Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis

Hepatology ◽  
2011 ◽  
Vol 53 (3) ◽  
pp. 854-864 ◽  
Author(s):  
Christine Gauglhofer ◽  
Sandra Sagmeister ◽  
Waltraud Schrottmaier ◽  
Carina Fischer ◽  
Chantal Rodgarkia-Dara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Cell Survival ◽  
Fibroblast Growth Factor ◽  
Human Hepatocellular Carcinoma ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 8

scholarly journals Cubilin, a High Affinity Receptor for Fibroblast Growth Factor 8, Is Required for Cell Survival in the Developing Vertebrate Head

2013 ◽  
Vol 288 (23) ◽  
pp. 16655-16670 ◽  
Author(s):  
Olivier Cases ◽  
Aitana Perea-Gomez ◽  
Diego P. Aguiar ◽  
Anders Nykjaer ◽  
Sabine Amsellem ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Survival ◽  
Fibroblast Growth Factor ◽  
Cell Uptake ◽  
Fibroblast Growth ◽  
Fgf Signaling ◽  
Mouse Development ◽  
Fibroblast Growth Factor 8 ◽  
High Affinity ◽  
Head Surface

Cubilin (Cubn) is a multiligand endocytic receptor critical for the intestinal absorption of vitamin B12 and renal protein reabsorption. During mouse development, Cubn is expressed in both embryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality most likely due to the impairment of the function of extra-embryonic Cubn. Here, we focus on the developmental role of Cubn expressed in the embryonic head. We report that Cubn is a novel, interspecies-conserved Fgf receptor. Epiblast-specific inactivation of Cubn in the mouse embryo as well as Cubn silencing in the anterior head of frog or the cephalic neural crest of chick embryos show that Cubn is required during early somite stages to convey survival signals in the developing vertebrate head. Surface plasmon resonance analysis reveals that fibroblast growth factor 8 (Fgf8), a key mediator of cell survival, migration, proliferation, and patterning in the developing head, is a high affinity ligand for Cubn. Cell uptake studies show that binding to Cubn is necessary for the phosphorylation of the Fgf signaling mediators MAPK and Smad1. Although Cubn may not form stable ternary complexes with Fgf receptors (FgfRs), it acts together with and/or is necessary for optimal FgfR activity. We propose that plasma membrane binding of Fgf8, and most likely of the Fgf8 family members Fgf17 and Fgf18, to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity.

Sinusoidal Capillarization of Human Hepatocellular Carcinoma: Possible Promotion by Fibroblast Growth Factor

Oncology ◽  
1993 ◽  
Vol 50 (4) ◽  
pp. 270-274 ◽  
Author(s):  
Yoshiharu Motoo ◽  
Norio Sawabu ◽  
Yasushi Yamaguchi ◽  
Tadashi Terada ◽  
Yasuni Nakanuma
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Hepatocellular Carcinoma ◽  
Fibroblast Growth
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