scholarly journals Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study

Hepatology ◽  
2017 ◽  
Vol 65 (3) ◽  
pp. 929-937 ◽  
Author(s):  
Gro Askgaard ◽  
David A. Leon ◽  
Mette S. Kjaer ◽  
Thomas Deleuran ◽  
Thomas A. Gerds ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Alcohol Problems ◽  
Alcoholic Liver Cirrhosis ◽  
Initial Hospital ◽  
Hospital Contact

scholarly journals Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis

2018 ◽  
Vol 47 (4) ◽  
pp. 417-419
Author(s):  
Gro Askgaard ◽  
Janne S. Tolstrup ◽  
Mette S. Kjær ◽  
David A. Leon
Keyword(s):  
Liver Cirrhosis ◽  
Alcohol Intoxication ◽  
Heavy Drinking ◽  
Alcohol Problems ◽  
Alcoholic Liver Cirrhosis ◽  
Preventive Interventions ◽  
Harmful Alcohol ◽  
Hospital Patients ◽  
Initial Hospital ◽  
Hospital Contact

Aims: Alcoholic liver cirrhosis is usually preceded by years of heavy drinking. We investigated whether the risk of alcoholic liver cirrhosis increases as the number of hospital contacts with alcohol problems goes up. Methods: This was a supplementary analysis on a nationwide register-based cohort study. All patients in Denmark with an initial hospital contact with alcohol problems (alcohol intoxication, harmful alcohol use or alcohol dependence) 1998–2002, free of liver disease, were followed for diagnosis of alcoholic liver cirrhosis. The number of subsequent hospital contacts with alcohol problems was estimated as a time-dependent variable for each patient. Results: In all, 36,044 hospital patients with an initial hospital contact with alcohol problems were included. These patients had 301,525 subsequent hospital contacts with alcohol problems. Risk of alcoholic liver cirrhosis increased ( p < 0.0001) with number of alcohol hospital contacts in both men and women for up to nine contacts. Conclusions: The number of prior hospital contacts with alcohol problems might provide clinicians with a helpful metric in deciding whether to offer preventive interventions for alcoholic liver cirrhosis.

Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study

2015 ◽  
Vol 62 (5) ◽  
pp. 1061-1067 ◽  
Author(s):  
Gro Askgaard ◽  
Morten Grønbæk ◽  
Mette S. Kjær ◽  
Anne Tjønneland ◽  
Janne S. Tolstrup
Keyword(s):  
Liver Cirrhosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Alcohol Drinking ◽  
Prospective Cohort ◽  
Drinking Pattern ◽  
Alcoholic Liver Cirrhosis

scholarly journals Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: A prospective cohort study

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207162 ◽  
Author(s):  
Alica Kubesch ◽  
Leonie Quenstedt ◽  
Maged Saleh ◽  
Sabrina Rüschenbaum ◽  
Katharina Schwarzkopf ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Cohort Study ◽  
Vitamin D Deficiency ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hepatic Decompensation

scholarly journals Management of suspected paediatric meningitis: a multicentre prospective cohort study

2018 ◽  
Vol 103 (12) ◽  
pp. 1114-1118 ◽  
Author(s):  
Roshan Ramasamy ◽  
Louise Willis ◽  
Seilesh Kadambari ◽  
Dominic F Kelly ◽  
Paul T Heath ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospital Stay ◽  
Antibiotic Treatment ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Medical Professional ◽  
Antibiotic Administration ◽  
Medical Assessment ◽  
Hospital Records ◽  
Initial Hospital

ObjectiveTo quantify delays during management of children with suspected meningitis.DesignMulticentre prospective cohort study.SettingThree UK tertiary paediatric centres; June 2011–June 2012Patients388 children aged <16 years hospitalised with suspected meningitis or undergoing lumbar puncture (LP) during sepsis evaluation.Main outcome measuresTime of prehospital and in-hospital assessments, LP, antibiotic treatment and discharge; types of prehospital medical assessment and microbiological results. Data collected from hospital records and parental interview.Results220/388 (57%) children were seen by a medical professional prehospitalisation (143 by a general practitioner). Median times from initial hospital assessment to LP and antibiotic administration were 4.8 hours and 3.1 hours, respectively; 62% of children had their LP after antibiotic treatment. Median time to LP was shorter for children aged <3 months (3.0 hours) than those aged 3–23 months (6.2 hours, P<0.001) or age ≥2 years (20.3 hours, P<0.001). In meningitis of unknown cause, cerebrospinal fluid (CSF) PCR was performed for meningococcus in 7%, pneumococcus in 10% and enterovirus in 76%. When no pathogen was identified, hospital stay was longer if LP was performed after antibiotics (median 12.5 days vs 5.0 days, P=0.037).ConclusionsMost children had LP after antibiotics were administered, reducing yield from CSF culture, and PCRs were underused despite national recommendations. These deficiencies reduce the ability to exclude bacterial meningitis, increasing unnecessary hospital stay and antibiotic treatment.

scholarly journals Invasive aspergillosis in patients with underlying liver cirrhosis: a prospective cohort study

2017 ◽  
Vol 55 (8) ◽  
pp. 803-812 ◽  
Author(s):  
Juergen Prattes ◽  
Martin Hoenigl ◽  
Robert Krause ◽  
Walter Buzina ◽  
Thomas Valentin ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Cohort Study ◽  
Invasive Aspergillosis ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Intestinal permeability and complications in liver cirrhosis: A prospective cohort study

2012 ◽  
Vol 43 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Jaya Benjamin ◽  
Vikas Singla ◽  
Indu Arora ◽  
Seema Sood ◽  
Yogendra Kumar Joshi
Keyword(s):  
Liver Cirrhosis ◽  
Cohort Study ◽  
Intestinal Permeability ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Parental Alcohol Problems, Parental Divorce, and Type 2 Diabetes in Adulthood: A Longitudinal Prospective Cohort Study in Middle-Aged Men

2020 ◽  
Vol 82 (9) ◽  
pp. 817-822
Author(s):  
Subina Upadhyaya ◽  
Tommi Tolmunen ◽  
Antti-Pekka Elomaa ◽  
Aleksi Ruohomäki ◽  
Siiri-Liisi Kraav ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Parental Divorce ◽  
Alcohol Problems ◽  
Middle Aged ◽  
Parental Alcohol
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