scholarly journals The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury

Hepatology ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 931-939 ◽  
Author(s):  
Ayako Suzuki ◽  
Elizabeth M. Brunt ◽  
David E. Kleiner ◽  
Rosa Miquel ◽  
Thomas C. Smyrk ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

S1873 The use of Liver Biopsy Evaluation in Determination of Autoimmune Hepatitis vs. Drug-Induced Liver Injury

2010 ◽  
Vol 138 (5) ◽  
pp. S-807 ◽  
Author(s):  
Ayako Suzuki ◽  
Thomas C. Smyrk ◽  
Rosa Miquel ◽  
David E. Kleiner ◽  
Elizabeth M. Brunt ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals The clinical features of drug-induced liver injury observed through liver biopsy: focus on relevancy to autoimmune hepatitis

2012 ◽  
Vol 18 (2) ◽  
pp. 213 ◽  
Author(s):  
Hye Young Ju ◽  
Jae Young Jang ◽  
Soung Won Jeong ◽  
Sung Ae Woo ◽  
Min Gyu Kong ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Clinical Features ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Menotrophin Induced Autoimmune Hepatitis

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Shurouq H. Alqrinawi ◽  
Nuralhuda Akbar ◽  
Hind AlFaddag ◽  
Shahrazad Akbar ◽  
Lujayn Akbar ◽  
...  
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Plasma Cells ◽  
Caucasian Woman ◽  
Drug Induced ◽  
Over The Counter ◽  
Drug Induced Liver Injury ◽  
First Case ◽  
Igg Level ◽  
New Onset

Menotrophin is a protein-based hormonal therapy. It is used as a fertility medication that is given as injection either subcutaneously or intramuscularly. Menotrophin has not been previously reported to cause drug-induced liver injury. Drug-induced liver injury (DILI) is commonly seen nowadays with the expansion of the drug industry. It is associated with prescribed medications, over the counter drugs, herbal and dietary supplements. We report the first case of Menotrophin-induced autoimmune hepatitis in a 26-year-old Caucasian woman who was diagnosed with primary infertility due to failure to conceive after five years of marriage. She had received several cycles of Menotrophin, then developed new onset jaundice and fatigue associated with increase in transaminases. She had normal baseline liver function and enzymes prior to receiving treatment with Menotrophin. Evaluation showed no evidence of viral hepatitis, metabolic, alcoholic or vascular causes of liver injury. Autoimmune screening was positive for antinuclear antibody (ANA) with titer of 1 : 640 fine speckled, immunoglobulin G (IgG) level was 1900 mg/dl. Antimitochondrial antibodies (AMA) and antismooth muscle antibodies were negative. Liver biopsy showed features of chronic hepatitis with interface hepatitis and prominence of plasma cells, which best reflects autoimmune hepatitis. Her liver enzymes and bilirubin completely normalized after discontinuation of further Menotrophin therapy and starting treatment with prednisolone and Azathioprine.

scholarly journals Drug induced liver injury and its relationship to autoimmune hepatitis

2011 ◽  
Vol 55 (4) ◽  
pp. 747-749 ◽  
Author(s):  
Christina Weiler-Normann ◽  
Christoph Schramm
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Seven cases of autoimmune hepatitis that developed after drug-induced liver injury

Hepatology ◽  
2011 ◽  
Vol 54 (5) ◽  
pp. 1892-1893 ◽  
Author(s):  
Kazushi Sugimoto ◽  
Takeshi Ito ◽  
Norihiko Yamamoto ◽  
Katsuya Shiraki
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Grace Guzman ◽  
Eric R. Kallwitz ◽  
Christina Wojewoda ◽  
Rohini Chennuri ◽  
Jamie Berkes ◽  
...  
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Plasma Cells ◽  
Hepatic Necrosis ◽  
Serum Markers ◽  
Black Cohosh ◽  
Herbal Supplement ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms. Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis. Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease. Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury. In addition, the biopsies showed characteristics of autoimmune-like liver injury with an interface hepatitis dominated by plasma cells. Although serum markers for autoimmune hepatitis were not particularly elevated, both patients responded to corticosteroids, supporting an immune-mediated component to the liver injury. Liver injury following the use of black cohosh should be included in the list of differential diagnoses for chronic hepatitis with features mimicking autoimmune hepatitis.

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