Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome‐wide association study

Hepatology ◽  
2018 ◽  
Vol 67 (2) ◽  
pp. 651-661 ◽  
Author(s):  
Mei‐Hsuan Lee ◽  
Yu‐Han Huang ◽  
Hsuan‐Yu Chen ◽  
Seik‐Soon Khor ◽  
Ya‐Hsuan Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Genome Wide Association Study ◽  
Human Leukocyte ◽  
Genome Wide Association ◽  
Leukocyte Antigen ◽  
Genome Wide ◽  
A Genome ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes

scholarly journals Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1017-1029 ◽  
Author(s):  
Andri Rauch ◽  
Ian James ◽  
Katja Pfafferott ◽  
David Nolan ◽  
Paul Klenerman ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Immune Pressure ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes

A genome‐wide association study on low susceptibility to hepatitis C virus infection (GEHEP012 study)

2019 ◽  
Vol 39 (10) ◽  
pp. 1918-1926
Author(s):  
Luis M. Real ◽  
Marta Fernández‐Fuertes ◽  
María E. Sáez ◽  
Antonio Rivero‐Juárez ◽  
Mario Frías ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Hepatitis C Virus Infection ◽  
Genome Wide ◽  
A Genome

scholarly journals Novel chemoimmunotherapeutic strategy for hepatocellular carcinoma based on a genome-wide association study

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kaku Goto ◽  
Dorcas A. Annan ◽  
Tomoko Morita ◽  
Wenwen Li ◽  
Ryosuke Muroyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome

2022 ◽  
Author(s):  
Tomoko Horinouchi ◽  
Kandai Nozu ◽  
Kazumoto Iijima
Keyword(s):  
Nephrotic Syndrome ◽  
Genome Wide Association Study ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Genome Wide ◽  
A Genome ◽  
Immunological Mechanisms ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
Genetic Techniques

Abstract Idiopathic nephrotic syndrome is the most common childhood glomerular disease. Most forms of this syndrome respond to corticosteroids at standard doses and are, therefore, defined as steroid-sensitive nephrotic syndrome (SSNS). Immunological mechanisms and subsequent podocyte disorders play a pivotal role in SSNS and have been studied for years; however, the precise pathogenesis remains unclear. With recent advances in genetic techniques, an exhaustive hypothesis-free approach called a genome-wide association study (GWAS) has been conducted in various populations. GWASs in pediatric SSNS peaked in the human leukocyte antigen class II region in various populations. Additionally, an association of immune-related CALHM6/FAM26F, PARM1, BTNL2, and TNFSF15 genes, as well as NPHS1, which encodes nephrin expressed in podocytes, has been identified as a locus that achieves genome-wide significance in pediatric SSNS. However, the specific mechanism of SSNS development requires elucidation. This review describes an updated view of SSNS pathogenesis from immunological and genetic aspects, including interactions with infections or allergies, production of circulating factors, and an autoantibody hypothesis.

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