scholarly journals B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury

Hepatology ◽  
2018 ◽  
Vol 67 (5) ◽  
pp. 1970-1985 ◽  
Author(s):  
Francesca Faggioli ◽  
Eleonora Palagano ◽  
Luca Di Tommaso ◽  
Matteo Donadon ◽  
Veronica Marrella ◽  
...  
Keyword(s):  
Liver Injury ◽  
B Lymphocytes ◽  
Mouse Liver

Protective effect ofAsteracantha longifoliaextract in mouse liver injury induced by carbon tetrachloride and paracetamol

2003 ◽  
Vol 55 (10) ◽  
pp. 1413-1418 ◽  
Author(s):  
R. P. Hewawasam ◽  
K. A. P. W. Jayatilaka ◽  
C. Pathirana ◽  
L. K. B. Mudduwa
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Mouse Liver

Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury

2006 ◽  
Vol 535 (1-3) ◽  
pp. 263-269 ◽  
Author(s):  
Yan Zhang ◽  
Hailing Li ◽  
Yuling Zhao ◽  
Zhonghong Gao
Keyword(s):  
Liver Injury ◽  
Iron Overload ◽  
Mouse Liver ◽  
Dietary Supplementation

scholarly journals Protective Role of Estrogen-induced miRNA-29 Expression in Carbon Tetrachloride-induced Mouse Liver Injury

2012 ◽  
Vol 287 (18) ◽  
pp. 14851-14862 ◽  
Author(s):  
Yaqin Zhang ◽  
Linping Wu ◽  
Yang Wang ◽  
Mingcao Zhang ◽  
Limin Li ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Mouse Liver ◽  
Protective Role

scholarly journals Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver

2020 ◽  
Vol 48 (5) ◽  
pp. 326-336 ◽  
Author(s):  
Yifan Bao ◽  
Pei Wang ◽  
Xueyan Shao ◽  
Junjie Zhu ◽  
Jingcheng Xiao ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Injury ◽  
Mouse Liver ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Age Dependent

scholarly journals Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

2014 ◽  
Vol 3 (6) ◽  
pp. 948-956 ◽  
Author(s):  
John P. Cassady ◽  
Ana C. D’Alessio ◽  
Sovan Sarkar ◽  
Vardhan S. Dani ◽  
Zi Peng Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
B Lymphocytes ◽  
Mouse Liver ◽  
Adult Mouse ◽  
Liver Cells ◽  
Direct Lineage Conversion ◽  
Adult Mouse Liver

scholarly journals Liver injury changed the biological characters of serum small extracellular vesicles and reprogramed hepatic macrophages in mice

2021 ◽  
Author(s):  
Xiufang Lv ◽  
Jing Li ◽  
Li He ◽  
Li Cheng ◽  
Min Zhao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Extracellular Vesicles ◽  
Liver Diseases ◽  
Human Liver ◽  
Mouse Liver ◽  
Liver Steatosis ◽  
Biological Significance ◽  
Circulating Mirnas ◽  
Hepatic Macrophages ◽  
Liver Macrophage

Abstract Background Serum small extracellular vesicles (sEVs) and their small RNA (sRNA) cargoes could be promising biomarkers for the diagnosis of liver injury. However, the dynamic changes of serum sEVs and their sRNA components during liver injury and the biological functions of these liver-injury-serum sEVs have not been well characterized. Methods To identify serum sEV biomarkers for liver injury, we established a carbon tetrachloride-induced mouse liver injury model to simulate acute liver injury (ALI), chronic liver injury (CLI) and recovery. Serum sEVs were obtained and characterized. Serum sEV sRNAs were profiled. Differentially expressed microRNAs (miRNA) were compared to mouse liver enriched miRNAs and previously reported circulating miRNAs that related to human liver diseases. The biological significance was evaluated by Ingenuity Pathway Analysis of altered sEV miRNAs, and conditional culture of ALI serum sEVs with primary hepatic macrophages. Results We found that both ALI and CLI changed the concentration and morphology of serum sEVs. The proportion of serum sEV miRNA increased upon liver injury, with the liver as the primary contributor. The altered serum sEV miRNAs based on mice's study were consistent with those human liver diseases-related circulating miRNAs. Serum sEV miRNA signatures for ALI and CLI, and a panel of miRNAs as common marker for liver injury, were established. The differential serum sEV miRNAs in ALI mainly contributed to liver steatosis and inflammation, while those in CLI primarily contributed to hepatocellular carcinoma and hyperplasia. ALI serum sEVs decreased both CD86 and CD206 expression in monocyte-derived macrophages, but increased CD206 expression in resident macrophages. Conclusion Serum sEVs in the different stages of liver injury carried different sRNA messages and contributed to diverse pathological processes. ALI serum sEVs might alleviate liver damage by depolarizing monocyte-derived macrophages and educating resident liver macrophage to M2 like cells.

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