scholarly journals In Vivohyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model

Hepatology ◽  
2013 ◽  
Vol 57 (2) ◽  
pp. 515-524 ◽  
Author(s):  
Philip Lee ◽  
Waifook Leong ◽  
Trish Tan ◽  
Miangkee Lim ◽  
Weiping Han ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mouse Model ◽  
Pyruvate Carboxylase ◽  
Resonance Spectroscopy ◽  
Resistant Mouse ◽  
Insulin Resistant

[P-002]: Proton magnetic resonance spectroscopy in Alzheimer's mouse model

2005 ◽  
Vol 1 ◽  
pp. S9-S9
Author(s):  
Malgorzata Marjanska ◽  
Geoffry L. Curran ◽  
Thomas M. Wengenack ◽  
Joseph F. Poduslo ◽  
Clifford R. Jack ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mouse Model ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

scholarly journals Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease

2012 ◽  
Vol 31 (s3) ◽  
pp. S87-S99 ◽  
Author(s):  
Vladimír Mlynárik ◽  
Matthias Cacquevel ◽  
Lili Sun-Reimer ◽  
Sharon Janssens ◽  
Cristina Cudalbu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mouse Model ◽  
Resonance Spectroscopy ◽  
Phosphorus Magnetic Resonance Spectroscopy ◽  
Model Of Alzheimer’S Disease

scholarly journals Magnetic resonance spectroscopy analysis of intramyocellular lipid composition in lipodystrophic patients and athletes

2018 ◽  
Author(s):  
David B Savage ◽  
Laura Watson ◽  
Katie Carr ◽  
Claire Adams ◽  
Soren Brage ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Tibialis Anterior ◽  
Saturation Index ◽  
Resonance Spectroscopy ◽  
Intramyocellular Lipid ◽  
Age And Gender ◽  
Insulin Resistant ◽  
And Gender

AbstractContextParadoxically, intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and to insulin-sensitive (athletes) states. The composition of this lipid store is unknown in these states.Design and MethodsWe used a recently validated and potentially widely applicable 1H magnetic resonance spectroscopy method to compare the compositional saturation index (CH2:CH3 ratio) and concentration independent of composition (CH3) of intramyocellular lipid in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic patients with that of age- and gender-matched athletes (n=14) and healthy controls (n = 41).Main OutcomeIMCL compositional saturation index (CH2:CH3 ratio).ResultsThe IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic patients compared with age- and gender-matched controls but not compared to athletes. IMCL CH2:CH3 was dependent on IMCL concentration in the controls and after adjusting the composition index for quantity (CH2:CH3adj) was able to distinguish patients from athletes. With groups pooled, this CH2:CH3adj marker had the strongest relation to insulin resistance (HOMA-IR) compared to other measures of lipid concentration and composition, especially in the soleus muscle. Contrary to the ‘athlete’s paradox’, IMCL in athletes was similar in tibialis anterior (p>0.05) and significantly lower in the soleus (p < 0.004) compared to both controls and patients.ConclusionsThe IMCL saturation index adjusted for quantity, which likely reflects accumulation of saturated IMCL, is more closely associated with insulin resistance than concentration alone.

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