scholarly journals Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Hepatology ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 974-985 ◽  
Author(s):  
Chi-Kuan Chen ◽  
Ching-Yao Yang ◽  
Kuo-Tai Hua ◽  
Ming-Chih Ho ◽  
Gunnar Johansson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Vascular Invasion ◽  
Tyrosine Phosphatase ◽  
Receptor Activation ◽  
Protein Tyrosine Phosphatase 1B ◽  
Met Receptor ◽  
Protein Tyrosine

scholarly journals Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma

Hepatology ◽  
2016 ◽  
Vol 63 (5) ◽  
pp. 1528-1543 ◽  
Author(s):  
Wei-Tien Tai ◽  
Yao-Li Chen ◽  
Pei-Yi Chu ◽  
Li-Ju Chen ◽  
Man-Hsin Hung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine

scholarly journals Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase

2008 ◽  
Vol 283 (49) ◽  
pp. 34374-34383 ◽  
Author(s):  
Veena Sangwan ◽  
Grigorios N. Paliouras ◽  
Jasmine V. Abella ◽  
Nadia Dubé ◽  
Anie Monast ◽  
...  
Keyword(s):  
T Cell ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Met Receptor ◽  
Protein Tyrosine ◽  
Met Receptor Tyrosine Kinase

Inhibition of Protein Tyrosine Phosphatase 1B by Lutein Derivatives isolated from Mexican Oregano (Lippia graveolens)

2018 ◽  
Vol 17 (3) ◽  
pp. 134-139
Author(s):  
R.M. Perez-Gutierrez
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Tyrosine Phosphatase ◽  
Positive Control ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Ic50 Value ◽  
Ic50 Values

Methanol extract from Lippia graveolens (Mexican oregano) was studied in order to identify inhibitory bioactives for protein tyrosine phosphatase 1B (PTP1B). Known flavone as lutein (1), and another flavone glycoside such as lutein-7-o-glucoside (2), 6-hydroxy-lutein-7-ohexoside (3) and lutein-7-o-ramnoide (4) were isolated from methanol extract of aerial parts of the Lippia graveolens. All isolates were identified based on extensive spectroscopic data analysis, including UV, IR, NMR, MS and compared with spectroscopic data previously reported. These flavones were evaluated for PTP1B inhibitory activity. Among them, compounds 1 and 3 displayed potential inhibitory activity against PTP1B with IC50 values of 7.01 ± 1.25 μg/ml and 18.4 μg/ml, respectively. In addition, compound 2 and 4 showed moderate inhibitory activity with an IC50 value of 23.8 ± 6.21 and 67.8 ± 5.80 μg/ml respectively. Among the four compounds, luteolin was found to be the most potent PTP1B inhibitor compared to the positive control ursolic acid, with an IC50 value of 8.12 ± 1.06 μg/ml. These results indicate that flavonoids constituents contained in Lippia graveolens can be considered as a natural source for the treatment of type 2 diabetes.

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