scholarly journals IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism

Hepatology ◽  
2013 ◽  
Vol 58 (4) ◽  
pp. 1436-1450 ◽  
Author(s):  
Massimiliano Sarra ◽  
Maria Laura Cupi ◽  
Roberta Bernardini ◽  
Giulia Ronchetti ◽  
Ivan Monteleone ◽  
...  
Keyword(s):  
Fulminant Hepatitis ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Dependent Mechanism

P.18.8 IL-25 PREVENTS AND CURES FULMINANT HEPATITIS THROUGH A MYELOID-DERIVED SUPPRESSOR CELL-DEPENDENT MECHANISM

2013 ◽  
Vol 45 ◽  
pp. S212
Author(s):  
M.L. Cupi ◽  
R. Bernardini ◽  
G. Ronchetti ◽  
I. Monteleone ◽  
E. Franzè ◽  
...  
Keyword(s):  
Fulminant Hepatitis ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Dependent Mechanism

scholarly journals RIP3 blockade prevents immune-mediated hepatitis through a myeloid-derived suppressor cell dependent mechanism

2022 ◽  
Vol 18 (1) ◽  
pp. 199-213
Author(s):  
Man Liu ◽  
Hongxia Zhang ◽  
Lu Zhang ◽  
Xin Liu ◽  
Simin Zhou ◽  
...  
Keyword(s):  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Immune Mediated ◽  
Dependent Mechanism

scholarly journals Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27690 ◽  
Author(s):  
Jeremy D. Waight ◽  
Qiang Hu ◽  
Austin Miller ◽  
Song Liu ◽  
Scott I. Abrams
Keyword(s):  
Suppressor Cell ◽  
Neoplastic Growth ◽  
Myeloid Derived Suppressor Cell ◽  
Dependent Mechanism

scholarly journals Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell–Dependent Mechanism

2014 ◽  
Vol 75 (3) ◽  
pp. 519-531 ◽  
Author(s):  
Siqi Chen ◽  
Long Wang ◽  
Jie Fan ◽  
Cong Ye ◽  
Donye Dominguez ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Suppressor Cell ◽  
Myeloid Derived Suppressor Cell ◽  
Dependent Mechanism

scholarly journals Targeting MDSC for Immune-Checkpoint Blockade in Cancer Immunotherapy: Current Progress and New Prospects

2021 ◽  
Vol 15 ◽  
pp. 117955492110355
Author(s):  
Tianhang Li ◽  
Tianyao Liu ◽  
Wenjie Zhu ◽  
Shangxun Xie ◽  
Zihan Zhao ◽  
...  
Keyword(s):  
Immune Checkpoint ◽  
Immune Escape ◽  
Suppressor Cell ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Great Promise ◽  
Therapy Process ◽  
Myeloid Derived Suppressor Cell ◽  
Anti Cancer ◽  
Immune Suppressor

Immune-checkpoint blockade (ICB) demonstrated inspiring effect and great promise in anti-cancer therapy. However, many obstacles, such as drug resistance and difficulty in patient selection, limited the efficacy of ICB therapy and awaited to be overcome. By timely identification and intervention of the key immune-suppressive promotors in the tumor microenvironment (TME), we may better understand the mechanisms of cancer immune-escape and use novel strategies to enhance the therapeutic effect of ICB. Myeloid-derived suppressor cell (MDSC) is recognized as a major immune suppressor in the TME. In this review, we summarized the roles MDSC played in the cancer context, focusing on its negative biologic functions in ICB therapy, discussed the strategies targeted on MDSC to optimize the diagnosis and therapy process of ICB and improve the efficacy of ICB therapy against malignancies.

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