scholarly journals Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

Hepatology ◽  
2011 ◽  
Vol 53 (6) ◽  
pp. 1917-1931 ◽  
Author(s):  
Timea Csak ◽  
Angela Dolganiuc ◽  
Karen Kodys ◽  
Bharath Nath ◽  
Jan Petrasek ◽  
...  
Keyword(s):  
Liver Injury ◽  
Antiviral Response ◽  
Antiviral Signaling ◽  
Signaling Protein ◽  
Mitochondrial Antiviral Signaling ◽  
Mitochondrial Antiviral Signaling Protein

The Q41R mutation in HCV-protease enhances the reactivity towards MAVS by suppressing non-reactive pathways

2021 ◽  
Author(s):  
Chen Zheng ◽  
Markus Schneider ◽  
Antoine Marion ◽  
Iris Antes
Keyword(s):  
Significant Enhancement ◽  
New Mutation ◽  
Antiviral Signaling ◽  
Signaling Protein ◽  
Hcv Protease ◽  
Mitochondrial Antiviral Signaling ◽  
Experimental Findings ◽  
Mitochondrial Antiviral Signaling Protein

Recent experimental findings pointed out a new mutation in HCV protease, Q41R, responsible for a significant enhancement of the enzyme’s reactivity towards the mitochondrial antiviral-signaling protein (MAVS). The Q41R mutation...

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