Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 534-545 ◽  
Author(s):  
Jessica Lo ◽  
Eunice Yuen Ting Lau ◽  
Rachel Hiu Ha Ching ◽  
Bowie Yik Ling Cheng ◽  
Mark Kin Fai Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma

Hepatology ◽  
2013 ◽  
Vol 58 (6) ◽  
pp. 1977-1991 ◽  
Author(s):  
Wen-Ping Xu ◽  
Min Yi ◽  
Qian-Qian Li ◽  
Wei-Ping Zhou ◽  
Wen-Ming Cong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Regulatory Circuit

scholarly journals Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 3721-3729 ◽  
Author(s):  
Meng Dong ◽  
Lin Miao ◽  
Fengmei Zhang ◽  
Shengshui Li ◽  
Jingzhi Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Human Hepatocellular Carcinoma ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Glutaminase 1

scholarly journals MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Hepatology ◽  
2013 ◽  
Vol 57 (5) ◽  
pp. 1919-1930 ◽  
Author(s):  
Lisheng Zhang ◽  
Lixin Yang ◽  
Xiyong Liu ◽  
Wei Chen ◽  
Lufen Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Hepatocellular Carcinoma with Osteoclast-Like Giant Cells: Report of the Seventh Case in the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Lorenzo Dioscoridi ◽  
Damiano Bisogni ◽  
Giancarlo Freschi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Wedge Resection ◽  
Liver Neoplasm ◽  
Giant Cells ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator ◽  
Upper Abdominal ◽  
The Right

Hepatocellular carcinoma with osteoclast-like giant cells is extremely rare, and only six cases have been previously reported. Its histogenesis is at the moment controversial. The authors report a case of hepatocellular carcinoma with osteoclast-like giant cells found in a 74-year-old woman. The patient came with a dull pain in the right upper abdominal quadrants due to a liver neoplasm described at CT scan. A wedge resection of the fifth hepatic segment with appendectomy, omentectomy, and debulking of the major peritoneal implants was performed. Histologically, the diagnosis of hepatocellular carcinoma with high grade differentiation associated with giant osteoclast-like cells was done without any evidence of hepatitis or cirrhosis in the surrounding hepatic parenchyma. Immunohistochemistry was positive for CD10 and CD68 and in situ hybridization revealed the expression of receptor activator of nuclear factor-kappa B (RANK) in the giant cells and receptor activator of nuclear factor-kappa B ligand (RANKL) in the tumor cells.

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