scholarly journals Predicting Low Risk for Sustained Alcohol Use After Early Liver Transplant for Acute Alcoholic Hepatitis: The Sustained Alcohol Use Post–Liver Transplant Score

Hepatology ◽  
2019 ◽  
Vol 69 (4) ◽  
pp. 1477-1487 ◽  
Author(s):  
Brian P. Lee ◽  
Eric Vittinghoff ◽  
Christine Hsu ◽  
Hyosun Han ◽  
George Therapondos ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Liver Transplant ◽  
Alcoholic Hepatitis ◽  
Low Risk ◽  
Acute Alcoholic Hepatitis

Approaching Alcohol Use Disorder After Liver Transplantation for Acute Alcoholic Hepatitis

2021 ◽  
Author(s):  
Peng-Sheng Ting ◽  
Ahmet Gurakar ◽  
Jason Wheatley ◽  
Geetanjali Chander ◽  
Andrew M. Cameron ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcohol Use ◽  
Alcoholic Hepatitis ◽  
Alcohol Use Disorder ◽  
Acute Alcoholic Hepatitis

PS-206-Patterns and predictors of alcohol use after early liver transplant for alcoholic hepatitis

2019 ◽  
Vol 70 (1) ◽  
pp. e137
Author(s):  
Brian Lee ◽  
Mary Rinella ◽  
Gene Im ◽  
John Rice ◽  
Oren Fix ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Liver Transplant ◽  
Alcoholic Hepatitis

Histological Acute Alcoholic Hepatitis Does Not Impair Survival after Liver Transplant

2005 ◽  
Vol 100 ◽  
pp. S107
Author(s):  
Jennifer T. Wells ◽  
Adnan Said ◽  
Rashmi Agni ◽  
Parul Dureja ◽  
Alexandru I. Musat ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Alcoholic Hepatitis ◽  
Acute Alcoholic Hepatitis

scholarly journals CON: Liver Transplant Should Not Be Performed in Patients With Acute Alcoholic Hepatitis

2020 ◽  
Vol 16 (5) ◽  
pp. 182-185
Author(s):  
Parita Patel ◽  
Jennifer Wang ◽  
Anjana Pillai
Keyword(s):  
Liver Transplant ◽  
Alcoholic Hepatitis ◽  
Acute Alcoholic Hepatitis

scholarly journals Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story

2018 ◽  
Vol 24 (4) ◽  
pp. 358-366 ◽  
Author(s):  
Aiman Obed ◽  
Abdalla Bashir ◽  
Steffen Stern ◽  
Anwar Jarrad
Keyword(s):  
Liver Transplant ◽  
Alcoholic Hepatitis ◽  
Acute Alcoholic Hepatitis

Comparison of 1-Year Morbidity Following Liver Transplant for Acute Alcoholic Hepatitis Versus Alcoholic Cirrhosis

2021 ◽  
Vol 19 (5) ◽  
pp. 439-444
Author(s):  
Oya Andacoglu ◽  
Umut Özbek ◽  
Jack Liu ◽  
Carlos Figueredo ◽  
Kristina R. Chacko ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Alcoholic Hepatitis ◽  
Alcoholic Cirrhosis ◽  
Acute Alcoholic Hepatitis

scholarly journals Liver Transplantation for Alcoholic Liver Disease among Canadian Transplant Centres: A National Study

2013 ◽  
Vol 27 (11) ◽  
pp. 643-646 ◽  
Author(s):  
Natasha Chandok ◽  
Mohammed Aljawad ◽  
Angela White ◽  
Roberto Hernandez-Alejandro ◽  
Paul Marotta ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Liver Transplant ◽  
Alcoholic Liver Disease ◽  
Alcoholic Hepatitis ◽  
Graft Loss ◽  
National Policy ◽  
National Study ◽  
Acute Alcoholic Hepatitis ◽  
Number Of Patients

BACKGROUND/OBJECTIVE: Alcoholic liver disease (ALD) is a controversial yet established indication for liver transplantation (LT), and there is emerging evidence supporting a survival benefit in selected patients with severe acute alcoholic hepatitis. The aim of the present survey was to describe policies among Canadian transplant centres for patients with ALD.METHODS: A survey was distributed to the medical directors of all seven liver transplant centres in Canada.RESULTS: All seven liver transplant programs in Canada participated in the survey. Every centre requires patients to have a minimum of six months of abstinence from alcohol before listing for LT. Completion of a rehabilitation program is only mandatory in one program; the remaining programs do not mandate this if patients have demonstrated prolonged abstinence, and sufficient insight and social supports. No program considers LT for patients with severe acute alcoholic hepatitis, although six of the seven programs are interested in exploring a national policy. Random alcohol checks for waitlisted patients are performed routinely on patients listed for ALD at only one centre; the remaining centres only perform checks if there is clinical suspicion. In the past five years, the mean (± SD) number of patients per centre with graft dysfunction from recidivism was 10±4.36; a mean of 2.5±4.36 patients per centre developed graft failure.CONCLUSIONS: With minor exceptions, LT policies for subjects with ALD are uniform across Canadian transplant programs. Presently, no centres perform LT for acute alcoholic hepatitis, although there is broad interest in exploring a national policy. Recidivism resulting in graft loss is a rare phenomenon.

scholarly journals An Assessment of the Psychosocial Evaluation for Early Liver Transplantation in Patients with Acute Alcoholic Hepatitis in the context of Alcohol Use Disorder, A Case Control Study

2021 ◽  
Author(s):  
Aryeh Dienstag ◽  
Penina Dienstag ◽  
Kanwal Mohan ◽  
Omar Mirza ◽  
Elizabeth Schubert ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcohol Use ◽  
Alcoholic Hepatitis ◽  
Alcohol Use Disorder ◽  
Case Control Study ◽  
Scoring Systems ◽  
Harmful Drinking ◽  
Alcohol Relapse ◽  
Acute Alcoholic Hepatitis ◽  
Control Study

Abstract Background Severe acute alcoholic hepatitis (AAH) has an excessive mortality rate. As a result, many centers, including our own, have allowed transplant listing patients for transplantation prior to achievement of 6-months sobriety. Concurrently, scoring systems have been proposed to identify patients with alcohol use disorder (AUD) predisposed to relapse after liver transplantation. These scoring systems target patients with a minimal period of sobriety. Methods We conducted a retrospective case control study of 11 patients who underwent early liver transplantation for AAH matched with 11 controls who were declined secondary to low insight into AUD. Blinded raters confirmed the severity of the DSM-5 diagnosis and scored the patients on a variety of structured psychometric scales used to predict alcohol relapse. These included the High Risk for Alcohol Relapse scale (HRAR), Stanford Integrated Psychosocial Assessment Tool (SIPAT), Alcohol Relapse Risk Assessment (ARRA), Hopkins Psychosocial Scale (HPSS), Michigan Alcoholism Prognosis Score (MAPS), Alcohol Use Disorders Identification Test -Consumption (AUDIT-C) and Sustained Alcohol Use Post-Liver Transplant (SALT) scales. All patients who underwent transplantation were followed for harmful and non-harmful drinking until the end of the study period. Results Mean psychometric scores of the transplanted cases were significantly different than the controls. Cases chosen for transplant had significantly favorable MAPS, HRAR, SIPAT, ARRA, and HPSS scores with cut-offs matching their prior research. The SALT and AUDIT-C scores were not predictive of our selection of patients for transplant. Despite expedited assessment and no significant period of sobriety, our case cohort had a 30% relapse to harmful drinking after an average of 6.6 years (5 to 8.5 years) of follow-up. Discussion Despite the expedited assessment and short to no period of sobriety, the patient cohort demonstrated a 30% relapse to harmful drinking, consistent with the reported 20-30% after liver transplantation for all forms of alcoholic liver disease. The average MAPS, HRAR, SIPAT, ARRA, and HPSS scores all corroborated our current stratification procedures, with lower risk mean scores found in the transplanted group. Conclusion The traditional psychosocial selection criteria for patients with alcoholic hepatitis at our institution is consistent with four of the five investigated scoring systems.

Sign in / Sign up

Export Citation Format

Share Document