Critical role of CREBH‐mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells

Hepatology ◽  
2017 ◽  
Vol 66 (5) ◽  
pp. 1430-1443 ◽  
Author(s):  
Takeshi Chida ◽  
Masahiko Ito ◽  
Kenji Nakashima ◽  
Yumi Kanegae ◽  
Takuya Aoshima ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Critical Role ◽  
Stellate Cells ◽  
Hepatitis C Virus Infection ◽  
Transforming Growth Factor Β2

CRITICAL ROLE OF VAL/GLY86 HLA-DRB DIMORPHISM IN THE NEONATAL RESISTANCE OR SUSCEPTIBILITY TO MATERNAL HEPATITIS C VIRUS INFECTION

1997 ◽  
Vol 16 (10) ◽  
pp. 1001-1002 ◽  
Author(s):  
Miryam Martinetti ◽  
Ilaria Pacati ◽  
Cristina Daielli ◽  
Laura Salvaneschi ◽  
Anna Maccabruni
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Critical Role ◽  
Hepatitis C Virus Infection

Hepatic Stellate Cells and Fibrogenesis in Hepatitis C Virus Infection: An Ultrastructural Insight

2010 ◽  
Vol 34 (2) ◽  
pp. 62-67 ◽  
Author(s):  
Soheir S. Mansy ◽  
Nagwa A. ElKhafif ◽  
Ahmed S. AbelFatah ◽  
Hoda A. Yehia ◽  
Ibrahim Mostafa
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Hepatitis C Virus Infection

scholarly journals The Role of Hepatic Stellate Cells and Transforming Growth Factor-β1 in Cystic Fibrosis Liver Disease

2002 ◽  
Vol 160 (5) ◽  
pp. 1705-1715 ◽  
Author(s):  
Peter J. Lewindon ◽  
Tamara N. Pereira ◽  
Anita C. Hoskins ◽  
Kim R. Bridle ◽  
Richard M. Williamson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1

1046 ROLE OF ANGIOPOIETIN RECEPTOR TIE-2 IN THE INVASION OF HUMAN HEPATIC STELLATE CELLS INDUCED BY HEPATITIS C VIRUS

2011 ◽  
Vol 54 ◽  
pp. S415-S416
Author(s):  
S. Martín-Vílchez ◽  
Y. Rodríguez-Muñoz ◽  
R. López-Rodríguez ◽  
Á. Hernández-Bartolomé ◽  
F. Molina-Jiménez ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatic Stellate Cells ◽  
Stellate Cells

scholarly journals Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 113 ◽  
Author(s):  
Murali Ganesan ◽  
Larisa Poluektova ◽  
Chijioke Enweluzo ◽  
Kusum Kharbanda ◽  
Natalia Osna
Keyword(s):  
Lipid Peroxidation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatic Stellate Cells ◽  
Parenchymal Cell ◽  
Human Monocyte ◽  
Stellate Cells ◽  
Liver Inflammation ◽  
Parenchymal Cells

Hepatocyte apoptosis is a crucially important mechanism for liver disease pathogenesis, and the engulfment of apoptotic bodies (AB) by non-parenchymal cells serves as a leading mechanism of inflammation and fibrosis progression. Previously, we have shown that hepatitis C virus (HCV) and alcohol metabolites induce massive apoptosis in hepatocytes and the spread of HCV-infection to the neighboring uninfected cells. Here, we hypothesize that the capturing of AB by non-parenchymal cells, macrophages and hepatic stellate cells (HSC) changes their phenotype to promote inflammation and fibrosis. In this regard, we generated AB from Huh7.5CYP2E1 (RLW) cells also treated with an acetaldehyde-generating system (AGS) and incubated them with human monocyte-derived macrophages (MDMs) and HSC (LX2 cells). Activation of inflammasomes and pro-fibrotic markers has been tested by RT-PCR and linked to HCV expression and AGS-induced lipid peroxidation in RLW cells. After exposure to AB we observed activation of inflammasomes in MDMs, with a higher effect of AB HCV+, further enhanced by incubation of MDMs with ethanol. In HSC, activation of inflammasomes was modest; however, HCV and AGS exposure induced pro-fibrotic changes. We conclude that HCV as well as lipid peroxidation-adducted proteins packaged in AB may serve as a vehicle for delivery of parenchymal cell cargo to non-parenchymal cells to activate inflammasomes and pro-fibrotic genes and promote liver inflammation and fibrosis.

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