scholarly journals Identification of MicroRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression

Hepatology ◽  
2014 ◽  
Vol 60 (2) ◽  
pp. 598-609 ◽  
Author(s):  
Dong-liang Chen ◽  
Zhi-qiang Wang ◽  
Zhao-lei Zeng ◽  
Wen-jing Wu ◽  
Dong-sheng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Liver Metastasis ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Negative Regulator ◽  
Fibroblast Growth ◽  
Colorectal Cancer Liver Metastasis

Fibroblast Growth Factor Receptor-2 IIIc as a Novel Molecular Target in Colorectal Cancer

2013 ◽  
Vol 10 (1) ◽  
pp. 20-26
Author(s):  
Yoko Matsuda ◽  
Seiichi Shinji ◽  
Hisashi Yoshimura ◽  
Zenya Naito ◽  
Toshiyuki Ishiwata
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Molecular Target ◽  
Fibroblast Growth

Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer

Biomarkers ◽  
2014 ◽  
Vol 19 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Chen-Sheng Li ◽  
Shu-Xiang Zhang ◽  
Hong-Jun Liu ◽  
Yu-Long Shi ◽  
Le-Ping Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

scholarly journals Fibroblast Growth Factor Receptor 2: Expression, Roles, and Potential As a Novel Molecular Target for Colorectal Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yoko Matsuda ◽  
Junji Ueda ◽  
Toshiyuki Ishiwata
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cancer Progression ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Type Iv ◽  
Well Differentiated ◽  
Novel Target

The fibroblast growth factor receptor (FGFR) family consists of four members, named FGFR1, 2, 3, and 4. All 4 FGFRs and their ligands, fibroblast growth factors (FGFs), are expressed in colorectal cancer (CRC). Recent studies have shown that FGFR2 plays important roles in cancer progression; therefore, it is of great interest as a novel target for cancers. Expression of FGFR2 regulates migration, invasion, and growth in CRC. Expression of the FGFR2 isoform FGFR2 IIIb was associated with well-differentiated histological types, and its specific ligand, FGF7, enhanced angiogenesis and adhesion to type-IV collagen via FGFR2 IIIb in CRC. FGFR2 IIIc is detected in CRC, but its roles have not been well elucidated. Interactions between FGFR2 IIIb and IIIc and FGFs may play important roles in CRC via autocrine and/or paracrine signaling. Several kinds of molecular-targeting agents against FGFR2 have been developed; however, it is not clear how a cancer treatment can most effectively inhibit FGFR2 IIIb or FGFR2 IIIc, or both isoforms. The aim of this paper is to summarize the roles of FGFR2 and its isoforms in CRC and clarify whether they are potent therapeutic targets for CRC.

scholarly journals Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 69976-69990 ◽  
Author(s):  
Mohamed A. Ahmed ◽  
Edgar Selzer ◽  
Wolfgang Dörr ◽  
Gerd Jomrich ◽  
Felix Harpain ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Radiation Therapy ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Induced Resistance ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth
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