scholarly journals Sphingosine-1-phosphate receptor 2: A novel bile acid receptor and regulator of hepatic lipid metabolism?

Hepatology ◽  
2015 ◽  
Vol 61 (4) ◽  
pp. 1118-1120 ◽  
Author(s):  
John Y.L. Chiang
Keyword(s):  
Lipid Metabolism ◽  
Bile Acid ◽  
Hepatic Lipid Metabolism ◽  
Acid Receptor ◽  
Hepatic Lipid ◽  
Sphingosine 1 Phosphate ◽  
Bile Acid Receptor

scholarly journals Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism

2017 ◽  
Vol 3 (4) ◽  
pp. 176-183 ◽  
Author(s):  
Eric K. Kwong ◽  
Xiaojiaoyang Li ◽  
Phillip B. Hylemon ◽  
Huiping Zhou
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Sphingosine 1 Phosphate ◽  
Sphingosine Kinases

scholarly journals Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism

2015 ◽  
Vol 5 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Eric Kwong ◽  
Yunzhou Li ◽  
Phillip B. Hylemon ◽  
Huiping Zhou
Keyword(s):  
Lipid Metabolism ◽  
Bile Acids ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Sphingosine 1 Phosphate

scholarly journals Bile Acid Receptors in Cholangiocyte

2021 ◽  
Vol 26 (4) ◽  
pp. 254-259
Author(s):  
Jin Myung Park
Keyword(s):  
Bile Acid ◽  
Energy Metabolism ◽  
Inflammatory Response ◽  
Bile Acids ◽  
G Protein ◽  
Bile Flow ◽  
Acid Receptor ◽  
Sphingosine 1 Phosphate ◽  
Bile Acid Receptor ◽  
Bile Acid Receptors

Bile acids are known to play a role in helping the digestion of lipid and maintenance of the bile flow. However, since the first bile acid receptor was discovered in 1999, it has been found that various bile acid receptors are present. Bile acid receptors are involved in bile acid physiology, energy metabolism, and inflammatory response. G-protein bile acid-activated receptor 1 (GPBAR1) and Sphingosine-1-phosphate receptor 2 (S1PR2) are representative bile acid receptors in cholangiocyte. They are involved in proliferation and secretion of cholangiocyte, which seem to protect cholangiocyte from the toxicity of bile acids. GPBAR1 and S1PR2 are also associated with the progression of cholangiocarcinoma.

scholarly journals Circadian Rhythm Disruption Influenced Hepatic Lipid Metabolism, Gut Microbiota and Promoted Cholesterol Gallstone Formation in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Chuanqi He ◽  
Weiyi Shen ◽  
Chaobo Chen ◽  
Qihan Wang ◽  
Qifan Lu ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Lipid Metabolism ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Cholesterol Metabolism ◽  
Gallstone Formation ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Lithogenic Diet ◽  
Circadian Expression

BackgroundHepatic lipid metabolism regulates biliary composition and influences the formation of cholesterol gallstones. The genes Hmgcr and Cyp7a1, which encode key liver enzymes, are regulated by circadian rhythm-related transcription factors. We aimed to investigate the effect of circadian rhythm disruption on hepatic cholesterol and bile acid metabolism and the incidence of cholesterol stone formation.MethodsAdult male C57BL/6J mice were fed either a lithogenic diet (LD) only during the sleep phase (time-restricted lithogenic diet feeding, TRF) or an LD ad libitum (non-time-restricted lithogenic diet feeding, nTRF) for 4 weeks. Food consumption, body mass gain, and the incidence of gallstones were assessed. Circulating metabolic parameters, lipid accumulation in the liver, the circadian expression of hepatic clock and metabolic genes, and the gut microbiota were analyzed.ResultsTRF caused a dysregulation of the circadian rhythm in the mice, characterized by significant differences in the circadian expression patterns of clock-related genes. In TRF mice, the circadian rhythms in the expression of genes involved in bile acid and cholesterol metabolism were disrupted, as was the circadian rhythm of the gut microbiota. These changes were associated with high biliary cholesterol content, which promoted gallstone formation in the TRF mice.ConclusionDisordered circadian rhythm is associated with abnormal hepatic bile acid and cholesterol metabolism in mice, which promotes gallstone formation.

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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