scholarly journals Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response

Hepatology ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 20-29 ◽  
Author(s):  
Yasuhiro Asahina ◽  
Kaoru Tsuchiya ◽  
Masaru Muraoka ◽  
Keisuke Tanaka ◽  
Yuichiro Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Innate Immunity ◽  
Genetic Variation ◽  
Antiviral Response ◽  
Interleukin 28B

scholarly journals An alternative STAT signaling pathway acts in antiviral immunity in Caenorhabditis elegans

2017 ◽  
Author(s):  
Mélanie Tanguy ◽  
Louise Véron ◽  
Przemyslaw Stempor ◽  
Julie Ahringer ◽  
Peter Sarkies ◽  
...  
Keyword(s):  
Gene Expression ◽  
Innate Immunity ◽  
Antiviral Immunity ◽  
Antiviral Response ◽  
Evolutionary Trajectory ◽  
C Elegans ◽  
Regulatory Cascade ◽  
Innate Immune Signaling ◽  
Antiviral Innate Immunity ◽  
Reverse Genetic Screen

AbstractAcross metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of the JAK kinases to induce expression of antiviral effector genes. In the nematode C. elegans, which lacks the interferon system, the major antiviral response so far described is RNA interference but whether additional gene expression responses are employed is not known. Here we show that, despite the absence of both interferon and JAK, the C. elegans STAT homologue STA-1 orchestrates antiviral immunity. Intriguingly, mutants lacking STA-1 show increased resistance to antiviral infection. Using gene expression analysis and chromatin immunoprecipitation we show that, in contrast to the mammalian pathway, STA-1 acts as a transcriptional repressor. Thus STA-1 might act to suppress a constitutive antiviral response in the absence of infection. Using a reverse genetic screen we identify the SID-3 as a kinase upstream of STA-1 in the response to infection. Together, our work identifies a novel STAT regulatory cascade controlling its activity in antiviral resistance, illustrating the complex evolutionary trajectory displayed by innate immune signaling pathways across metazoan organisms.

scholarly journals Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk

Cancer ◽  
2013 ◽  
Vol 119 (9) ◽  
pp. 1761-1761 ◽  
Author(s):  
Robert P. Young ◽  
Raewyn J. Hopkins
Keyword(s):  
Lung Cancer ◽  
Innate Immunity ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Lung Cancer Risk

Impact of cinnamaldehyde on innate immunity and immune gene expression in Channa striatus against Aphanomyces invadans

2021 ◽  
Author(s):  
Ramasamy Harikrishnan ◽  
Gunapathy Devi ◽  
Chellam Balasundaram ◽  
Hien Van Doan ◽  
Sanchai Jaturasitha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Innate Immunity ◽  
Immune Gene ◽  
Channa Striatus ◽  
Immune Gene Expression

scholarly journals A Hybrid IRF9-STAT2 Protein Recapitulates Interferon-stimulated Gene Expression and Antiviral Response

2003 ◽  
Vol 278 (15) ◽  
pp. 13033-13038 ◽  
Author(s):  
Thomas A. Kraus ◽  
Joe F. Lau ◽  
Jean-Patrick Parisien ◽  
Curt M. Horvath
Keyword(s):  
Gene Expression ◽  
Antiviral Response
Sign in / Sign up

Export Citation Format

Share Document