scholarly journals HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection

Hepatology ◽  
2014 ◽  
Vol 60 (4) ◽  
pp. 1170-1179 ◽  
Author(s):  
Benjamin Israelow ◽  
Christopher M. Narbus ◽  
Marion Sourisseau ◽  
Matthew J. Evans
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Hepg2 Cells ◽  
Innate Immune ◽  
Hepatitis C Virus Infection ◽  
Interferon Lambda

scholarly journals ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell-mediated innate immune response in human hepatocytes

FEBS Open Bio ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 361-371 ◽  
Author(s):  
Hiromichi Dansako ◽  
Hirotaka Imai ◽  
Youki Ueda ◽  
Shinya Satoh ◽  
Takaji Wakita ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Innate Immune Response ◽  
Nk Cell ◽  
Human Hepatocytes ◽  
Innate Immune ◽  
Hepatitis C Virus Infection

scholarly journals The Hepatitis C Virus-Induced Membranous Web in Liver Tissue

Cells ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 191
Author(s):  
Emmanuelle Blanchard ◽  
Philippe Roingeard
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Innate Immune Response ◽  
Liver Tissue ◽  
Hepatoma Cell ◽  
Membrane Vesicles ◽  
Innate Immune ◽  
Host Cell Membrane

Host cell membrane rearrangements induced by the hepatitis C virus (HCV) have been exclusively studied in vitro. These studies have shown that HCV induces double-membrane vesicles (DMVs), which probably serve to separate replication sites from the cytoplasmic sensors of the innate immune response. We report for the first time the observation of HCV-induced membrane rearrangements in liver biopsy specimens from patients chronically infected with HCV. Unlike observations performed in vitro, the membranous web detected in liver tissue seems essentially made of clusters of single-membrane vesicles derived from the endoplasmic reticulum and close to lipid droplets. This suggests that the DMVs could be a hallmark of laboratory-adapted HCV strains, possibly due to their ability to achieve a high level of replication. Alternatively, the concealment of viral RNA in DMVs may be part of innate immune response mechanisms particularly developed in hepatoma cell lines cultured in vitro. In any case, this constitutes the first report showing the differences in the membranous web established by HCV in vitro and in vivo.

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