scholarly journals Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis

Hepatology ◽  
2018 ◽  
Vol 68 (5) ◽  
pp. 1905-1921 ◽  
Author(s):  
Amy E. Taylor ◽  
Alexandra N. Carey ◽  
Ramesh Kudira ◽  
Celine S. Lages ◽  
Tiffany Shi ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Sclerosing Cholangitis ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Cell Responses

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

2011 ◽  
Vol 365 (22) ◽  
pp. 2067-2077 ◽  
Author(s):  
David Saadoun ◽  
Michelle Rosenzwajg ◽  
Florence Joly ◽  
Adrien Six ◽  
Fabrice Carrat ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Low Dose ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Cell Responses

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals Regulatory T-Cell–Mediated Attenuation of T-Cell Responses to the NY-ESO-1 ISCOMATRIX Vaccine in Patients with Advanced Malignant Melanoma

2009 ◽  
Vol 15 (6) ◽  
pp. 2166-2173 ◽  
Author(s):  
Theo Nicholaou ◽  
Lisa M. Ebert ◽  
Ian D. Davis ◽  
Grant A. McArthur ◽  
Heather Jackson ◽  
...  
Keyword(s):  
T Cell ◽  
Malignant Melanoma ◽  
Regulatory T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Advanced Malignant Melanoma

scholarly journals Bifidobacterium breve Attenuates Murine Dextran Sodium Sulfate-Induced Colitis and Increases Regulatory T Cell Responses

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95441 ◽  
Author(s):  
Bin Zheng ◽  
Jeroen van Bergenhenegouwen ◽  
Saskia Overbeek ◽  
Hendrik J. G. van de Kant ◽  
Johan Garssen ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Sodium Sulfate ◽  
T Cell Responses ◽  
Dextran Sodium Sulfate ◽  
Bifidobacterium Breve ◽  
Cell Responses

scholarly journals Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection

2010 ◽  
Vol 84 (20) ◽  
pp. 10923-10927 ◽  
Author(s):  
Michael Molloy ◽  
Weijun Zhang ◽  
Edward Usherwood
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
T Cell Response ◽  
Long Term Memory ◽  
Murine Gammaherpesvirus ◽  
Cell Responses ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

ABSTRACT Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8+ T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8+ T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8+ T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8+ T cell mononucleosis.

scholarly journals MHC-Independent Genetic Factors Control the Magnitude of CD4+ T Cell Responses to Amyloid-β Peptide in Mice through Regulatory T Cell-Mediated Inhibition

2011 ◽  
Vol 187 (9) ◽  
pp. 4492-4500 ◽  
Author(s):  
Cécile Toly-Ndour ◽  
Gabrielle Lui ◽  
Maria Manuel Nunes ◽  
Martine Bruley-Rosset ◽  
Pierre Aucouturier ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Genetic Factors ◽  
Amyloid Β ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Amyloid Β Peptide ◽  
Cell Responses
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