scholarly journals Hepatitis C virus clearance correlates with HLA-DR expression on proliferating CD8+ T cells in immune-primed chimpanzees

Hepatology ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 803-813 ◽  
Author(s):  
Iryna Zubkova ◽  
Hongying Duan ◽  
Frances Wells ◽  
Howard Mostowski ◽  
Esther Chang ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Virus Clearance ◽  
Hla Dr

scholarly journals Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

2003 ◽  
Vol 197 (12) ◽  
pp. 1645-1655 ◽  
Author(s):  
Naglaa H. Shoukry ◽  
Arash Grakoui ◽  
Michael Houghton ◽  
David Y. Chien ◽  
John Ghrayeb ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Memory T Cells ◽  
Protective Role ◽  
Cytolytic Activity ◽  
Memory Cd8 T Cells ◽  
Rapid Acquisition ◽  
Virus Clearance

Few hepatitis C virus (HCV) infections resolve spontaneously but those that do appear to afford protective immunity. Second infections are usually shorter in duration and are less likely to persist but mechanisms of virus control in immune individuals have not been identified. In this study we investigated whether memory helper and/or cytotoxic T lymphocytes provide protection in chimpanzees serially reinfected with the virus. Clearance of the first infection took 3–4 mo and coincided with the delayed onset of CD4+ and CD8+ T cell responses. High frequencies of memory T cells targeting multiple HCV proteins were stable over 7 yr of follow-up. Animals were infected for a second time to assess the protective role of memory T cells. In contrast to the prolonged course of the first infection, viremia was terminated within 14 d. Control of this second infection was kinetically linked to rapid acquisition of virus-specific cytolytic activity by liver resident CD8+ T cells and expansion of memory CD4+ and CD8+ T cells in blood. The importance of memory CD8+ T cells in control of HCV infection was confirmed by antibody-mediated depletion of this lymphocyte subset before a third infection. Virus replication was prolonged despite the presence of memory CD4+ T helper cells primed by the two prior infections and was not terminated until HCV-specific CD8+ T cells recovered in the liver. These experiments demonstrate an essential role for memory CD8+ T cells in long-term protection from chronic hepatitis C.

Detection of naïve hepatitis C virus-specific CD8+ T cells in chronically infected patients

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
J Schmidt ◽  
DA Price ◽  
C Neumann-Haefelin ◽  
HE Blum ◽  
R Thimme
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells

scholarly journals Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers

1999 ◽  
Vol 96 (10) ◽  
pp. 5692-5697 ◽  
Author(s):  
X.-S. He ◽  
B. Rehermann ◽  
F. X. Lopez-Labrador ◽  
J. Boisvert ◽  
R. Cheung ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Peripheral Blood ◽  
Mhc Tetramers

The use of class-I HLA tetramers for the detection of hepatitis C virus NS3-specific CD8+ T cells in patients with chronic infection

2004 ◽  
Vol 287 (1-2) ◽  
pp. 91-99 ◽  
Author(s):  
F.Xavier López-Labrador ◽  
Xiao-Song He ◽  
Marina Berenguer ◽  
Ramsey C. Cheung ◽  
Teresa L. Wright ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Chronic Infection ◽  
Class I

scholarly journals Apoptotic Epitope–Specific CD8+T Cells and Interferon Signaling Intersect in Chronic Hepatitis C Virus Infection

2015 ◽  
Vol 213 (4) ◽  
pp. 674-683 ◽  
Author(s):  
Helene Martini ◽  
Alessandra Citro ◽  
Carmela Martire ◽  
Gabriella D'Ettorre ◽  
Giancarlo Labbadia ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Cd8 T Cells ◽  
Interferon Signaling ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Sa1525 – Visne Analysis of Hepatitis C Virus-Specific Cd8 T Cells from Direct Acting Antiviral-Treated Chronic Hcv Patients and Hcv Resolvers

2019 ◽  
Vol 156 (6) ◽  
pp. S-1232
Author(s):  
Jihad Aljabban ◽  
Pierre Tonnerre ◽  
Dan Kvistad ◽  
Max Robidoux ◽  
Joelle Brown ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Direct Acting Antiviral ◽  
Chronic Hcv ◽  
Direct Acting

scholarly journals Cutting Edge: Identification of Hepatitis C Virus-Specific CD8+T Cells Restricted by Donor HLA Alleles following Liver Transplantation

2004 ◽  
Vol 173 (9) ◽  
pp. 5355-5359 ◽  
Author(s):  
Hugo R. Rosen ◽  
David J. Hinrichs ◽  
Rachel L. Leistikow ◽  
Glenda Callender ◽  
Anne M. Wertheimer ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Hla Alleles
Sign in / Sign up

Export Citation Format

Share Document