scholarly journals GNPAT p.D519G variant and iron metabolism during oral iron tolerance test

Hepatology ◽  
2016 ◽  
Vol 65 (1) ◽  
pp. 384-385 ◽  
Author(s):  
Raffaela Rametta ◽  
Paola Dongiovanni ◽  
Silvia Fargion ◽  
Luca Valenti
Keyword(s):  
Iron Metabolism ◽  
Tolerance Test ◽  
Oral Iron ◽  
Iron Tolerance

scholarly journals Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hafid O. Al-Hassi ◽  
Oliver Ng ◽  
Rayko Evstatiev ◽  
Manel Mangalika ◽  
Natalie Worton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Iron Transport ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Loading ◽  
Deficiency Anaemia ◽  
Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

Oral Iron Treatment Has a Positive Effect on Iron Metabolism in Elite Soccer Players

2010 ◽  
Vol 142 (3) ◽  
pp. 398-406 ◽  
Author(s):  
Jesús Villanueva ◽  
Marisol Soria ◽  
Carlos González-Haro ◽  
Laura Ezquerra ◽  
José L. Nieto ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Oral Iron ◽  
Soccer Players ◽  
Iron Treatment ◽  
Positive Effect

Blood Sugar Concentration after Glucose Tolerance Test and Simultaneous Iron Tolerance Test

Nature ◽  
1966 ◽  
Vol 212 (5066) ◽  
pp. 1050-1051
Author(s):  
G. BRÜSCHKE ◽  
H. HERRMANN ◽  
P. SCHMIDT ◽  
D. VOIGT
Keyword(s):  
Glucose Tolerance ◽  
Blood Sugar ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Sugar Concentration ◽  
Blood Sugar Concentration ◽  
Iron Tolerance

Small-dose iron tolerance test and body iron content in normal subjects

2009 ◽  
Vol 46 (3) ◽  
pp. 152-157 ◽  
Author(s):  
Attilia Costa ◽  
Lucio N. Liberato ◽  
Pietro Palestra ◽  
Giovanni Barosi
Keyword(s):  
Iron Content ◽  
Small Dose ◽  
Normal Subjects ◽  
Tolerance Test ◽  
Body Iron ◽  
Iron Tolerance

scholarly journals Elevated hepcidin, ferroportin associated with glucose metabolism disorder in midpregnancy

2020 ◽  
Author(s):  
Ziwen Ma ◽  
Yan Cheng ◽  
Qingying Zhang ◽  
Kui Wu ◽  
Tingting Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Iron Metabolism ◽  
Plasma Glucose ◽  
Tolerance Test ◽  
Control Group ◽  
Oral Glucose ◽  
Model Assessment ◽  
Metabolism Disorder ◽  
Glucose Metabolism Disorder

Abstract [Objective]: Hepcidin and ferroportin are major regulators of iron metabolism. Although many previous studies have shown that iron metabolism disorder may contribute to the pathogenesis of Type 2 diabetes mellitus (DM), few studies have investigated hepcidin and other iron metabolism parameters in women with gestational diabetes mellitus (GDM). The purpose of this study was to determine the relationship between hepcidin, ferroportin and GDM. [Methods]: A case-control study was conducted in 85 women with GDM and 85 women without GDM (controls) who received regular prenatal care at the Obstetrics and Gynecology Hospital of Fudan University from October 2015 to May 2016. Serum ferritin (SF), hepcidin (Hepc), ferroportin (FPN), and soluble transferrin receptor (sTfR), as well as other clinical parameters, were detected and analyzed in all groups. [Results]: The levels of fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) 1-h and 2-h plasma glucose, glycated hemoglobin (HbA1c), SF, Hepc, FPN and sTfR as well as homeostasis model assessment for insulin resistance (HOMA-IR) were significantly higher in the GDM group (P<0.05 for all). In the GDM group, FPN was positively correlated OGTT-1 h and OGTT-2 h In the control group, only sTfR was positively correlated with OGTT-1 h. There was no correlation between the iron metabolism indicators in both GDM and control group.[Conclusion]: Hepc, FPN sRfR and SF levels were higher in the GDM group. Elevated Hepc and FPN are associated with glucose metabolism disorder and may play an important role in GDM.

scholarly journals The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption – a stable iron isotope study in Taiwanese women

Haematologica ◽  
2020 ◽  
pp. 0-0
Author(s):  
Simone Buerkli ◽  
Sung-Nan Pei ◽  
Shu-Chen Hsiao ◽  
Chien-Te Lee ◽  
Christophe Zeder ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Serum Iron ◽  
Iron Absorption ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Oral Iron ◽  
Iron Isotope ◽  
Genome Wide ◽  
Taiwanese Women ◽  
Isotope Study

Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe as FeSO4 on alternate days. Fractional iron absorption was measured by erythrocyte incorporation of the tracers 14 days after administration. Compared to the CC variant, in the TT variant serum iron and transferrin saturation were lower (P=0.001; P

The iron tolerance test measurement of absorption and utilization of a therapeutic dose of iron

1966 ◽  
Vol 13 (6) ◽  
pp. 701-707 ◽  
Author(s):  
W.F. Wiltink ◽  
H.J. Ybema ◽  
B. Leijnse ◽  
J. Gerbrandy
Keyword(s):  
Therapeutic Dose ◽  
Tolerance Test ◽  
Test Measurement ◽  
Iron Tolerance
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