Intestinal absorption, hepatic synthesis, and biliary secretion of cholesterol: Where are we for cholesterol gallstone formation?

Hepatology ◽  
2012 ◽  
Vol 55 (5) ◽  
pp. 1313-1316 ◽  
Author(s):  
Piero Portincasa ◽  
David Q.-H. Wang
Keyword(s):  
Intestinal Absorption ◽  
Cholesterol Gallstone ◽  
Gallstone Formation ◽  
Biliary Secretion ◽  
Hepatic Synthesis

Increased risk of cholesterol gallstone formation in subjects with apolipoprotein E4 genotype

1998 ◽  
Vol 10 (12) ◽  
pp. A8
Author(s):  
K. J. van Erpecum ◽  
P. Portincasa ◽  
E. R.M. Eckhardt ◽  
B. J.M. van de Heijning ◽  
A. K. Groen ◽  
...  
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Formation ◽  
Apolipoprotein E4 ◽  
Increased Risk

scholarly journals T-Cell Function Is Critical for Murine Cholesterol Gallstone Formation

2007 ◽  
Vol 133 (4) ◽  
pp. 1304-1315 ◽  
Author(s):  
Kirk J. Maurer ◽  
Varada P. Rao ◽  
Zhongming Ge ◽  
Arlin B. Rogers ◽  
Trisha J. Oura ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Cholesterol Gallstone ◽  
Gallstone Formation ◽  
T Cell Function

scholarly journals Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice

2000 ◽  
Vol 4 (1) ◽  
pp. 59-65 ◽  
Author(s):  
BEVERLY PAIGEN ◽  
NICHOLAS J. SCHORK ◽  
KAREN L. SVENSON ◽  
YIN-CHAI CHEAH ◽  
JIAN-LONG MU ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Congenic Strain ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Gallstone Formation ◽  
Quantitative Trait Loci Mapping ◽  
Cholesterol Gallstones ◽  
Lithogenic Diet ◽  
The Difference ◽  
Trait Locus

Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR × C57L) F1× AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at ∼20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK.L- Lith1s. Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L- Lith2s. Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.

scholarly journals The Role of Diet in the Pathogenesis of Cholesterol Gallstones

2019 ◽  
Vol 26 (19) ◽  
pp. 3620-3638 ◽  
Author(s):  
Agostino Di Ciaula ◽  
Gabriella Garruti ◽  
Gema Frühbeck ◽  
Maria De Angelis ◽  
Ornella de Bari ◽  
...  
Keyword(s):  
Vitamin C ◽  
Fast Food ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Gallstone Formation ◽  
Protective Role ◽  
Cholesterol Homeostasis ◽  
Major Health Problem ◽  
Cholesterol Gallstones ◽  
Beneficial Effects

: Cholesterol gallstone disease is a major health problem in Westernized countries and depends on a complex interplay between genetic factors, lifestyle and diet, acting on specific pathogenic mechanisms. Overweigh, obesity, dyslipidemia, insulin resistance and altered cholesterol homeostasis have been linked to increased gallstone occurrence, and several studies point to a number of specific nutrients as risk- or protective factors with respect to gallstone formation in humans. There is a rising interest in the identification of common and modifiable dietetic factors that put the patients at risk of gallstones or that are able to prevent gallstone formation and growth. In particular, dietary models characterized by increased energy intake with highly refined sugars and sweet foods, high fructose intake, low fiber contents, high fat, consumption of fast food and low vitamin C intake increase the risk of gallstone formation. On the other hand, high intake of monounsaturated fats and fiber, olive oil and fish (ω-3 fatty acids) consumption, vegetable protein intake, fruit, coffee, moderate alcohol consumption and vitamin C supplementation exert a protective role. : The effect of some confounding factors (e.g., physical activity) cannot be ruled out, but general recommendations about the multiple beneficial effects of diet on cholesterol gallstones must be kept in mind, in particular in groups at high risk of gallstone formation.

Increased risk of cholesterol gallstone formation in subjects with apolipoprotein E4 genotype: Its relation to bile composition and crystalization

1998 ◽  
Vol 114 ◽  
pp. A547
Author(s):  
K.J. van Erpecum ◽  
P. Portincasa ◽  
E.R.M. Eckhardt ◽  
B.J.M. van de Heijning ◽  
A.K. Groen ◽  
...  
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Formation ◽  
Bile Composition ◽  
Apolipoprotein E4 ◽  
Increased Risk

scholarly journals Cholesterol gallstone formation and prevention by chenodeoxycholic and ursodeoxycholic acids

1979 ◽  
Vol 77 (4) ◽  
pp. 634-641 ◽  
Author(s):  
B.J. Pearlman ◽  
G.G. Bonorris ◽  
M.J. Phillips ◽  
A. Chung ◽  
S. Vimadalal ◽  
...  
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Formation
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