Balancing exercise-induced weight loss with protein caloric requirement remains a challenge in overweight patients with cirrhosis

Hepatology ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 1644-1645
Author(s):  
Amritpal Dhaliwal ◽  
Jenny Towey ◽  
Geoffrey Haydon ◽  
Ahmed M. Elsharkawy ◽  
Matthew J. Armstrong
2011 ◽  
Vol 35 (2) ◽  
pp. 204-205
Author(s):  
A.R. Josse ◽  
S.A. Atkinson ◽  
M.A. Tarnopolsky ◽  
H. Azizian ◽  
J.K.G. Kramer ◽  
...  

2007 ◽  
Vol 102 (2) ◽  
pp. 634-640 ◽  
Author(s):  
Edward P. Weiss ◽  
Susan B. Racette ◽  
Dennis T. Villareal ◽  
Luigi Fontana ◽  
Karen Steger-May ◽  
...  

Caloric restriction (CR) results in fat loss; however, it may also result in loss of muscle and thereby reduce strength and aerobic capacity (V̇o2 max). These effects may not occur with exercise-induced weight loss (EX) because of the anabolic effects of exercise on heart and skeletal muscle. We tested the hypothesis that CR reduces muscle size and strength and V̇o2 max, whereas EX preserves or improves these parameters. Healthy 50- to 60-yr-old men and women (body mass index of 23.5–29.9 kg/m2) were studied before and after 12 mo of weight loss by CR ( n = 18) or EX ( n = 16). Lean mass was assessed by dual-energy X-ray absorptiometry, thigh muscle volume by MRI, isometric and isokinetic knee flexor strength by dynamometry, and treadmill V̇o2 max by indirect calorimetry. Both interventions caused significant decreases in body weight (CR: −10.7 ± 1.4%, EX: −9.5 ± 1.5%) and lean mass (CR: −3.5 ± 0.7%, EX: −2.2 ± 0.8%), with no significant differences between groups. Significant decreases in thigh muscle volume (−6.9 ± 0.8%) and composite knee flexion strength (−7.2 ± 3%) occurred in the CR group only. Absolute V̇o2 max decreased significantly in the CR group (−6.8 ± 2.3%), whereas the EX group had significant increases in both absolute (+15.5 ± 2.4%) and relative (+28.3 ± 3.0%) V̇o2 max. These data provide evidence that muscle mass and absolute physical work capacity decrease in response to 12 mo of CR but not in response to a similar weight loss induced by exercise. These findings suggest that, during EX, the body adapts to maintain or even enhance physical performance capacity.


2011 ◽  
Vol 43 (4) ◽  
pp. 199-212 ◽  
Author(s):  
Scott A. Kelly ◽  
Derrick L. Nehrenberg ◽  
Kunjie Hua ◽  
Theodore Garland ◽  
Daniel Pomp

The regulation of body weight and composition is complex, simultaneously affected by genetic architecture, the environment, and their interactions. We sought to analyze the complex phenotypic relationships between voluntary exercise, food consumption, and changes in body weight and composition and simultaneously localize quantitative trait loci (QTL) controlling these traits. A large ( n = 815) murine advanced intercross line (G4) was created from a reciprocal cross between a high-running line and the inbred strain C57BL/6J. Body weight and composition (% fat, % lean) were measured at 4, 6, and 8 wk of age. After measurements at 8 wk of age, mice were given access to running wheels, during which food consumption was quantified and after which body weight and composition were assessed to evaluate exercise-induced changes. Phenotypic correlations indicated that the relationship between exercise and overall change in weight and adiposity depended on body composition before the initiation of exercise. Interval mapping revealed QTL for body weight, % fat, and % lean at 4, 6, and 8 wk of age. Furthermore, QTL were observed for food consumption and changes in weight, % fat, and % lean in response to short-term exercise. Here we provide some clarity for the relationship between weight loss, reduction in adiposity, food consumption, and exercise. Simultaneously, we reinforce the genetic basis for body weight and composition with some independent loci controlling growth at different ages. Finally, we present unique QTL providing insight regarding variation in weight loss and reduction in adiposity in response to exercise.


Obesity ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 544-551
Author(s):  
Guang Ren ◽  
Robert L. Bowers ◽  
Teayoun Kim ◽  
Felipe Araya‐Ramirez ◽  
A. Jack Mahurin ◽  
...  

2018 ◽  
Vol 50 (5S) ◽  
pp. 161
Author(s):  
Jolene Lim ◽  
Govindasamy Balasekaran ◽  
Melissa Mayo ◽  
Visvasuresh Victor Govindaswamy

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