workups for hypereosinophilia were all negative. Magnetic resonance cholangiopancreatography showed beaded appearance of intra- and extrahepatic biliary tree, and liver biopsy revealed interface hepatitis. Therefore, the diagnosis of autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome was made, and prednisolone, azathioprine, and ursodeoxycholic acid was initiated. His jaundice and peripheral blood eosinophilia resolved after 2 weeks, and he became completely asymptomatic. Conclusion Eosinophils might contribute to the clinical presentation and disease complications.

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