scholarly journals Patatin-Like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

Hepatology ◽  
2011 ◽  
Vol 53 (3) ◽  
pp. 791-799 ◽  
Author(s):  
Luca Valenti ◽  
MariaGrazia Rumi ◽  
Enrico Galmozzi ◽  
Alessio Aghemo ◽  
Benedetta Del Menico ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage

scholarly journals Histopathological and immunocytochemical changes in the liver of patients with chronic hepatitis C

2004 ◽  
Vol 61 (1) ◽  
pp. 29-34
Author(s):  
Maja Jovanovic ◽  
Ljiljana Konstantinovic ◽  
Vuka Katic ◽  
Slavisa Ciric ◽  
Velimir Kostic ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Liver Parenchyma ◽  
Hepatic Tissue ◽  
Biopsy Specimens ◽  
Viral Hepatitis C ◽  
Viremia Level ◽  
Chronic Active Viral Hepatitis

Background. The presence of lymphocytes within the liver parenchyma is related to immunologically mediated liver damage in chronic hepatitis C. The aim of the study was to make histological, histochemical, and immunocytochemical assessment of liver biopsy specimens in patients with chronic hepatitis C virus (HCV) infection. Methods. Biopsy specimens of 20 patients with chronic HCV disease were analyzed, using standard staining procedures to verify histologic liver lesions, as well as immunoenzymatic staining with monoclonal antibodies to detect CD4+ T-lymphocytes, B-lymphocytes, and macrophages. Results. Micromorphologic characteristics of chronic active viral hepatitis C were present in all the patients, differing, hower, by the level of their activity. Dominant changes were found within the portal space, consisting of mononuclear lympho-plasmocytic infiltration and macrophages. Immunocytochemical investigation of mononuclear and macrophageal infiltration showed the correlation between micromorphological findings and the degree of the activity. Conclusion. The presence of lymphocytic and macrophageal infiltration within the hepatic tissue directly correlated with the intensity of the liver damage. Analysis of the population of cellular infiltrate in the liver together with the monitoring of viremia level and the level of hepatocyte necrosis, could be useful tools for elucidation of the pathogenesis of chronic hepatitis C.

scholarly journals Fibrosis in Chronic Hepatitis C: Correlation between Immunohistochemically-Assessed Virus Load with Steatosis and Cellular Iron Content

2016 ◽  
Vol 4 (4) ◽  
pp. 578-584
Author(s):  
Maha Akl ◽  
Ali EL Hindawi ◽  
Maha Mosaad ◽  
Ahmed Montasser ◽  
Ahmed El Ray ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Cellular Iron ◽  
Iron Load ◽  
Cirrhotic Group ◽  
Sirius Red

AIM: We aimed study impact of hepatocytic viral load, steatosis, and iron load on fibrosis in chronic hepatitis C and role of VEGF and VEGFR overexpression in cirrhotic cases in evolving HCC.MATERIAL AND METHODS: Total of 120 cases were included from TBRI and Beaujon Hospital as chronic hepatitis C (CHC), post-hepatitis C cirrhosis, and HCC. Cases of CHC were stained for Sirius red, Prussian blue and immunohistochemically (IHC) for HCV-NS3/NS4. HCC were stained IHC for VEGF and by FISH.RESULTS: Stage of fibrosis was significantly correlated with inflammation in CHC (P < 0.01). Noticed iron load did not correlate with fibrosis. Steatosis was associated with higher inflammation and fibrosis. The cellular viral load did not correlate with inflammation, steatosis or fibrosis. VEGF by IHC was significantly higher in cases of HCC when compared to cirrhotic group (P < 0.001). Amplification of VEGFR2 was confirmed in 40% of cases of HCC. Scoring of VEGF by IHC was the good indicator  of VEGFR2 amplification by FISH (P < 0.005).CONCLUSION: Grade of inflammation is the factor affecting fibrosis in CHC. The degree of liver damage is not related to cellular viral load or iron load. Steatosis is associated with higher inflammation and fibrosis. VEGF by IHC is correlated with overexpression of VEGFR2 by FISH.

scholarly journals Influence of cytokine and cytokine receptor gene polymorphisms on the degree of liver damage in patients with chronic hepatitis C

Meta Gene ◽  
2016 ◽  
Vol 9 ◽  
pp. 90-96 ◽  
Author(s):  
Sara Tatiana Moreira ◽  
Giovanni Faria Silva ◽  
Camila Fernanda Verdichio de Moraes ◽  
Rejane Maria Tomasini Grotto ◽  
Maria Inês de Moura Campos Pardini ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Cytokine Receptor ◽  
Receptor Gene Polymorphisms

Chronic hepatitis C, ibuprofen, and liver damage

2002 ◽  
Vol 97 (7) ◽  
pp. 1854-1855 ◽  
Author(s):  
Raul J. Andrade ◽  
Maria Isabel Lucena ◽  
Miren Garcia-Cortes ◽  
Elena Garcia-Ruiz ◽  
Eva Fernandez-Bonilla ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage

Plasma alpha-glutathione S-transferase assessed as a marker of liver damage in patients with chronic hepatitis C

1995 ◽  
Vol 41 (12) ◽  
pp. 1716-1719 ◽  
Author(s):  
M Vaubourdolle ◽  
O Chazouillères ◽  
I Briaud ◽  
C Legendre ◽  
L Serfaty ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Normal Values ◽  
Glutathione S Transferase ◽  
Blood Samples ◽  
Gamma Glutamyltransferase ◽  
Hepatocellular Damage ◽  
Biochemical Assessment

Abstract alpha-Glutathione S-transferase (alpha-GST; EC 2.5.1.18) has been advocated as a better marker of hepatocellular damage than the transaminases in toxic and autoimmune hepatitis. We have assessed the potential interest of plasma alpha-GST determination in 94 anti-hepatitis C virus-positive patients with histologically proven chronic hepatitis C (34 women, 60 men, ages 40.0 +/- 11.9 years). Blood samples were assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase, alkaline phosphatase, and alpha-GST on the same day a liver biopsy was performed. alpha-GST concentrations were significantly above reference values in 64% of patients (compared with 58% for AST, 68% for ALT), and this increase was seen in 52% of patients with normal values for transaminases and a Knodell score &gt; 3. Furthermore, there was a significant correlation between alpha-GST and lobular necrosis score (r = 0.31; P &lt; 0.01). Our findings suggest that association of plasma alpha-GST with ALT may improve the biochemical assessment of liver damage in patients with chronic hepatitis C.

Co-infection with several HCV genotypes enhances liver damage in patients with chronic hepatitis C

1997 ◽  
Vol 35 (2) ◽  
pp. 202-203
Author(s):  
V. Soriano ◽  
R. Bravo ◽  
J. García-Samaniego ◽  
J. Castilla ◽  
A. Castro ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Hcv Genotypes
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