scholarly journals Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

Hepatology ◽  
2015 ◽  
Vol 61 (2) ◽  
pp. 515-525 ◽  
Author(s):  
Silvia Sookoian ◽  
Gustavo O. Castaño ◽  
Romina Scian ◽  
Pablo Mallardi ◽  
Tomas Fernández Gianotti ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Vitamin D deficiency: prevalence and association with liver disease severity in pediatric nonalcoholic fatty liver disease

2019 ◽  
Vol 74 (3) ◽  
pp. 427-435 ◽  
Author(s):  
Toshifumi Yodoshi ◽  
Sarah Orkin ◽  
Ana Catalina Arce-Clachar ◽  
Kristin Bramlage ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

697 Novel Approach Reveals That Genetic Variation in/Near FXR/RXR Pathway Genes Predisposes to Nonalcoholic Fatty Liver Disease in Humans

2014 ◽  
Vol 146 (5) ◽  
pp. S-923
Author(s):  
Yindra Puentes ◽  
Laura M. Yerges-Armstrong ◽  
Corey C. Powell ◽  
Lawrence F. Bielak ◽  
Mary F. Feitosa ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Novel Approach

scholarly journals The gut-liver axis in nonalcoholic fatty liver disease: association of intestinal permeability with disease severity and treatment outcomes

2021 ◽  
Author(s):  
Yu-Pei Zhuang ◽  
Yi-Ting Zhang ◽  
Hao-Jie Zhong ◽  
Xing-Xiang He
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Disease Severity ◽  
Intestinal Permeability ◽  
Fatty Liver Disease ◽  
Diamine Oxidase ◽  
Nonalcoholic Fatty Liver ◽  
Metabolic Therapy ◽  
Attenuation Parameter

Objective To investigate the association between intestinal permeability and severity of nonalcoholic fatty liver disease (NAFLD), and the value of intestinal permeability in predicting the efficacy of metabolic therapy for NAFLD. Methods Disease severity was compared between patients with normal and elevated intestinal permeability; correlations between D-lactate and different NAFLD parameters were analyzed; and the effects of metabolic therapy on NAFLD patients with normal and elevated intestinal permeability were evaluated. Results A total of 190 patients with NAFLD were enrolled. NAFLD patients with elevated intestinal permeability had significantly higher levels of liver test parameters, liver ultrasonographic fat attenuation parameter, triglyceride, homeostasis model assessment of insulin resistance value and diamine oxidase (all P˂0.05) than NAFLD patients with normal intestinal permeability. Further, serum D-lactate levels were positively correlated with alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, total bilirubin, indirect bilirubin, fat attenuation parameter, triglyceride, and diamine oxidase (all P˂0.05). Moreover, NAFLD patients with elevated intestinal permeability showed less improvement in TG levels (P=0.014) after metabolic therapy. Conclusion Intestinal permeability correlates with the disease severity in patients with NAFLD. Moreover, intestinal permeability may have value for predicting the efficacy of metabolic therapy for NAFLD patients.

scholarly journals Glomerular Hyperfiltration Is Associated with Liver Disease Severity in Children with Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol 222 ◽  
pp. 127-133 ◽  
Author(s):  
Toshifumi Yodoshi ◽  
Ana Catalina Arce-Clachar ◽  
Qin Sun ◽  
Lin Fei ◽  
Kristin Bramlage ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Glomerular Hyperfiltration ◽  
Nonalcoholic Fatty Liver
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