scholarly journals Noninvasive methods for the assessment of liver fibrosis: A window open on the future?

Hepatology ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 1476-1477 ◽  
Author(s):  
Massimo Pinzani
Keyword(s):  
Liver Fibrosis ◽  
Noninvasive Methods ◽  
The Future

Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: A prospective study

2008 ◽  
Vol 32 (2) ◽  
pp. 180-187 ◽  
Author(s):  
X. Adhoute ◽  
J. Foucher ◽  
D. Laharie ◽  
E. Terrebonne ◽  
J. Vergniol ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Prospective Study ◽  
Noninvasive Methods ◽  
A Prospective Study

Noninvasive Tests in the Assessment of NASH and NAFLD Fibrosis: Now and Into the Future

2020 ◽  
Vol 40 (04) ◽  
pp. 331-338
Author(s):  
Leon A. Adams ◽  
Wah-Kheong Chan
Keyword(s):  
Fatty Liver Disease ◽  
Serum Markers ◽  
Response To Treatment ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver ◽  
Imaging Methods ◽  
The Future ◽  
Direct Measures ◽  
Noninvasive Tests

AbstractNoninvasive serum and imaging methods offer accessible, accurate, and safe assessment of fibrosis severity in nonalcoholic fatty liver disease. In contrast, current serum and imaging methods for the prediction of nonalcoholic steatohepatitis are not sufficiently accurate for routine clinical use. Serum fibrosis markers that incorporate direct measures of fibrogenesis (for example, hyaluronic acid) or fibrinolysis are generally more accurate than biomarkers not incorporating direct measures of fibrogenesis. Elastography methods are more accurate than serum markers for fibrosis assessment and particularly for the determination of cirrhosis, but have a significant failure and/or unreliability rate in obese individuals. To overcome this, combining serum and elastography methods in a sequential manner minimizes indeterminate results and maintains accuracy. The accuracy of current noninvasive methods for monitoring fibrosis response to treatment are limited; however, new tools derived from “omic” methodologies offer promise for the future.

F-25 Prospective validation of noninvasive methods to assess liver fibrosis in HCV patients after liver transplantation (LT)

2012 ◽  
Vol 44 ◽  
pp. S39-S40
Author(s):  
M. Gambato ◽  
A.C. Frigo ◽  
M. Senzolo ◽  
F.P. Russo ◽  
G. Germani ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Fibrosis ◽  
Noninvasive Methods

scholarly journals Diffusion-Weighted MRI for the Assessment of Liver Fibrosis: Principles and Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Stefano Palmucci ◽  
Giuseppina Cappello ◽  
Giancarlo Attinà ◽  
Giovanni Fuccio Sanzà ◽  
Pietro Valerio Foti ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Liver Fibrosis ◽  
Apparent Diffusion Coefficient ◽  
Sampling Errors ◽  
Noninvasive Methods ◽  
Gold Standard Method ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Fibrosis Regression ◽  
Technical Principles

The importance of an early identification of hepatic fibrosis has been emphasized, in order to start therapy and obtain fibrosis regression. Biopsy is the gold-standard method for the assessment of liver fibrosis in chronic liver diseases, but it is limited by complications, interobserver variability, and sampling errors. Several noninvasive methods have been recently introduced into clinical routine, in order to detect liver fibrosis early. One of the most diffuse approaches is represented by diffusion-weighted liver MRI. In this review, the main technical principles are briefly reported in order to explain the rationale for clinical applications. In addition, roles of apparent diffusion coefficient, intravoxel incoherent motion, and relative apparent diffusion coefficient are also reported, showing their advantages and limits.

scholarly journals Noninvasive diagnosis of liver fibrosis in the complex cardiac malformation survivors – a review of the literature

2020 ◽  
Author(s):  
Roxana-Cristina Mares ◽  
Cristina Oana Marginean
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Close Monitoring ◽  
Noninvasive Methods ◽  
Cardiac Malformations ◽  
Non Invasive ◽  
Electronic Database Search ◽  
Diagnostic Modalities ◽  
Congestive Liver ◽  
Evidence Based Guidelines

The aim of this review is to summarize the information on the pathogenesis and diagnosis of congestive liver disease sec-ondary to the Fontan and Glenn surgery for complex cardiac malformations, focusing on non-invasive diagnostic modalities. We performed an electronic database search (Pubmed, Web of Science) with the data range from 2001 to 2020. We selected the studies that addressed the pathogenesis of congestive liver disease secondary to cardiac malformations and articles regarding noninvasive methods of determining liver fibrosis in this group. We found that conventional imaging methods do not allow the detection of the initial stages of liver fibrosis. Elastography results are altered by congestion and cut-off values are not yet validated. More studies are required in order to provide evidence-based guidelines regarding the non-invasive diagnosis of hepatic fibrosis secondary to congenital heart disease. Patients with congenital cardiac malformations require close monitoring and early diagnosis of liver complications to allow prompt therapeutic intervention.

scholarly journals Validation and Refinement of Noninvasive Methods to Assess Hepatic Fibrosis: Magnetic Resonance Elastography Versus Enhanced Liver Fibrosis Index

2019 ◽  
Vol 65 (4) ◽  
pp. 1252-1257 ◽  
Author(s):  
Kenneth E. Sherman ◽  
Enass A. Abdel-Hameed ◽  
Richard L. Ehman ◽  
Susan D. Rouster ◽  
Adriana Campa ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Magnetic Resonance Elastography ◽  
Noninvasive Methods ◽  
Liver Fibrosis Index

scholarly journals Intracranial EEG in the 21st Century

2020 ◽  
Vol 20 (4) ◽  
pp. 180-188 ◽  
Author(s):  
Barbara C. Jobst ◽  
Fabrice Bartolomei ◽  
Beate Diehl ◽  
Birgit Frauscher ◽  
Philippe Kahane ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
21St Century ◽  
High Frequency ◽  
Low Frequency ◽  
Epileptogenic Zone ◽  
Noninvasive Methods ◽  
Intracranial Eeg ◽  
Advantages And Disadvantages ◽  
Gamma Range ◽  
The Future

Intracranial electroencephalography (iEEG) has been the mainstay of identifying the seizure onset zone (SOZ), a key diagnostic procedure in addition to neuroimaging when considering epilepsy surgery. In many patients, iEEG has been the basis for resective epilepsy surgery, to date still the most successful treatment for drug-resistant epilepsy. Intracranial EEG determines the location and resectability of the SOZ. Advances in recording and implantation of iEEG provide multiple options in the 21st century. This not only includes the choice between subdural electrodes (SDE) and stereoelectroencephalography (SEEG) but also includes the implantation and recordings from microelectrodes. Before iEEG implantation, especially in magnetic resonance imaging -negative epilepsy, a clear hypothesis for seizure generation and propagation should be based on noninvasive methods. Intracranial EEG implantation should be planned by a multidisciplinary team considering epileptic networks. Recordings from SDE and SEEG have both their advantages and disadvantages. Stereo-EEG seems to have a lower rate of complications that are clinically significant, but has limitations in spatial sampling of the cortical surface. Stereo-EEG can sample deeper areas of the brain including deep sulci and hard to reach areas such as the insula.  To determine the epileptogenic zone, interictal and ictal information should be taken into consideration. Interictal spiking, low frequency slowing, as well as high frequency oscillations may inform about the epileptogenic zone. Ictally, high frequency onsets in the beta/gamma range are usually associated with the SOZ, but specialized recordings with combined macro and microelectrodes may in the future educate us about onset in higher frequency bands. Stimulation of intracranial electrodes triggering habitual seizures can assist in identifying the SOZ. Advanced computational methods such as determining the epileptogenicity index and similar measures may enhance standard clinical interpretation. Improved techniques to record and interpret iEEG may in the future lead to a greater proportion of patients being seizure free after epilepsy surgery.

NONINVASIVE ASSESSMENT OF HEPATIC FIBROSIS

2014 ◽  
pp. 5-11
Author(s):  
Thi Khanh Tuong Tran ◽  
Trong Thang Hoang
Keyword(s):  
Clinical Practice ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Liver Stiffness ◽  
Treatment Decision ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Noninvasive Methods ◽  
Non Invasive ◽  
Noninvasive Assessment

Staging of hepatic fibrosis is crucial for prognosis, surveillance and treatment decision in patients with chronic liver diseases in clinical practice. Liver biopsy has still the gold standard for assessment of hepatic fibrosis, but it has some limitations. To overcome this, non-invasive methods were developed. The methods of noninvasive assessment of liver fibrosis were divided into two main groups: serum biomarkers and techniques measuring liver stiffness. Each method has its own advantages and limits. Some studies suggest that the effectiveness of noninvasive methods for assessing liver fibrosis may increase when they are combined. The aim of this article is to review and update the different non invasive methods for assessment of hepatic fibrosis, their advantages, disadvantages, diagnostic accuracy and their applications in clinical practice. Key words: hepatic fibrosis, liver stiffness, chronic liver disease

scholarly journals Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Flavia F. Fernandes ◽  
Hugo Perazzo ◽  
Luiz E. Andrade ◽  
Alessandra Dellavance ◽  
Carlos Terra ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Latent Class Analysis ◽  
Chronic Hepatitis C ◽  
Gold Standard ◽  
Latent Class ◽  
Noninvasive Methods ◽  
Without A Gold Standard

Aims.To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-to-platelet-ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard.Methods.Significant fibrosis was defined asTE≥7.1 kPa,APRI≥1.5,ELF≥9.37, or LB METAVIRF≥2. Cirrhosis was defined asTE≥12.5 kPa,APRI≥2.0,ELF≥10.31, or LB as METAVIRF=4.Results.117 patients with chronic hepatitis C were included. In the LCA, for significant fibrosis the sensitivities and specificities (95% CI) were 0.92 (0.86–0.98) and 0.79 (0.72–0.86) for TE; 0.47 (0.40–0.54) and 0.99 (0.95–1.00) for APRI; 0.81 (0.74–0.88) and 0.78 (0.71–0.85) for ELF; and 0.86 (0.68–1.00) and 0.91 (0.79–1.00) for LB. For cirrhosis, the sensitivities and specificities were 0.92 (0.76–1.00) and 0.94 (0.91–0.97) for TE; 0.57 (0.37–0.77) and 0.97 (0.93–1.00) for APRI; 0.94 (0.84–1.00) and 0.88 (0.82–0.94) for ELF; and 0.30 (0.12–0.48) and 1.00 for LB.Conclusion.LCA was useful to evaluate accuracy of methods for liver fibrosis staging. Sensitivities and specificities of noninvasive methods were increased in LCA compared to the use of LB as the gold standard.

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