scholarly journals RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma

Hepatology ◽  
2013 ◽  
Vol 59 (2) ◽  
pp. 518-530 ◽  
Author(s):  
Qing Deng ◽  
Kun-Yu Li ◽  
Hui Chen ◽  
Ji-Hong Dai ◽  
Yang-Yang Zhai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rna Interference ◽  
Therapeutic Target ◽  
Human Hepatocellular Carcinoma ◽  
Potential Therapeutic Target ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Cancer Testis

scholarly journals Regulation of TREM1-Mediated Inflammation in Hepatocellular Carcinoma Cells

Reports ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 17
Author(s):  
Vikrant Rai ◽  
Devendra K. Agrawal
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Chronic Inflammation ◽  
Therapeutic Target ◽  
Primary Liver Cancer ◽  
Migration And Invasion ◽  
Potential Therapeutic Target ◽  
Mediators Of Inflammation ◽  
Tnf Α ◽  
Hcc Cells

Hepatocellular carcinoma (HCC), accounting for more than 90% of cases of primary liver cancer, is the third most common cause of cancer-related death worldwide. Chronic inflammation precedes the development of cirrhosis and HCC. TREM (triggering receptor expressed on myeloid cell)-1 is an inflammatory marker and amplifier of inflammation that signals through PI3K and ERK1/2 to activate transcription factors, resulting in increased secretion of pro-inflammatory cytokines, causing chronic inflammation and predisposing the liver to carcinogenesis. Thus, targeting TREM-1 in HCC might be a potential therapeutic target. A low level of vitamin D has been associated with chronic inflammation and poor prognosis in HCC. Thus, we evaluated the effect of vitamin D on TREM-1 expression in the HCC cell line. Additionally, the effects of high mobility group box-1, lipopolysaccharide, and transcription factor PU.1 on the expression of TREM-1 in normal liver cells and HCC cells have been investigated in the presence and absence of vitamin D. The results showed increased expression of TREM-1 in HCC cells and with IL-6, TNF-α, LPS, and rHMGB-1 and decreased expression with calcitriol. Calcitriol also attenuated the effect of IL-6, TNF-α, LPS, and rHMGB-1 on TREM-1. Calcitriol treatment attenuated the proliferation, migration, and invasion of HCC cells. These results (in vitro) provide molecular and biochemical evidence that calcitriol significantly attenuates the expression of mediators of inflammation, and thus might be used therapeutically together with conventional treatment to delay the progression of HCC. Additionally, the negative regulation of TREM-1 by PU.1 suggests PU.1 as a potential therapeutic target.

scholarly journals Integrative bioinformatics analysis identifies ROBO1 as a potential therapeutic target modified by miR-218 in hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 61327-61337 ◽  
Author(s):  
Junqing Wang ◽  
Yunyun Zhou ◽  
Xiaochun Fei ◽  
Xunhua Chen ◽  
Rui Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Target ◽  
Bioinformatics Analysis ◽  
Potential Therapeutic Target

scholarly journals TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 24163-24177 ◽  
Author(s):  
Dong-Sheng Zhou ◽  
Hong-Bo Wang ◽  
Zhong-Guo Zhou ◽  
Yao-Jun Zhang ◽  
Qian Zhong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target
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