Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study

Hepatology ◽  
2016 ◽  
Vol 64 (6) ◽  
pp. 2028-2037 ◽  
Author(s):  
Amalia Gastaldelli ◽  
Melania Gaggini ◽  
Giuseppe Daniele ◽  
Demetrio Ciociaro ◽  
Eugenio Cersosimo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Positron Emission Tomography ◽  
Adipose Tissue ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Dynamic Positron Emission Tomography ◽  
Positron Emission

scholarly journals Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study

2018 ◽  
Vol 178 (5) ◽  
pp. 523-531 ◽  
Author(s):  
Miikka-Juhani Honka ◽  
Aino Latva-Rasku ◽  
Marco Bucci ◽  
Kirsi A Virtanen ◽  
Jarna C Hannukainen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Positron Emission Tomography ◽  
Adipose Tissue ◽  
Glucose Uptake ◽  
Principal Component ◽  
Emission Tomography ◽  
Study Cohort ◽  
Tissue Specific ◽  
Positron Emission

Objective Insulin resistance is reflected by the rates of reduced glucose uptake (GU) into the key insulin-sensitive tissues, skeletal muscle, liver and adipose tissue. It is unclear whether insulin resistance occurs simultaneously in all these tissues or whether insulin resistance is tissue specific. Design and methods We measured GU in skeletal muscle, adipose tissue and liver and endogenous glucose production (EGP), in a single session using 18F-fluorodeoxyglucose with positron emission tomography (PET) and euglycemic–hyperinsulinemic clamp. The study population consisted of 326 subjects without diabetes from the CMgene study cohort. Results Skeletal muscle GU less than 33 µmol/kg tissue/min and subcutaneous adipose tissue GU less than 11.5 µmol/kg tissue/min characterized insulin-resistant individuals. Men had considerably worse insulin suppression of EGP compared to women. By using principal component analysis (PCA), BMI inversely and skeletal muscle, adipose tissue and liver GU positively loaded on same principal component explaining one-third of the variation in these measures. The results were largely similar when liver GU was replaced by EGP in PCA. Liver GU and EGP were positively associated with aging. Conclusions We have provided threshold values, which can be used to identify tissue-specific insulin resistance. In addition, we found that insulin resistance measured by GU was only partially similar across all insulin-sensitive tissues studied, skeletal muscle, adipose tissue and liver and was affected by obesity, aging and gender.

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