scholarly journals Liver mass with central calcification

Hepatology ◽  
2011 ◽  
Vol 53 (4) ◽  
pp. 1397-1398 ◽  
Author(s):  
Andreas Lanitis ◽  
Christian Toso
Author(s):  
A. Cuadrado ◽  
J. Crespo ◽  
J. Cabriada ◽  
F. Pons-Romero

2010 ◽  
Vol 90 (4) ◽  
pp. 699-718 ◽  
Author(s):  
Cherif Boutros ◽  
Steven C. Katz ◽  
N. Joseph Espat
Keyword(s):  

1994 ◽  
Vol 14 (04) ◽  
pp. 395-403 ◽  
Author(s):  
Susan McCormick ◽  
Maria Sjogren ◽  
Zachary Goodman

2021 ◽  
Vol 28 (3) ◽  
pp. 611
Author(s):  
Seyit Uyar ◽  
Ahmet Alparslan ◽  
Demet Aydin ◽  
Betul Erdogan ◽  
Gamze Kavas ◽  
...  

Author(s):  
Rajalakshmi Govalan ◽  
Maha Guindi ◽  
Ju Dong Yang
Keyword(s):  

2021 ◽  
Vol 18 ◽  
Author(s):  
Pedro Pires Goulart Guimarães ◽  
Celso Tarso Rodrigues Viana ◽  
Luciana Pereira ◽  
Savio Morato Lacerda Gontijo ◽  
Paula Peixoto Campos ◽  
...  

Background: Colorectal cancer (CRC) is the third most common cancer in the world. 5-Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemic toxicity, such as hepatotoxicity and gastrointesti-nal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platforms to overcome resistance and therapeutic delivery of active molecules. Here, we develop 5-FU loaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in the colorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effect of 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in a colon cancer xen-ograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatment with 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, which could act in conjunction to enhance antitumor effi-cacy. In addition, 5-FU-SUL-PLGA NPs significantly reduced liver mass and lung mass, which are the most common metastasis sites of CRC, and decreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy to enhance 5-FU efficacy against CRC.


1990 ◽  
Vol 83 (1) ◽  
pp. 51-53 ◽  
Author(s):  
DAVID A. MAGED ◽  
HERBERT J. KEATING
Keyword(s):  

2002 ◽  
Vol 10 (2) ◽  
pp. 56-61 ◽  
Author(s):  
Mp Hillmer ◽  
S Salama ◽  
Sm Macleod

Keloid scars are benign fibroproliferative growths that respond poorly to treatment. This study sought to determine the efficacy of three different glucocorticoids (triamcinolone, methylprednisolone and dexamethasone) in altering human keloid scar tissue implanted in athymic mice. Keloid tissue obtained from three patients (one man and two women) who sought cosmetic removal of their scars was implanted into athymic mice for a duration of 15 or 30 days. The keloid tissue was examined histopathologically and evaluated by a dermatopathologist who was blinded to sample identity and who was using predetermined qualitative scoring criteria. The appearance of central calcification, granulation tissue, foreign body granulomatous reaction and acute inflammatory reaction complicated the comparison of the keloid tissue samples. However, on the basis of observations reported in the present paper, it appears that triamcinolone should remain the treatment of choice for keloid scars. The athymic mouse model that is used for studying keloid scars is the best available approach to in vivo studies; however, limitations identified in this study confound the interpretation of experimental data. Ideally, promising and novel therapies should be investigated clinically.


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