scholarly journals A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients

Hepatology ◽  
2016 ◽  
Vol 64 (5) ◽  
pp. 1462-1472 ◽  
Author(s):  
Damien Ulveling ◽  
Sigrid Le Clerc ◽  
Aurélie Cobat ◽  
Taoufik Labib ◽  
Josselin Noirel ◽  
...  
Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1056-1063 ◽  
Author(s):  
Juan Macías ◽  
Juan Berenguer ◽  
Miguel A. Japón ◽  
José A. Girón ◽  
Antonio Rivero ◽  
...  

2013 ◽  
Vol 50 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Cristiane Valle TOVO ◽  
Smile Calisto da Costa BECKER ◽  
Paulo Roberto Lerias de ALMEIDA ◽  
Bruno GALPERIM ◽  
Silvia CHAVES

ContextThe progression of liver fibrosis in patients coinfected by hepatitis C virus and human immunodeficiency virus (HCV/HIV) has been increasingly studied in the past decade. Studies made before the highly active antiretroviral therapy suggest that HIV can change the natural history of the HCV infection, leading to a faster progression of the liver fibrosis.ObjectiveTo evaluate and compare the fibrosis progression in two groups of patients (HCV/HIV coinfected and HCV monoinfected)MethodsSeventy patients HCV monoinfected and 26 patients HCV/HIV coinfected who had not undertaken HCV treatment and were submitted to serial percutaneous liver biopsies were retrospectively evaluated. There was no difference in the fibrosis progression between the two groups.ConclusionThe fibrosis grade evolution was not worse in the coinfected patients. The immunosuppression absence and the shortest time period between the biopsies in the coinfected group are possible explanations.


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