scholarly journals Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

Hepatology ◽  
2016 ◽  
Vol 64 (2) ◽  
pp. 425-438 ◽  
Author(s):  
Qi Gong ◽  
Zhimin Hu ◽  
Feifei Zhang ◽  
Aoyuan Cui ◽  
Xin Chen ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Hepatic Insulin Sensitivity

scholarly journals Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children

2019 ◽  
Vol 3 (4) ◽  
pp. 825-837 ◽  
Author(s):  
Satu Seppä ◽  
Sirpa Tenhola ◽  
Raimo Voutilainen
Keyword(s):  
Insulin Sensitivity ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Gestational Age ◽  
Multivariate Regression ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Regression Analyses

Abstract Context Among cytokines, fibroblast growth factor 21 (FGF21), adiponectin (Adn), and irisin have been considered potential biomarkers for insulin sensitivity (IS). Objective We evaluated whether serum FGF21, Adn, and irisin associate with markers of IS and serum lipids in 12-year-old children. Design, Participants, and Main Outcome Measures This cohort study included 192 12-year-old children (109 girls). Seventy-eight of them had been born appropriate for gestational age (AGA), 70 small for gestational age (SGA), and 44 from preeclamptic pregnancies (PREs) as AGA. Fasting serum FGF21, Adn, irisin, lipids, inflammatory markers, and IS markers were measured. Quantitative insulin sensitivity check index (QUICKI) was calculated. Results The means of serum FGF21, high molecular weight (HMW) Adn, and irisin did not differ between the sexes or between the SGA, AGA, and PRE children. In the whole study population, FGF21 associated positively with irisin and uric acid and negatively with leptin and high-density lipoprotein cholesterol (HDL-C). HMW Adn associated positively with total Adn, HDL-C, leptin, and SHBG. Apart from FGF21, irisin associated positively with insulin, high-sensitivity C-reactive protein, γ-glutamyltransferase, and triglycerides, and negatively with QUICKI, SHBG, and IGF binding protein-1. In multivariate regression analyses, irisin predicted lower IS and HMW Adn predicted higher HDL-C body mass index-independently, whereas FGF21 had no independent contribution to IS or lipid variables. Conclusion In 12-year-old children, serum irisin was associated with markers reflecting reduced IS. HMW Adn predicted HDL-C, whereas FGF21 did not contribute to IS or lipid parameters in multivariate regression analyses.

Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats

2016 ◽  
Vol 35 (2) ◽  
pp. 142-149 ◽  
Author(s):  
Narattaphol Charoenphandhu ◽  
Panan Suntornsaratoon ◽  
Nateetip Krishnamra ◽  
Piangkwan Sa-nguanmoo ◽  
Pongpun Tanajak ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Bone Microstructure ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Insulin Resistant

scholarly journals Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

Diabetes ◽  
2010 ◽  
Vol 59 (7) ◽  
pp. 1817-1824 ◽  
Author(s):  
D. A. Sarruf ◽  
J. P. Thaler ◽  
G. J. Morton ◽  
J. German ◽  
J. D. Fischer ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Growth Factor ◽  
Energy Expenditure ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Obese Rats ◽  
The Brain

scholarly journals Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

Endocrinology ◽  
2009 ◽  
Vol 150 (9) ◽  
pp. 4084-4093 ◽  
Author(s):  
Eric D. Berglund ◽  
Candice Y. Li ◽  
Holly A. Bina ◽  
Sara E. Lynes ◽  
M. Dodson Michael ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Growth Factor ◽  
Glycemic Control ◽  
Fibroblast Growth Factor ◽  
Glucose Disposal ◽  
Daily Injection ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Glucose Flux ◽  
Hepatic Glucose

Abstract Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator shown to improve glycemic control. However, the molecular and functional mechanisms underlying FGF21-mediated improvements in glycemic control are not completely understood. We examined FGF21 effects on insulin sensitivity and glucose fluxes upon chronic (daily injection for 8 d) and acute (6 h infusion) administration in ob/+ and ob/ob mice. Results show that chronic FGF21 ameliorated fasting hyperglycemia in ob/ob mice via increased glucose disposal and improved hepatic insulin sensitivity. Acute FGF21 suppressed hepatic glucose production, increased liver glycogen, lowered glucagon, and improved glucose clearance in ob/+ mice. These effects were blunted in ob/ob mice. Neither chronic nor acute FGF21 altered skeletal muscle or adipose tissue glucose uptake in either genotype. In conclusion, FGF21 has potent glycemic effects caused by hepatic changes in glucose flux and improved insulin sensitivity. Thus, these studies define mechanisms underlying anti-hyperglycemic actions of FGF21 and support its therapeutic potential.

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