scholarly journals Second infections independently increase mortality in hospitalized patients With cirrhosis: the north american consortium for the study of end-stage liver disease (NACSELD) experience

Hepatology ◽  
2012 ◽  
Vol 56 (6) ◽  
pp. 2328-2335 ◽  
Author(s):  
Jasmohan S. Bajaj ◽  
Jacqueline G. O'Leary ◽  
K. Rajender Reddy ◽  
Florence Wong ◽  
Jody C. Olson ◽  
...  
Keyword(s):  
Liver Disease ◽  
North American ◽  
Hospitalized Patients ◽  
End Stage Liver Disease ◽  
The North ◽  
End Stage

scholarly journals High risk of delisting or death in liver transplant candidates following infections: Results from the North American consortium for the study of end-stage liver disease

2015 ◽  
Vol 21 (7) ◽  
pp. 881-888 ◽  
Author(s):  
K. Rajender Reddy ◽  
Jacqueline G. O'Leary ◽  
Patrick S. Kamath ◽  
Michael B. Fallon ◽  
Scott W. Biggins ◽  
...  
Keyword(s):  
Liver Disease ◽  
High Risk ◽  
Liver Transplant ◽  
North American ◽  
End Stage Liver Disease ◽  
The North ◽  
Transplant Candidates ◽  
End Stage

Atrial fibrillation in hospitalized patients with end‐stage liver disease: temporal trends in prevalence and outcomes

2019 ◽  
Vol 40 (3) ◽  
pp. 674-684
Author(s):  
Hedong Han ◽  
Yingyi Qin ◽  
Yamei Yu ◽  
Xin Wei ◽  
Honglei Guo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Temporal Trends ◽  
Hospitalized Patients ◽  
End Stage Liver Disease ◽  
End Stage

scholarly journals Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Mari M. Kitahata ◽  
Daniel R. Drozd ◽  
Heidi M. Crane ◽  
Stephen E. Van Rompaey ◽  
Keri N. Althoff ◽  
...  
Keyword(s):  
Liver Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Predictive Value ◽  
Clinical Criteria ◽  
Clinical Endpoints ◽  
End Stage Liver Disease ◽  
The North ◽  
Stage Renal Disease ◽  
End Stage

The burden of HIV disease has shifted from traditional AIDS-defining illnesses to serious non-AIDS-defining comorbid conditions. Research aimed at improving HIV-related comorbid disease outcomes requires well-defined, verified clinical endpoints. We developed methods to ascertain and verify end-stage renal disease (ESRD) and end-stage liver disease (ESLD) and validated screening algorithms within the largest HIV cohort collaboration in North America (NA-ACCORD). Individuals who screened positive among all participants in twelve cohorts enrolled between January 1996 and December 2009 underwent medical record review to verify incident ESRD or ESLD using standardized protocols. We randomly sampled 6% of contributing cohorts to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ESLD and ESRD screening algorithms in a validation subcohort. Among 43,433 patients screened for ESRD, 822 screened positive of which 620 met clinical criteria for ESRD. The algorithm had 100% sensitivity, 99% specificity, 82% PPV, and 100% NPV for ESRD. Among 41,463 patients screened for ESLD, 2,024 screened positive of which 645 met diagnostic criteria for ESLD. The algorithm had 100% sensitivity, 95% specificity, 27% PPV, and 100% NPV for ESLD. Our methods proved robust for ascertainment of ESRD and ESLD in persons infected with HIV.

scholarly journals A219 EARLY PREDICTORS OF UNFAVORABLE OUTCOME IN NORTH AMERICAN INDIAN CHILDHOOD CIRRHOSIS

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 252-253
Author(s):  
L Khendek ◽  
F Alvarez ◽  
M Beaunoyer ◽  
E Drouin ◽  
M Lallier ◽  
...  
Keyword(s):  
Liver Disease ◽  
American Indian ◽  
North American ◽  
Bone Health ◽  
Unfavorable Outcome ◽  
Indian Childhood Cirrhosis ◽  
End Stage Liver Disease ◽  
Indian Childhood ◽  
North American Indian ◽  
End Stage

Abstract Background North American Indian Childhood Cirrhosis (NAIC) has only been described in the Cree-Ojibway First Nations of Northern Quebec. NAIC presents with transient neonatal jaundice and progresses to biliary cirrhosis often requiring liver transplantation (LT) in childhood. Only 30 patients have been described to date and risk factors associated with an earlier progression to LT have not yet been identified. Moreover, NAIC patients seem to experience more fractures than other cholestatic patients, but this has not been confirmed. Aims With this study, we aimed to identify predictors at 6 months from presentation that might suggest progression to end-stage liver disease as well as evaluate bone health in affected patients. Methods The records of all NAIC patients diagnosed between 2000–2020 were reviewed. Subjects were split into 2 groups based on whether they had undergone LT or not (No_LT) before age 18. Recorded complications included: hepatic encephalopathy (HE), variceal bleeding (VB), ascites, spontaneous bacterial peritonitis (SBP), bacteremia, and pulmonary shunts. Laboratory data (alanine aminotransferase, ALT; total bilirubin, TB) were collected at presentation and follow-up. Bone mineral density (BMD) of the lumbar spine (Z-scores) and number of fractures were compared between groups. NAIC patients were then compared to cohorts with other chronic cholestatic diseases such as biliary atresia (BA, n=24) and Alagille syndrome (AS, n=11). Results A total of 14 patients (M=9, F=5) were diagnosed with NAIC. Average age at presentation was 2.1 months (IQR 1–16.9 months), with 3 patients older than 18 months. Overall, 6 patients were transplanted (avg 8.6±1.7 years), one was listed for LT but died waiting, and 7 remained in a state of compensated cirrhosis. All complications were only observed in the LT group except for VB which also occurred in 2 patients of the No_LT group. Between presentation and 6 months, ALT and TB levels increased more in the LT vs No_LT group (p=ns). There was a greater variation of ALT/TB levels in the LT group (p=0.0047) even once the 3 patients with late referral were excluded (p=0.0381). No patient in the No_LT group had fractures, while 3 did in the LT group. BMD was lower in the LT group vs No_LT group (-2.2±1.2 vs. -1.1±1.3, p=ns). NAIC patients had lower BMD (-1.7±1.3) than those with AS (0.7±0.9, p=0.003) or BA (-0.9±1.4, p=ns) and had a higher prevalence of fractures (21.4% vs. 12.5% for BA and 18.2% for AS patients). Conclusions In patients with NAIC, variation of ALT/TB levels at 6 months from presentation may be used as an early predictor of unfavorable outcome and progression towards end-stage liver disease. Patients who evolved to LT had more complications, higher prevalence of fractures and lower BMD values. Compared to children with BA or AS, NAIC patients had poorer bone health. Funding Agencies None

553 DEMOGRAPHIC PREDICTORS OF SUCCESSFUL CARDIO-PULMONARY RESUSCITATION IN NATIONAL COHORT OF END-STAGE LIVER DISEASE HOSPITALIZED PATIENTS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1280
Author(s):  
Savan Kabaria ◽  
Lauren Pioppo ◽  
Debashis Reja ◽  
Augustine Tawadros ◽  
Peter Dellatore ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hospitalized Patients ◽  
End Stage Liver Disease ◽  
Demographic Predictors ◽  
Cardio Pulmonary Resuscitation ◽  
National Cohort ◽  
End Stage
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